Pseudouridine selects RNAs for extracellular transport RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...

RNAs outside of cells?! How did they get there?

(Thread coming soon 👀)

www.biorxiv.org/content/10.1...

Improved spike-in normalization clarifies the relationship between active histone modifications and transcription www.biorxiv.org/content/10.1101/2025.11....

Programmed DNA elimination was present in the last common ancestor of Caenorhabditis nematodes www.biorxiv.org/content/10.1101/2025.10....

Argonautes and small RNAs associated with nematode programmed DNA elimination www.biorxiv.org/content/10.1101/2025.10....

This work highlights that parasites 🪱 can adapt genomic fossils into tools for cross-species communication 🧬

We also found that non-autonomous copies and soloLTRs are the preferred sources of secreted exWAGO small RNA guides, suggesting that degradation is followed by co-option for cross-species RNA communication.

Using comparative transcriptomics, we demonstrated that exWAGO regulates a broad set of transposable elements, with a deep and conserved link to the modulation of LTR retrotransposons.

Comparative transcriptomics reveals an extracellular worm argonaute as an ancestral regulator of LTR retrotransposons. Safeguarding the genome from non-self elements is essential for reproduction, development, and ageing. One of the major threats to genome integrity is Transposable Elements (TEs), which can be post–tr...

Thrilled to share our preprint on the ancestral function of the secreted Argonaute exWAGO 🧬🐙
www.biorxiv.org/content/10.1...

This work highlights that parasites 🪱 can adapt genomic fossils into tools for cross-species communication 🧬

We also found that non-autonomous copies and soloLTRs are the preferred sources of secreted exWAGO small RNA guides, suggesting that degradation is followed by co-option for cross-species RNA communication.

Using comparative transcriptomics, we demonstrated that exWAGO regulates a broad set of transposable elements, with a deep and conserved link to the modulation of LTR retrotransposons.

The impact of rearing environment on C. elegans: Phenotypic, transcriptomic and intergenerational responses to 3D enriched habitats www.biorxiv.org/content/10.1101/2025.09....

Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades | PNAS Rates of phenotypic evolution vary across traits, and these evolutionary patterns themselves evolve. Understanding how development contributes to s...

!

Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades

www.pnas.org/doi/10.1073/...

Emergence and stabilisation of a neo-Y chromosome in nematode species with rare males www.biorxiv.org/content/10.1101/2025.07....

electron microscopy image of a C elegans on a yellow background

🧬June's most-read Genetics paper independently validates previous research showing that #CElegans can inherit learned pathogen avoidance: buff.ly/HQgprLp

#TREnD2025 virtual day is here!! First talk starting now! 🥳

Super excited to see our work shared with the scientific community! We know #Argonaute proteins can be extracellular, but can they be transferred to recipient cells and can they function? Happy reading!