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Posts by Gavin Sherlock

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⏰ Only 2 DAYS left for early registration! Join us at #Yeast26 (June 13-17, Pacific Grove, CA) for cutting-edge research in #genetics, #genomics, #disease, #regulation, #systemsBiology, #cellBiology, #lifeCycle, #syntheticBiology, & more. Register by April 16 to save! 🧬 genetics-gsa.org/yeast-2026/

1 week ago 8 7 1 0
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We are recruiting 1-2 postdoctoral fellows to investigate the specificity of human anti-influenza virus antibodies, and to determine how these antibodies impact global antigenic drift of influenza viruses.

Join our lab at Penn in Philly. Reach out if you are interested in applying! Please repost!

1 week ago 17 20 0 1
A doctor costume, honestly, not Jesus…

A doctor costume, honestly, not Jesus…

1 week ago 4510 756 73 61
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New OpenFold3 preview out! (OF3p2)

It closes the gap to AlphaFold3 for most modalities.

Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

1 month ago 245 91 1 2
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Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes - The EMBO Journal As the tree of life becomes increasingly accessible to molecular investigations, describing mechanisms underlying evolutionary convergence and constraint will be crucial to understanding diversificati...

So pleased to share that this project identifying convergent evolution of aerobic fermentation in a poorly characterized genus of yeasts (Saturnispora) is now out in @embojournal.org

@hittingerlab.bsky.social @rokaslab.bsky.social @glbioenergy.bsky.social

link.springer.com/article/10.1...

1 week ago 21 9 1 0

New preprint with Bonny Brewer and Raghu's lab. Ku mutant genomes just go bonkers during chemostat evolution, but in very interesting ways! Telomeric amplicons of SUL1 and Y' in yeast are generated by microhomology-mediated break induced replication occurring in cis www.biorxiv.org/content/10.6...

1 week ago 6 5 0 0
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I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

Jack Szostak "All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."

1 week ago 401 139 5 9

It looks like there will be an open postdoc position in my lab soon. I'll be looking for someone with substantial wet-lab experience in microbiology / microbial ecology / evolution / physiology. If everything goes well, an ad will be coming. But if you know someone, ask them to reach out already.

1 week ago 29 30 0 0
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Life Science Research Professional 1 in School of Medicine, Stanford, California, United States Stanford University is seeking a Life Science Research Professional 1 to study the mechanisms of aging and rejuvenation, particularly in a variety of....

Interested in aging and rejuvenation?

We have a new Research Assistant position to understand aging at the cellular level!!

Come join our team!!! 😎

careersearch.stanford.edu/jobs/life-sc...

1 week ago 23 14 1 0

You can be opposed to the Iranian regime AND the reckless bombing of school kids.

You can support the troops AND be opposed to sending them into senseless wars.

You are not an antisemite if you decry the Israeli regime’s genocidal rampage.

Don’t let morons impose their idiotic view of the world.

2 weeks ago 5526 1458 128 57
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Trump has been in power for 2% of our nation's history but is responsible for 25% of our debt.

It's almost like he's bad at business.

2 weeks ago 4194 1125 119 42

But there’s still no god of course

2 weeks ago 0 0 0 0
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SGD Help - Gene Registry SGD Help: Gene Registry The SGD Gene Registry is the system used by the S. cerevisiae community and SGD to reserve standard names for newly characterized genes. The Gene Naming Guidelines describe how...

🧬 Characterized an unnamed #yeast #gene?
1. Name with 3 letters + number (ex. XYZ1) to reflect function.
2. Reserve your unique name at SGD while preparing manuscript www.yeastgenome.org/reserved_nam...
3. Include both ORF & gene names in your publication! 📝
Help: sites.google.com/view/yeastge...

2 weeks ago 5 6 1 0

I saw him at a travel convention in January - just a seriously lovely guy and thoughtful, concerned citizen, who literally is putting his money where his mouth is.

2 weeks ago 2 1 0 0

The fuckers to the left of me who voted for Jill Stein rather than Kamala, must surely pat themselves on the back on a daily basis at how they’ve fucked over this country.

2 weeks ago 0 0 0 0

periodic and timely reminder that "Marisa Tomei" is an anagram for "It's a me Mario"

2 weeks ago 250 51 1 3
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2 weeks ago 43 32 2 1
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Genotype-fitness mapping of adaptive mutants reveals shifting low-dimensional structure across divergent environments Predicting the effect of a genetic mutation on fitness is a major challenge in evolutionary biology. This study uses fitness effects of a large collection of adaptive yeast mutants in multiple lab env...

Really excited that this major work from my PhD is finally published in @plosbiology.org ! In it, we were trying to tackle a fundamental question in evolution - how do genetic mutations map onto evolutionary fitness? (1/n)
journals.plos.org/plosbiology/...

3 weeks ago 77 39 2 1
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#gasprices

3 weeks ago 12 2 1 0

I'm hiring! I have 2 open positions:

🔬 Postdoc
🧪 Research associate

We study how animal multicellularity evolved by exploring the molecular logic of cell adhesion using cell biology, 'omics, and tool-building in non-model organisms.

Come join us!

Details and application links 👇

Please repost

3 weeks ago 67 68 2 1
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No earth scientists, no astronomers, no one with expertise in biotechnology or medicine, no climate scientists, no materials scientists, no field biologists, no ocean scientists, no atmospheric scientists, no biochemists, no developmental biologists, no evolutionary biologists.

3 weeks ago 80 40 5 0

Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social

Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback.

rdcu.be/famFj

3 weeks ago 98 56 4 1

850 Tomahawk missiles could be $3,060,000,000... That is 3 billion sixty million US dollars.

That is 1224 5 year biomedical research grants. Literally, over 6 millennia of biomedical research.

3 weeks ago 373 174 11 7
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Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids A large set of intraspecific yeast hybrids was constructed using two strategies that yielded series of hybrids with variable ploidy. Phenotyping of the hybrids was carried out in high-stress media to....

In our recent study, we created over 1000 intraspecific yeast hybrids by crossing genetically diverse strains and tested how well they grow under harsh industrial conditions such as high ethanol, salt, and organic acids.

enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

3 weeks ago 12 7 1 0

Hmm - all but 4 papers have disappeared from my myNCBI bibliography, which makes creating a Biosketch through the SciENV platform somewhat challenging.

3 weeks ago 3 0 0 0
Candida Genome Database

Check out the new look at e.g.

www.candidagenome.org/locus/ACT1

3 weeks ago 1 0 0 0

Now we ask ourselves, “what can’t we do?”, because adding new tools and functionality is more straightforward than ever, and we want to give the Candida community the best tools we can with the resources we have, to help them best research this group of deadly pathogens.

3 weeks ago 3 0 1 0

this time frame without an AI coding assistant, in this case, Claude. It is a tool, and used in the right way, by someone with 30 years coding experience, provided a 10x or greater increase in the speed of this project. We used to ask ourselves, “what can we do?”, because we have limited resources.

3 weeks ago 2 0 1 0

took a single programmer (who is the most productive programmer I’ve ever worked with - she’s amazing!), working part time on the project, just 2 months. Much of the work was done in a single week. I know people on Bluesky tend to look on AI tools with disdain, but we couldn’t have done this in

3 weeks ago 2 0 1 0
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them more dynamic. We’ve also updated JBrowse to the latest version, added a completely new synteny viewer, and provide new ways to search, as well as sortable and filterable tables of results. I expected this work to take a year or more (the previous code was developed over several years) but it

3 weeks ago 1 0 1 0