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Posts by Gavin Sherlock
We are recruiting 1-2 postdoctoral fellows to investigate the specificity of human anti-influenza virus antibodies, and to determine how these antibodies impact global antigenic drift of influenza viruses.
Join our lab at Penn in Philly. Reach out if you are interested in applying! Please repost!
A doctor costume, honestly, not Jesus…
New OpenFold3 preview out! (OF3p2)
It closes the gap to AlphaFold3 for most modalities.
Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
So pleased to share that this project identifying convergent evolution of aerobic fermentation in a poorly characterized genus of yeasts (Saturnispora) is now out in @embojournal.org
@hittingerlab.bsky.social @rokaslab.bsky.social @glbioenergy.bsky.social
link.springer.com/article/10.1...
New preprint with Bonny Brewer and Raghu's lab. Ku mutant genomes just go bonkers during chemostat evolution, but in very interesting ways! Telomeric amplicons of SUL1 and Y' in yeast are generated by microhomology-mediated break induced replication occurring in cis www.biorxiv.org/content/10.6...
Jack Szostak "All of these things frighten me, and they should frighten you as well. I made the decision to create a life for myself here, because I viewed this as a place that rewarded determination, hard work, and integrity. It still has a chance to be that place again."
It looks like there will be an open postdoc position in my lab soon. I'll be looking for someone with substantial wet-lab experience in microbiology / microbial ecology / evolution / physiology. If everything goes well, an ad will be coming. But if you know someone, ask them to reach out already.
Interested in aging and rejuvenation?
We have a new Research Assistant position to understand aging at the cellular level!!
Come join our team!!! 😎
careersearch.stanford.edu/jobs/life-sc...
You can be opposed to the Iranian regime AND the reckless bombing of school kids.
You can support the troops AND be opposed to sending them into senseless wars.
You are not an antisemite if you decry the Israeli regime’s genocidal rampage.
Don’t let morons impose their idiotic view of the world.
Trump has been in power for 2% of our nation's history but is responsible for 25% of our debt.
It's almost like he's bad at business.
But there’s still no god of course
🧬 Characterized an unnamed #yeast #gene?
1. Name with 3 letters + number (ex. XYZ1) to reflect function.
2. Reserve your unique name at SGD while preparing manuscript www.yeastgenome.org/reserved_nam...
3. Include both ORF & gene names in your publication! 📝
Help: sites.google.com/view/yeastge...
I saw him at a travel convention in January - just a seriously lovely guy and thoughtful, concerned citizen, who literally is putting his money where his mouth is.
The fuckers to the left of me who voted for Jill Stein rather than Kamala, must surely pat themselves on the back on a daily basis at how they’ve fucked over this country.
periodic and timely reminder that "Marisa Tomei" is an anagram for "It's a me Mario"
Really excited that this major work from my PhD is finally published in @plosbiology.org ! In it, we were trying to tackle a fundamental question in evolution - how do genetic mutations map onto evolutionary fitness? (1/n)
journals.plos.org/plosbiology/...
I'm hiring! I have 2 open positions:
🔬 Postdoc
🧪 Research associate
We study how animal multicellularity evolved by exploring the molecular logic of cell adhesion using cell biology, 'omics, and tool-building in non-model organisms.
Come join us!
Details and application links 👇
Please repost
No earth scientists, no astronomers, no one with expertise in biotechnology or medicine, no climate scientists, no materials scientists, no field biologists, no ocean scientists, no atmospheric scientists, no biochemists, no developmental biologists, no evolutionary biologists.
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social
Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback.
rdcu.be/famFj
850 Tomahawk missiles could be $3,060,000,000... That is 3 billion sixty million US dollars.
That is 1224 5 year biomedical research grants. Literally, over 6 millennia of biomedical research.
In our recent study, we created over 1000 intraspecific yeast hybrids by crossing genetically diverse strains and tested how well they grow under harsh industrial conditions such as high ethanol, salt, and organic acids.
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
Hmm - all but 4 papers have disappeared from my myNCBI bibliography, which makes creating a Biosketch through the SciENV platform somewhat challenging.
Now we ask ourselves, “what can’t we do?”, because adding new tools and functionality is more straightforward than ever, and we want to give the Candida community the best tools we can with the resources we have, to help them best research this group of deadly pathogens.
this time frame without an AI coding assistant, in this case, Claude. It is a tool, and used in the right way, by someone with 30 years coding experience, provided a 10x or greater increase in the speed of this project. We used to ask ourselves, “what can we do?”, because we have limited resources.
took a single programmer (who is the most productive programmer I’ve ever worked with - she’s amazing!), working part time on the project, just 2 months. Much of the work was done in a single week. I know people on Bluesky tend to look on AI tools with disdain, but we couldn’t have done this in
them more dynamic. We’ve also updated JBrowse to the latest version, added a completely new synteny viewer, and provide new ways to search, as well as sortable and filterable tables of results. I expected this work to take a year or more (the previous code was developed over several years) but it