This is from The Tonight Show with Johnny Carson aired on May 20th, 1977.

Carl Sagan says something very important, a strong message that didn't lose any validity since then.

We’ll know open science has truly gone mainstream once OSF @cos.io beats the Old Spaghetti Factory in the search results.

This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.

The Continuing Crisis, Part IX: Inside the NIH Now

What it's like inside the NIH under current conditions: not good. Terrible uncertainty and low morale, and an inability to order even basic materials because of trouble with the purchasing department:

✨Symposium session reveal✨ Featuring @albertantolin.bsky.social and @karmencj.bsky.social, this session highlights initiatives enabling communities to come together to solve some of the biggest challenges in drug discovery. Register here: conscience.ca/symposium2025

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @uhntoronto.bsky.social, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery.

event.fourwaves.com/aircheckwork...

Revised and Extended: What's Happening Inside the NIH and NSF

I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War.

Same link, new title and some updates.

Host metabolism balances microbial regulation of bile acid signalling - Nature A family of host-derived bile acid–methylcysteamine conjugates functions as FXR antagonists, forming part of a microbiota-dependent metabolic network that regulates FXR-dependent physiology.

More than 25 years after FXR agonist GW4604 was described by now @thesgc.bsky.social scientist Tim Willson, it is still being used in cutting edge papers. High quality #ChemicalProbes are expensive to discover, but they’re the gift that keeps on giving.

www.nature.com/articles/s41...

What's Happening Inside the NIH and NSF

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.

www.science.org/content/blog...

Scientists are flocking to Bluesky because of "fewer Nazis" According to a poll by Nature, most scientists have left X for Bluesky. The environment simply has less obnoxious people in it.

They said it, we didn’t. 👀

boingboing.net/2025/01/28/s...

While we gear up to welcome both Polaris and ASAP to our Symposium in April, they have been cooking up something special.

They're releasing an intermediate leaderboard for the antiviral challenge on the 31st. So you (looking at #CACHEChallenge participants!) have a few days to get in a prediction!

📣 We heard your feedback! We’ll be putting all results submitted by Jan 31st on an intermediate leaderboard so you can see how you rank across other participants in the antiviral challenge.

Ready to put your predictions to the test?
📨 Submit your results today: polarishub.io/competitions

Are you working to advance #OpenScience, #AI -assisted drug design, or innovative approaches to #DrugDiscovery? Submit an abstract by March 7 for the opportunity to present a 3-minute flash talk at the Conscience Symposium on Open Drug Discovery on April 7-8, 2025, in Montreal!

Interested in building the future of open source ligand- and structure-based ML models for ADMET prediction?

The ARPA-H funded OMSF (@omsf.bsky.social) OpenADMET project is hiring multiple positions to build ML models of ADMET properties and drive informative data collection!

openadmet.org/jobs/

The characters of Daisy, Mrs. Reed, and Sam (in that order) from the show Black Doves. Daisy and Sam have guns, Mrs. Reed is talking on a phone.

I'm feeling pretty confident I'll be OK.

he's here @johnwilbanks.indieweb.social.ap.brid.gy (sorry John, your handle is just too long to fit in my post!)

Enjoyed this accessible talk by Head of Data at
@asterainstitute.bsky.social and @conscience-network.bsky.social board member John Wilbanks

It's the type of quality, down to earth advice and insight that only comes from decades of careful thought and really caring.

www.youtube.com/watch?v=4Xnl...

MAINFRAME membership offers:

- Access to high-quality training datasets
- Participation in benchmarking challenges with experimental validation
- Collaborative research opportunities

Join a community committed to open science: aircheck.ai/mainframe

Early registration is now open for the Conscience Symposium on Open Drug Discovery in Montreal on April 7-8! To ensure accessibility for all, we're offering significantly reduced registration fees for students and Early Bird discounts until Jan 31 - don't miss out! conscience.ca/event/consci...

CC Open Science: 2024 Year in Review - Creative Commons Science by Steve Rotman is licensed under CC BY-NC-ND 2.0 Access to science is a fundamental human right, and yet, much of that public good is inaccessible because of paywalls and limited in its reuse...

You didn't think we forgot about science did you? 🧬🧪 Our 2024 year in review reflections conclude with the Open Science program at CC.

Read more about the work of Open Science and what's to come in 2025: loom.ly/LOfb8A8

Waking up in the morning isn't so hard when you get to work on this mission with these people.

Drug development for all: How we believe Open Science can help develop treatments for those left behind - Conscience Health is core to our quality of life, yet millions worldwide lack treatments to diseases that threaten their lives or quality of life. For example, an estimated 400 million people worldwide live with...

Millions worldwide lack treatments for diseases that threaten their lives or quality of life. We believe #OpenScience is key to tackling these challenges and that we can transform #DrugDevelopment by fostering collaboration, sharing data, and prioritizing accessibility. conscience.ca/news/drug-de...

Want to learn more about what we're up to at @conscience-network.bsky.social and why we do what we do? Check out our latest blog post, written by @richardgold.bsky.social (and edited by me)! I couldn't be more proud to contribute to such a great mission. #OpenScience #DrugDevelopment

🥇 Inside the Best Paper from @neuripsconf.bsky.social FM4Science Workshop. Phil Fradkin of @valenceai.bsky.social presents MolPhenix - foundation model that predicts the effect of any given molecule & concentration pair on phenotypic cell assays & cell morphology. www.youtube.com/shorts/hpD4X...

Thank you to @neuripsconf.bsky.social for a lovely conference.

You didn't have "taking off on a seaplane in a windstorm" in the agenda but I recommend it for next year.

Better than 5 cups of coffee.

Finished off my time at @neuripsconf.bsky.social with another stroll round some posters.

I'm not sure when we'll be simulating biology with high fidelity but it was very cool to be in the room with some of the people making that future.

Till next year.

AI-dios

Special delivery from @neuripsconf.bsky.social! We just released our latest certified dataset, RxRx3-core, which includes labeled images of 735 genetic knockouts & 1,674 small-molecule perturbations. The related benchmark evaluates the zero-shot prediction of compound-gene activity. #NeurIPS
👇

🛡️ New certified dataset and benchmark from
@recursionpharma.bsky.social!

Did you know that high-dimensional data like cell images (i.e. phenomics) can help us understand the relationship between compounds and genes? 🧵

Dataset: polarishub.io/datasets/rec...
Benchmark: polarishub.io/benchmarks/r...

It is time for my favorite annual tradition: getting lightly tipsy, heading to the bookstore, pointing out 4-5 books I want to my partner, and then letting them pick one in secret for our xmas eve book exchange

The Old Testament? I think you mean The Great Begatsby