MBoC! Can't speak to the cost, but it's community-run and -focused! Guaranteed review for ASCB members...

I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..

A few points and new information that bioscientists may find interesting...

A 🧵

I know what they're getting at with the "could put jobs at risk" but can we focus on the immediate impact? Each suspended round at MRC and BBSRC means about 80 fewer postdoc jobs and the retrospective cuts at MRC add another 30 or so

My excellent collaborator, Giulia Zanetti, is advertising for a post-doc to work on our shared MRC grant. Please consider applying to this great lab with a supportive mentor to do some exciting structural biology.
www.ucl.ac.uk/work-at-ucl/...

And some keratin bands.

If you are interested in membrane trafficking and IDPRs, please join us!

Postdoctoral Research Assistant - MCDB - UOD2016 Closing date: Thursday 6 November 2025, 23:59

Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.

www.dundee.ac.uk/work-for-us/...

Hope it gets back online! Such a great tool.

Predicting protein-protein interactions in the human proteome Protein-protein interactions (PPI) are essential for biological function. Coevolutionary analysis and deep learning (DL) based protein structure prediction have enabled comprehensive PPI identificatio...

Anyone else having trouble accessing the database for this amazing resource? I'm using it for teaching!

Predicting protein-protein interactions in the human proteome | Science www.science.org/doi/10.1126/...

Lovely work! Yeast polytopic proteins have fewer ribosomes than soluble proteins doi.org/10.1016/j.cu... likely reducing ribosome collisions. I wonder if you separate polytopics from single-pass MPs you see differences in codon use. We wondered about initiation but maybe codon use is also important.

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

Multi-scale Molecular Imaging of Human Cells reveals COPI and COPII Vesicles at ER Exit Sites Trafficking from the endoplasmic reticulum to the Golgi apparatus comprises the first steps toward the correct localization of 30% of eukaryotic proteins. Coat protein complexes COPII and COPI are inv...

Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work.
www.biorxiv.org/content/10.1...

Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).

Please apply and/or repost!

jobs.unige.ch/www/wd_porta...

Programme Leader Track - MRC Laboratory of Medical Sciences We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.

We're recruiting junior team leaders @mrc-lms.bsky.social This time we're looking for those working in human metabolic disease.

It's a great place to start your lab. Fantastic colleagues, exciting science, world class facilities. Join us!

lms.mrc.ac.uk/work/vacanci...

Thanks to Josh and all the students and post-docs for a great visit. Such a wonderful community doing great science!

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

HxC Survey on Interdisciplinary Work Online surveys is a powerful, easy to use tool for creating online surveys. Run by Jisc, online surveys is used by over 300 different organisations in the UK...

🚨Interdisciplinary perspectives needed🚨
Have you worked across disciplines in research? We want to hear from you!
Take part in the Healthier Science through Collaboration (HxC) survey. Help shape better, more inclusive research environments.
app.onlinesurveys.jisc.ac.uk/s/edinburgh/...
Please RT.

I think it's a clamp. Provides structural rigidity but via protein-protein interfaces so it might be dynamic/malleable. Four complexes (so far - not privilege to Alex's info): Sec31 (the OG and only essential function in yeast), Sec16 (function unknown), NPC, GATOR.

Justin Krish Williams, Randy Schekman et al. @ucberkeleyofficial.bsky.social show that human cells shed extracellular vesicles in order to repair their membranes. rupress.org/jcb/article/...

#EVs #Exosomes

Our Immune Cell Biology collection emphasizes cellular dynamics, immune regulation, and disease mechanisms. Explore research on the mechanisms of dendritic cell regulation, T cell migration, neutrophil spreading and macrophage motility in tumor invasion, & more: rupress.org/jcb/collecti...
#AAI2025

Latest paper from the lab @cellbiol-mrclmb.bsky.social, Anna's PhD work hot off the press @plosbiology.org ! Using single cell genomics to understand tube morphogenesis, and why it's as important to switch things off as it is to switch them on!

Congrats to Ian Ganley of Dundee University on winning the #BSCB Hooke Medal 🥇for his outstanding work on mitophagy 🎉🎉🌟

Only one week to go until #biologists100 conference!

Check out this pre-conference guide from @biologists.bsky.social @the-node.bsky.social @focalplane.bsky.social @prelights.bsky.social

As my lab's first post on Bluesky. If you are a UK Structural Biologist please come to our one day meeting on Friday 6th December
Lots of talk slots to be selected from abstracts.
Deadline for abstracts is TOMORROW: Friday 15th Nov.
bit.ly/4fDEqfZ

Higher Scientific Officer / Senior Scientific Officer – CLEM & cryoET scientist in Chelsea | The Institute of Cancer Research View details and apply for this Higher Scientific Officer / Senior Scientific Officer – CLEM & cryoET scientist vacancy in Chelsea . Salary : Commencement on the salary range is subject to comp...

Come work with us! Only a few days remaining to apply for the #cryoET / #CLEM facility scientist position at the @icrlondon.bsky.social! #cryoEM
jobs.icr.ac.uk/vacancies/96...

One last shout-out to @jcellbiol.bsky.social who handled an efficient, constructive and very fair peer review process. I know I'm biased because I'm an academic editor there, but this is now my go-to journal for our very best work.

Finally, bioinformatic analysis by @xlichem.bsky.social systematically examined SURF4 export signals across the secretome, finding that cytokines/chemokines and proteases are most likely to access the "fast-track".

...usually co-translational. Stalled translation products STILL bound SURF4 when folding could not have happened. We think this is a fast-track out of the ER for certain classes of proteins that have strong SURF4-binding motifs immediately downstream of their signal peptides.

Third surprise: SURF4 can bind some clients co-translationally. This is not how we thought export receptors should work - we assumed that they would only bind fully folded cargoes, once they were competent for export. But the ER export signal is revealed after signal peptide cleavage, which is ...

Second surprise: SURF4-SEC24A interaction uses two sites on SEC24A, the B-site and the D-site, but SURF4 only occupies the D-site. The B-site interaction is likely driven by a putative co-receptor, TMED10, which also interacts with the lumenal client.