Throughout 2025 we published a series of #AJPCentennial editorials showcasing seminal articles that appeared in AJP over the last century, as well as some forward-looking pieces predicting the future of key areas in pathobiology. A digital compendium is online here: https://loom.ly/BKOyYJU

#AJPCentennial

A Seminal Work That Defined the Pathology of Frontotemporal Dementias and the Concept of TDP-43 Proteinopathies

Full text: ajp.amjpathol.org/article/S0002-9440(25)00...

#AJPCentennial

@ajpathology.bsky.social and the @asipath.bsky.social: Forging the Next Century of Insights into Mechanisms of Disease

Full text: ajp.amjpathol.org/article/S0002-9440(25)00...

#AJPCentennial

Navigating the Road to Progress in Neurodegeneration. From @asipath.bsky.social member Dr. Christi Kolarcik and Yomna Badawi.

Free to read: ajp.amjpathol.org/article/S0002-9440(25)00...

Read this special #AJPCentennial Guest Editorial from #ASIPmember and ASIP Past-President, Dr. Stephen Galli from @stanfordmedicine.bsky.social! Last year, Dr. Galli received the ASIP Gold Headed Cane #Award

#AJPCentennial Guest Editorial: Discovery and Mechanistic Insights into Vascular Permeability Factor/Vascular Endothelial Growth Factor through the Work of Harold F. Dvorak and Ann M. Dvorak.

Full text: ajp.amjpathol.org/article/S0002-9440(25)00...

The American Journal of Pathology’s Contribution to Advancing the Understanding of the Pathogenesis of Atherosclerosis From its debut in 1925, The American Journal of Pathology (AJP) has consistently published original experimental studies and periodic state-of-the-art review articles written by leading investigators ...

Read the latest #AJPCentennial Editorial from @asipath.bsky.social member and AJP Editorial Board member Avrum Gotlieb from @uoft.bsky.social.

@ajpathology.bsky.social’s Contribution to Advancing the Understanding of the Pathogenesis of #Atherosclerosis

ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

1. Apoptosis, oncosis, and necrosis: An overview of cell death.

Published January 1995. Cited 3,131 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

2. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

Published May 1995. Cited 3,043 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

3. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

Published July 1969. Cited 1,813 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry Tissue sections from aggressive human intraocular (uveal) and metastatic cutaneous melanomas generally lack evidence of significant necrosis and contain patterned networks of interconnected loops of e...

#AJPCentennial #Top100

4. Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry

Published September 1999. Cited 1,812 times.

Full text: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top10

5. Apoptosis. The role of the endonuclease.

Published March 1990. Cited 1,805 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

The Myofibroblast The crucial role played by the myofibroblast in wound healing and pathological organ remodeling is well established; the general mechanisms of extracellular matrix synthesis and of tension production ...

#AJPCentennial #Top100

6. The Myofibroblast: One Function, Multiple Origins

Published June 2007. Cited 1,785 times.

Full text: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

7. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma.

Published August 1993. Cited 1,648 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

8. Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal.

Published May 1998. Cited 1,536 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

9. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

Published April 1998. Cited 1,532 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

10. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa.

Published March/April 1951. Cited 1,493 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness Leakiness of blood vessels in tumors may contribute to disease progression and is key to certain forms of cancer therapy, but the structural basis of the leakiness is unclear. We sought to determine w...

#AJPCentennial #Top100

11. Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

Published April 2000. Cited 1,434 times.

Full text: ajp.amjpathol.org/article/S000...

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease We have characterized amyloid β peptide (Aβ. concentration, Aβ deposition, paired helical filament formation, cerebrovascular amyloid angiopathy, apolipoprotein E (ApoE) allotype, and synaptophysin co...

#AJPCentennial #Top100

12. Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease.

Published September 1999. Cited 1,428 times.

Full text: ajp.amjpathol.org/article/S000...

Ovarian Cancer Development and Metastasis The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only superficially inv...

#AJPCentennial #Top100

13. Ovarian Cancer Development and Metastasis.

Published September 2010. Cited 1,309 times.

Full text: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

14. The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.

Published January 1975. Cited 1,279 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

15. Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns

Published September 1947. Cited 1,279 times.

Full text: pubmed.ncbi.nlm.nih.gov/19970955/

#AJPCentennial: Blowing Dust Off the Archives: Seminal Eponymous Contributions from Women Pathologists in
@ajpathology.bsky.social. From @asipath.bsky.social member and Senior Associate Editor Dr. Richard Mitchell.

Read for free: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

16. Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis.

Published January 2010. Cited 1,225 times.

Full text: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

18. The Blood Supply of Neoplasms in the Liver.

Published October 1954. Cited 1,182 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial at #Pathobiology2025

#AJPCentennial #Top100

19. The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages.

Published August 2000. Cited 1,181 times.

Full text: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

20. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis.

Published May 1989. Cited 1,177 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...

#AJPCentennial #Top100

21. Genetic Pathways to Primary and Secondary #Glioblastoma

Published May 2007. Cited 1,159 times.

Full text: ajp.amjpathol.org/article/S000...

#AJPCentennial #Top100

22. Cerebral ischemia. II. The no-reflow phenomenon.

Published February 1968. Cited 1,159 times.

Full text: pmc.ncbi.nlm.nih.gov/articles/PMC...