Our proposal for managing combination therapy while awaiting for susceptibility in Pseudomonas infections.

Find out more: journals.plos.org/plosone/arti... #AMSsky #IDsky #PsWatch

Combined antipseudomonal therapy does not improve outcomes and may increase toxicity.
Its main role is ensuring appropriate empirical therapy in severe infections, with no proven benefit once susceptibility is known.

📖 A systematic review: www.tandfonline.com/doi/full/10.... #AMSsky #IDsky #PsWatch

This post hoc analysis of the subgroup of patients with P. aeruginosa BSI recruited for the BALANCE RCT showed no differences in 90d mortality between patients treated for 7 vs 14d.

However, sample size and wide CIs preclude definite conclusions.

academic.oup.com/cid/advance-... #IDsky #AMSsky

El 18 de Marzo celebramos en Sevilla la IX Jornada de TB celebrando el día mundial de la TB. La inscripción es gratuita. Será presencial y on line simultáneamente. Os animamos a participar
#Tuberculosis #TBSky

Stay tuned
TAPER V2
Vanco taper Vs Fidaxomicin
Vancomycin Taper to Prevent Recurrent Clostridioides Difficile (TAPER-V2)
Study Details | NCT07328971 | Vancomycin Taper to Prevent Recurrent Clostridioides Difficile | #Idsky
clinicaltrials.gov/study/NCT07328…

Initial Vancomycin Taper for the Prevention of Recurrent C difficile Infection This randomized clinical trial tested whether a 4-week pulse and taper vancomycin regimen was superior to a 2-week pulse regimen for preventing recurrence among patients with a first episode or first ...

🔥Just published 🔥
TAPER-V RCT
In this RCT of 256, a 4-week vancomycin pulse and taper regimen *had a probability of 74% to be superior to a standard 2-week pulse regimen in patients a first episode or first recurrence of CDI
Vanco for 10d is obsolete! #IDSky #EMIMCC
jamanetwork.com/journals/jam...

Promotional Toolkit ESCMID Global (formerly ECCMID): an annual congress bringing together experts and specialists in Clinical Microbiology and Infectious Diseases.

With ESCMID Global quickly approaching!
To help you spread the word and get involved, check out ESCMID Global 2026 Promotional Toolkit
The official hashtag for the congress this year is #ESCMIDGlobal2026 on all social media channels. #IDSky
www.escmid.org/congress-eve...

Panel A: The weekly Gravitrap Aedes aegypti index (GAI), which measures the abundance of adult A. aegypti mosquitoes, in the intervention and control clusters before and during the release of wolbachia-infected male mosquitoes. Panel B: A spatial visualization of the intervention (red) and control (teal) clusters.

In this report from Singapore, the release of wolbachia-infected, irradiated male 𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes resulted in a reduction in the vector population and in the risk of dengue infection. Full report: nej.md/4atd2iN

#MedSky #IDSky

An illustrated diagram of the immunopathophysiology of VITT.

VITT is caused by a somatic hypermutation of an anti–adenovirus pVII antibody that generates more avid binding of platelet factor 4 than of adenovirus pVII, its original target, which results in platelet activation. Full study results: nej.md/3MBnaOx

#MedSky #Hematology

Advantages with HD. Check out this week’s KASIC pearl to learn about Hemodialysis-only Antibiotic Dosing kymdro.org/kasic/?p=8784

#IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs

Non pay walled link: authors.elsevier.com/a/1mCdH3AjoX...

Clarity Initiative Clinical Literature Appraisal and Research education in InfecTious diseases

A group of ID clinical researchers passionate about clinical research and evidence appraisal has just launched the CLARITY initiative (clarityinitiative.org), which aims to improve the generation and interpretation of evidence in ID and Microbiology.

Global and regional knowledge of antibiotic use and resistance among the general public: a systematic review and meta-analysis Antibiotic resistance threatens effective infection treatment and medical procedures. Global initiatives, such as World AMR Awareness Week, aim to improve public understanding and promote rational ant...

Although I'm not surprised that there is a huge disparity in the knowledge that antibiotics don't work against viruses globally, what is disappointing to see is there are still so many Americans who believe they do.
#IDSky #AMSSky
www.clinicalmicrobiologyandinfection.org/article/S119...

En infección urinaria, menos es más 👌🏻

Nuestro hilo sobre diagnóstico y tratamiento de la infección urinaria.

☝🏻 Bacteriuria asintomática

#EAAD #WAAW #AMSsky #MedSky #UTIsky
(🧵1/2)
bsky.app/profile/hosp...

👆🏻 #AMSsky

💡Applications for the 2026-2028 AMS Certificate Programme & EUCIC Certificate Programme are open! These training programmes are designed to strengthen your expertise in antimicrobial stewardship & IPC.

Learn more:
AMS: https://ow.ly/kYz550Xu6iW
EUCIC: https://ow.ly/zlsl50Xu6iU

#IDSky #clinmicro

#WinterIsComing 🥶

Un hilo con nuestras recomendaciones para acertar con tus tratamientos de consulta para las infecciones respiratorias.

☝🏻 Neumonías y EPOC reagudizado

#EAAD #WAAW #AMSsky #MedSky #PharmSky
(🧵1/4)
bsky.app/profile/hosp...

¿Trabajas en consulta?
¡Te necesitamos!

El uso prudente de los antibióticos es responsabilidad de todos. Durante toda esta semana, no te pierdas nuestros vídeos para hacer un uso prudente de los antibióticos.
💪🏻 ¡La lucha contra las resistencias empieza en tu consulta!
#EAAD #WAAW #AMSsky

¿Trabajas en consulta?
¡Te necesitamos!

Durante toda esta semana, no te pierdas nuestra serie de vídeos prácticos para hacer un uso prudente de los antibióticos en tus pacientes ambulatorios

👊🏻 La lucha contra las resistencias, empieza en tu consulta
#EAAD #WAAW #AMSsky #MedSky #PharmSky #SomosHUVR

¡Ya tenemos todo listo para el Día Europeo para el Uso Prudente de los Antibióticos!

Mantente atento a las redes de @hospitaluvrocio.bsky.social y @guiaprioam.bsky.social durante la semana que viene.
Tenemos un mensaje para ti… 😉

#EAAD #WAAW #AMSsky #SomosHUVR

DoxyPEP in MSM (n=362) led to 35.5% high-level tetracycline resistance vs. 12.5% in no-PEP (p=0.043). Cefixime susceptibility decreased (32.3% vs. 10.0%, p=0.033). AMR monitoring is essential.

#idsky

It’s SO #AMSsky… 😂😂😂

Dr Tamma mentions the ongoing GOAT trial (PI Tamma & Cosgrove)
This will be a most needed and important study. clinicaltrials.gov/study/NCT060...
#IDweek2025 #IDsky

New from IDSA, thanks to Dr William Werbel, resp virus vax in immunocompromised population:

- vax 2 weeks before or 3-6 months after immunocompromise expected
- expect blunted response if given within that window
- defer during acute rejection, illness
- adjust for viral circulation
#IDSky #IDWeek

🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...

Fantastic - this will be an impactful study on treatment duration of blood stream Pseudomonas infection.

Our centre already mostly does 7 days (and my prediction is that this will be non-inferior) but it's RCT like these that will shift dial across the board with persuasive evidence.

#IDSky #AMR

The rationale of the RCT was testing the current standard (7d) in the specific setting of Pseudomonas BSIs.

The DURATIONS design is a relevant contribution, but it adds complexity and I wonder if a multi-arm (5?) approach is convenient when testing durations in such a narrow timeframe.

There was a session at ESCMID 2025 on macrolides for CAP and this paper was heavily featured (lead investigator was panelist). Patient population in this trial was much “sicker” than in other studies. I was convinced of their role and benefit, but not for every hospitalized pt (icu only perhaps)

Totally agree. Definitely not for any CAP.

I was also shocked by the mean age (>80y) and Charlson. Probably this was a major driver for the high mortality, beyond the severity of the infection itself — mean CURB65 was 2-3, the setting for recruitment were Internal Medicine wards instead of ICUs…

I have the same concern!
In this RCT, 25% of patients received steroids in both arms.
The subgroup analysis showed benefits independently (and apparently superior) to the use of steroids, but this relevant question was not primarily addressed by the trial
pdf.sciencedirectassets.com/271247/1-s2....