Deficiency of Mesencephalic Astrocyte–Derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice

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Colitogenic Environment Suppresses Notch/Mechanistic Target of Rapamycin–Mediated Epithelial Proliferation to Promote Goblet Cell Differentiation in the Colon

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Rora Regulates Hematopoietic Stem Cell Phenotypes and Progression of Chronic Myelogenous Leukemia

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Tissue Inhibitor of Metalloproteinase 2 Promotes Wound Healing by Suppressing Matrix Metalloproteinases and Inflammatory Cytokines in Corneal Epithelial Cells Tissue inhibitors of metalloproteinases (TIMPs) modulate extracellular matrix remodeling for maintaining homeostasis and promoting cell migration and proliferation. Pathologic conditions can alter TIM...

#LegacyContent: Tissue Inhibitor of Metalloproteinase-2 Promotes Wound Healing by Suppressing Matrix Metalloproteinases and Inflammatory Cytokines in Corneal Epithelial Cells. Authors from @harvardmed.bsky.social

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Check out this new study from Mass General Brigham researchers in @ajpathology.bsky.social!

ADH1C Down-Regulation Is a Key Hypoxia Response in Colon Epithelium

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Keratocyte Depletion by Genetic Manipulation Re-creates Corneal Ectasia in a Mouse Model

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#ArticleinPress: Dermal Microvascular Responses of Human Induced Pluripotent Stem Cell–Derived Skin Organoids to Inflammation and Injury

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Peroxisome Proliferator-Activated Receptor α Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy

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Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells

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#ArticleinPress: Pseudogene-Derived Long Noncoding RNAs GSTM3P1/Gstm2-ps1 Exacerbate Sepsis-Associated Acute Kidney Injury by Suppressing Their Parent Gene Translation

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Characterization and Role of Glucagon-Like Peptide 1 Receptor in the Lacrimal Gland This study aimed to investigate the expression of glucagon-like peptide 1 receptor (GLP-1R) in the lacrimal gland and explore the effects of topical application of GLP-1R agonist on lacrimal gland fun...

#LegacyContent: Characterization and Role of Glucagon-Like Peptide 1 Receptor in the Lacrimal Gland: Novel Insights into Diabetic Dry Eye Pathogenesis.

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#ArticleinPress: Leukocytic Dopamine D2 Receptors as Biomarkers for Brain Dopamine Levels in Parkinson Disease. From @asipath.bsky.social member Scott Steffensen.

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#ArticleinPress: Redefining Pathobiology with Spatial Multi-Omics at the Intersection of Biology, Computation, and Histopathological Assessment

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The April issue of @ajpathology.bsky.social is now live!

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On the cover: Deterioration of colonic crypts in dextran sulfate sodium treated mice.

#ArticleinPress: Applications of Spatial Transcriptomics in Ischemic Stroke Research. Authors from @czechacademy.bsky.social

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#ArticleinPress: Retinal Hypoxia as an Early-Detection Imaging Biomarker for Diabetic Retinopathy.

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Machine Learning–Based Pathomics Model Predicts ANGPT2 Expression and Prognosis in Hepatocellular Carcinoma

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P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers Mitochondrial maladaptation and dysfunction contribute to the progression of metabolic dysfunction-associated steatohepatitis (MASH). Induction of Shc is implicated in progressive MASH during aging an...

#LegacyContent: P46Shc Inhibits Mitochondrial ACAA2 Thiolase, Exacerbating Mitochondrial Injury and Inflammation in Aging Livers. From @asipath.bsky.social member author Natalie Török and colleagues @ucdavishealth.bsky.social.

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Genetic Loss of HIF-Prolyl-Hydroxylase 1, but Not Pharmacological Inhibition, Mitigates Hepatic Fibrosis Liver fibrosis is characterized by excessive deposition of extracellular matrix due to chronic inflammation of the liver. Hepatic stellate cells (HSCs) become activated and produce increased amounts o...

#LegacyContent: Genetic Loss of HIF-Prolyl-Hydroxylase 1, but Not Pharmacological Inhibition, Mitigates Hepatic Fibrosis.

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Emerging Mechanistic Roles of STING Signaling in Kidney Diseases

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Throughout 2025 we published a series of #AJPCentennial editorials showcasing seminal articles that appeared in AJP over the last century, as well as some forward-looking pieces predicting the future of key areas in pathobiology. A digital compendium is online here: https://loom.ly/BKOyYJU

Mechanistic Insights into Glucocorticoid-Induced Ocular Hypertension Using Differences in Mouse Strain Responsiveness.

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Systemic Disease Progression and Neurodegeneration in the Gbe1ys/ys Mouse Model of Glycogen Storage Disease Type IV. Authors from @dukehealth.bsky.social.

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#ArticleinPress: Organotypic Retinal Explant Culture as a Model for Neuroretinal Degenerative Disease and Future Applications.

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#ArticleinPress: Single-Cell Triomics Analysis of Tumor Cells Infiltrating Patient-Derived Breast Cancer Scaffolds. Authors from @missionbio.bsky.social

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DNA Methyltransferase 3A–Dependent Suppression of Hypoxia-Inducible Factor-1α Alleviates Myopia by Reducing Scleral Ferroptosis and Fibroblast Extracellular Matrix Remodeling

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#ArticleinPress: Deciphering the Cellular and Metabolic Landscape of Lymph Node Metastasis in Breast Cancer Using Single-Cell and Spatial Multi-Omics

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#ArticleinPress: Deficiency of Mesencephalic Astrocyte–Derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice

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