So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure!
www.sciencedirect.com/science/arti...
Our work on the E3 ligase mechanism of target-directed microRNA degradation is now published! Amazing collaboration with Brenda Schulman’s lab led by @jakobfarnung.bsky.social and @elenaslo.bsky.social, with special thanks to @wyppeter.bsky.social, Lianne Blodgett, and Daniel Lin! tinyurl.com/Z8TDMD
The second day of #Biochemistry2026 gets on the way with an exciting talk by Satpal Virdee (@e3chembio.bsky.social). "Next-generation Activity-Based Probes for Ubiquitin and Ubiquitin-like E3 Ligases".
www.nature.com/articles/nch...
#ChemBio #Biochemistry #ChemSky #ubiquitin #TPD #degradation
Paused MRC funding calls to restart earlier than expected.
Applicant-led calls to reopen on 7 April, as research council overhauls grant review structure.
www.researchprofessionalnews.com/rr-news-uk-r...
Many genome-editing tools work by cutting DNA - but the shape of the cut matters. Using genome-wide screening, we show ERCC6L2 is specifically required to maintain repair fidelity at staggered DNA breaks, but not at blunt ends.
www.nature.com/articles/s41...
UK university unions demand pay rise 3% above inflation
Employers describe claim as “extremely challenging” in current financial climate
www.researchprofessionalnews.com/rr-news-uk-u...
Elsevier rejections: libraries ‘had to make cuts somewhere’.
Experts say publisher’s pricing and profits are likely factors in rejection by some universities.
www.researchprofessionalnews.com/rr-news-uk-o...
Redundancies at research-intensive universities double in two years.
www.researchprofessionalnews.com/rr-news-uk-u...
Another great science appointment is coming up with @centromellone.bsky.social, Michele Pagano and Gergely Róna!
Join us live on Tuesday, March 3rd at 5pm (Rome) / 11am (NYC).
Zoom link: uniroma1.zoom.us/j/95149984403
Register here to stay in the loop: docs.google.com/forms/d/e/1F...
Job losses at UK research-intensive universities double in two years.
Exclusive: Scale of redundancies branded a “disaster”.
www.researchprofessionalnews.com/rr-news-uk-u...
DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!
📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’
📅22-25 June 2026
📍CRUK Scotland Institute, Glasgow
🎟️Early Bird registration closes on 1 April
🔗 www.beatsonconference.org
#BICC2026 #CancerResearch #Immunology
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief
By Islam et al., and Luca Busino
➡️ genesdev.cshlp.org/content/early/2025/12/08...
#PROTAC #KRAS #cancer #cancertherapy
Yep
Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community!
We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.
Cara Maria Carmela Masi,
desidero ringraziarti per la menzione:
www.ecodicaserta.it/notizie/cult....
Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.
Three UK research councils suspend funding opportunities
“Temporary block on grant applications by MRC, BBSRC and EPSRC heightens concerns over funding cuts”
Or:
Scientists are furious that they are learning of pauses to their main access to funding through press snippets rather than first hand dialogue with Uni research offices………..
Nature's Impact Factor is in the Epstein Files. Really.
That would be catastrophic
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
SS18::SSX activates Polycomb target genes without BAF ❌
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➡️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
Academic publishing is now one of the most lucrative industries per unit of input
theconversation.com/when-science...
Am spending my Saturday reading grant proposals and feeling such pessimism about the state of uk science funding. So many good ideas, so many talented researchers, so incredibly little investment 😞
Leeds researchers have secured two major Wellcome Trust Discovery Awards.
The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.
🔗Full story: bit.ly/4oW3D99
@astburycentre.bsky.social @universityofleeds.bsky.social
I have a PhD position available with start date September 2026 at the University of Manchester.
Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes
Due to funding requirements, this position is for UK home students only.
www.findaphd.com/phds/project...
Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...
Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...
Cara Maria Carmela Masi,
desidero ringraziarti per la menzione:
www.ecodicaserta.it/notizie/cult....
Il Liceo Domenico Cirillo ha avuto un ruolo importante nel mio percorso. L’Italia possiede un patrimonio culturale di straordinario valore, che mi auguro continui a essere custodito e valorizzato.
