Interesting paper on the genetics of familial hypercholesterolaemia using WGS of 77,260 samples.
jmg.bmj.com/content/63/5...
I find the large number of variants in LDLR particularly interesting for further investigations into the structural factors of LDLR - APOB interactions.
Come and join me for a GenomeWeb webinar supported by Seer on
"Unbiased Plasma Proteomics Expands GWAS Insights"
Wednesday, March 11, 2026
12:00 PM Eastern Daylight Time
Register here:
event.on24.com/wcc/r/521498...
More details:
www.genomeweb.com/events
Using @somalogic.bsky.social affinity #proteomics data from three cohorts and #pQTL association strength as a readout we identify protein signatures reflecting latent variation in aptamer-based affinity proteomics.
Learn how HSP90 can act as a proxy for cell-lysis.
pubs.acs.org/doi/full/10....
Very interesting approach… how about extending this to data that also has ion mobility data?
Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified #JProteomeRes pubs.acs.org/doi/10.1021/...
Our paper is now available in the print edition of Proteomics:
"Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort"
dx.doi.org/10.1002/pmic...
A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...
Here a tutorial on how to easily 3D-print proteins and other macro-molecules:
makerworld.com/en/models/96...
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome.
By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome
www.nature.com/articles/s41...
Read our latest paper just published in Nature Genetics :
A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform
www.nature.com/articles/s41...
Honestly - these days the most interesting part is often the exchange with the reviewers - great idea to make these public: our paper has 67 pages, they can be found here: static-content.springer.com/esm/art%3A10...
I agree, the Somalogic VTN pQTL is certainly such a case.
Suspense !
Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...
Genomics of drug target prioritization for complex diseases - a Nature Reviews Genetics review:
www.nature.com/articles/s41...
Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes:
www.niddk.nih.gov/about-niddk/...
Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming.
Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15...
citing our #Qatar study with @metabolon.bsky.social data:
www.cell.com/cell-genomic...
How did you mathematically generate these?
“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM.
news.weill.cornell.edu/news/2025/10...
🔬Inside the Core Lab: Driving Discovery in #Proteomics
Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs.
Featured in the lead-up to #QPC2025 — where innovation meets collaboration.
This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff.
www.niddk.nih.gov/about-niddk/...
A pretty comprehensive comparison of most actual #proteomics platforms:
Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery
www.nature.com/articles/s42...
October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon.
www.lipidmaps.org/updates/lipi...
Great initiative… Unfortunately I can already see all kinds of IRB and MTA paperwork around sharing and shipping these samples around. Have seen too much of this lately. Feels like the central aim of doing research these days is being compliant. But maybe I am overly pessimistic.
"A standardized framework for circulating
blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects
www.nature.com/articles/s41...
I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level:
Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging
elifesciences.org/articles/96892
Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer.
But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.
(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS
