First *complete* view of the mouse hippocampus with in-vivo 2p imaging + ex-vivo MERSCOPE spatial transcriptomics!

* 🔊 sound on

Amazing collaboration led @jason_hc_yong
at @attila_losonczy's lab.

Preprint: biorxiv.org/content/10.648
98/2026.04.07.716935v1

Interactive website: shorturl.at/nCaAn

Two-photon calcium imaging at 24,000 lines/s, with the resonant axis spanning 4x what other systems can do. Inertia-free. Diffraction-limited. No tradeoffs. Che-Hang Yu developed a 4x angle multiplier for laser scanning. His paper is out today: opg.optica.org/optica/fullt... 1/n #fluorescenceFriday

Duration between rewards controls the rate of behavioral and dopaminergic learning - Nature Neuroscience Cue–reward learning rate scales proportionally with the time between rewards. Consequently, learning over a fixed duration is independent of the number of trials. This challenges trial-based dopamine ...

Very excited to post our paper led by @daburke.bsky.social www.nature.com/articles/s41... where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

I had a special & lovely visit to my alma mater NYCU to give a talk on my PhD work this week. Huge thanks to Dr. Tsai-Wen Chen and Dr. Bei-Jung Lin for hosting me! So excited to see some super cool voltage imaging rig and data 🤩😍⚡ Can't wait to see more sys neuro work from Taiwan!! 🧠

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻?
"High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions."
Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones.
NB: study in the mouse
#neuroskyence
doi.org/10.1038/s415...

Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

⚠️ New paper alert and what a way to end 2025! 🎉
Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience.

Sleeping dragons 🦎 and functional ultrasound!
Read the full paper here: rdcu.be/eWJHb 1/8

Posters printed (5x), talks made (2x), symposia chairing ironed out (2x), preprint posted (1x), whole lab on board (7x): 𝐁𝐢𝐥𝐛𝐚𝐨, 𝐡𝐞𝐫𝐞 𝐰𝐞 𝐜𝐨𝐦𝐞! #ECRO2025
🇪🇸🧠👃
ecro2025.com

@chloeg-neuro.bsky.social @harinw.bsky.social @connordoyle.bsky.social @ailiemcwhinnie.bsky.social @neurosana.bsky.social

Feeding-induced olfactory cortex suppression reduces satiation Binge feeding commonly leads to overeating. Experiencing flavor during food consumption contributes to satiation. Still, the interactions between flav…

🧠🔄 #NeuroThursday

Loops paper! 💡
@hunglo.bsky.social, Friedrich Johenning & team show that during binge feeding, OT GABA neurons silence piriform cortex → flavors fade, fullness lags and eating continues!

Who knew smell circuits could fuel overeating? 🐭🧋

🔗 www.sciencedirect.com/science/arti...

Thanks for sharing our work ☺️😁🧋

Feeding-induced olfactory cortex suppression reduces satiation Lo et al. show that binge feeding suppresses piriform (olfactory) cortex activity, reducing the brain’s representation of food flavor. This suppression is driven by the olfactory tubercle and promotes...

New in Neuron: “Feeding-induced olfactory cortex suppression reduces satiation” @CharitéBerlin researchers. This study reveals how the sense of smell controls meal ending & binge eating behavior. Read more: tinyurl.com/227dw782 #Neuroscience #Satiation #BingeEating @hunglo.bsky.social & colleagues

It was a great colab! Thanks so much for your contributions!

Thanks for the highlights! 🙂

🚨 Preprint alert! 🚨
Can mice estimate the distance to an odour source?
New work led by Cristina Marin and colleagues, jointly supervised by @andreas-t-schaefer.bsky.social at the @crick.ac.uk and myself.

Spoiler alert: Yes, they can!

Read the paper here: bit.ly/43A9tF9
Short 🧵 below

Thank you Jonas, and yes finally 🫠🫠🫠

Thank you!

Thank you soooo much Elisa!!! 😁☺️I hope ppl in the lab enjoy the🧋hahaha

Thanks for kind words Luke! 😄

Finally, some personal updates, since this year I have started my postdoc with @lukesjulson.bsky.social at Albert Einstein College of Medicine in New York, studying prefrontal dynamics in addiction models. Hopefully, soon I'll have something cool to show you all!

Of course, I want to thank all authors that I haven't mentioned yet, thank you all so much!!
Matthew Larkum Benjamin Judkewitz Anke Schoenherr Laura Moreno Velásquez Lukas Faiss Amit Kumar Malinda Tantirigama Aileen Hakus Benjamin Rost Katharina Stumpenhorst Marion Rivalan York Winter!

Special thanks to Walter Cañedo Riedel, Kelsch lab, and @russoel.bsky.social lab for their contribution, where they analyzed the functional connectivity between OT and aPC and showed the recruitment of OT –| aPC circuit, providing a crucial link between these 2 brain regions.

In this version, we identified the missing link in the last version, a circuit mechanism of how the olfactory cortex (aPC) is suppressed during binge feeding. It turns out to be the GABAergic neurons in the olfactory tubercle (OT)! OT neurons project to aPC and are activated during binge feeding!

Thanks again to all the authors, especially my PhD supervisors Friedrich Johenning and Dietmar Schmitz. Thanks to all 3 reviewers, it was a relief to read the reviewers’ comments were all positive and supporting publication!

Paper link:
authors.elsevier.com/sd/article/S...

I'm more than psyched to share that my PhD paper is now out in Neuron! It's also my first paper as both first author and corresponding author, which means even more to me!

Thank my partner Chi-Chieh for her contribution to the most adorable ever graphic abstract 🥰

Great work from @facuumm.bsky.social and @ggirardeau.bsky.social ! Interesting that the cell assemblies activity is so sparse!

Dorso-ventral hippocampus neural assemblies reactivate during sleep following an aversive experience The integration of spatial and emotional components into episodic memory relies on coordinated interactions between hippocampal circuits and emotion-processing regions. While the dorsal hippocampus (d...

Hello folks!
New update on our bioXriv preprint!
With my amazing supervisor @ggirardeau.bsky.social , and the super team @belalima-paiva.bsky.social @azulsilva.bsky.social & Ele

www.biorxiv.org/content/10.1...

🧵1 of 4

A Neuropixels Opto probe with 3 blue emitters and 3 red emitters lighting up in succession, with corresponding neural activity in different layers of the cortex.

Neuropixels and Optogenetics are delighted to announce the birth of

Neuropixels Opto

Combining high-resolution electrophysiology and optogenetics

Today in bioRxiv

960 sites, 28 emitters, 2 colors

By Lakunina, @karolinazsocha.bsky.social, Ladd, et al

www.biorxiv.org/content/10.1...

(1/2)

🌟 Exciting News!🌟
I am thrilled to announce that the interdisciplinary symposium Scent and Imagination will take place on the 4th June 2025 in Cambridge (UK)! 🎉

Join us as we dive deep into the complex relationship between olfactory heritage and imagination 🌸💡

Congrats!! Beautiful work!

Perceptual constancy for an odor is acquired through changes in primary sensory neurons Learning-induced changes in primary sensory neurons support concentration-invariant perception of an odor.

We have a fresh new paper!
The PhD project of the talented Mark Conway.

A learning-induced change in the sensitivity of olfactory receptor neurons enables consistent perception of an odor. #olfaction #neuroscience

www.science.org/doi/10.1126/...