Very exciting new paper from @radykm.bsky.social!

A headline: Scientists have discovered a 'third state' between life and death

"Postdoc in the job market"

“Preliminary data center”

When I delete slide 137 from my presentation because I might run out of time

PancMidwest 2025 was truly fantastic! Two days of science, catching up with old friends and getting to know more amazing people across the Midwest. Thank you so much for organizing @mpm-lab.bsky.social and Dr. Tim Frankel! @umich.edu @henryfordhealth.bsky.social 🧪 @lyssiotislab.bsky.social

Now online in Cancer Discovery @aacrjournals.bsky.social: Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Protumorigenic T Cell Polarization - by Brian Griffith, Timothy Frankel, and colleagues doi.org/10.1158/2159... @umich.edu

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6

So grateful and excited to partner with the Stephenson Global Pancreatic Cancer Research Institute to advance our collaborative program targeting lysosome and Kras metabolism in pancreatic cancer!

michmed.org/rwVDK

This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...

IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity The mammalian endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is essential for cellular homeostasis and plays key roles …

www.sciencedirect.com/science/arti... @drbadbug.bsky.social @teresaomeara.bsky.social Overall, our findings illustrate non-canonical IRE1α activation during infection and a function for IRE1α in supporting organelle contact sites to safeguard against rapidly growing microbes.

🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥

We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼

Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!

Congratulations @djcalebc.bsky.social and all the other authors! It was amazing seeing this project develop over the last few years!

(A) Oxidative mitochondria, in red, retain cristae to house the electron transport chain, comprising complexes CI, CII, CIII, CIV, and CV. Glutamine metabolism in the oxidative tricarboxylic acid (TCA) cycle fuels ATP synthesis. Oxidative mitochondria can be identified by the retention of CV expression. Reductive mitochondria, in blue, lose cristae and use reducing potential to drive reductive ornithine and proline biosynthesis from glutamine. Reductive mitochondria distinctly present with pyrroline-5-carboxylase synthase (P5CS) filaments. (B) Reductive mitochondria in which P5CS has been oligomerized into filaments are sequestered via mitochondrial fission, a process that can be mediated by dynamin-like protein 1 (DRP1). Mitochondrial fusion sequesters oxidative mitochondria. This process can be driven by mitofusin 1 and 2 (MFN1/2).

ONLINE NOW! Subcellular mitochondrial heterogeneity enables opposing metabolic demands, by @brandontwchen.bsky.social, Yatrik Shah and @lyssiotislab.bsky.social, discussing the recent work by @keunwooryu.bsky.social et al.
Read it for free until March 19th at:
authors.elsevier.com/a/1kWLq3jDgW...

The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!

My family: Do you have any New Year's resolutions?

Me: 2.6 Å

New TrendsinBiotech w/ Shea Lab, led by Kate & Michael. We cover concepts bridging nano/materials and immunity; e.g., nanoparticles can be designed with immune-modulatory metabolites (poly-lactate) 😎

t.co/3FQRYgsMvv

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

This was truly a collaborative effort between so many groups at the University of Michigan and I couldn’t be more thankful to be part of such a great research environment!

In short, we characterized the isolated Klebsiella oxytoca strains (UMKO1) using genomic sequencing, metabolomics and murine tumor explants grown in TIF media (TIFM). A physiological media developed by the Muir lab @muirlab.bsky.social

Our new preprint is now online! Here we describe in detail our strategy to isolate bacteria and fungi from pancreatic cancer patients. We also characterized a newly isolated Klebsiella oxytoca strain (UMKO1) in more detail. Thank you to all the co-authors and mentors! @lyssiotislab.bsky.social

Hi #immunosky @rafrancescone.bsky.social and I are looking for a postdoc candidate interested in immunology, with experience in flow cytometry, to run projects exploring mechanisms of immunosuppression in pancreatic cancer. Come to beautiful Michigan! Official announcement soon. DM us

#PancreaticCancer research starter pack.
65 of 150. Room for 85 more on this 1st starter pack.
Who did I miss?
go.bsky.app/FDafAW

If you want to learn something on Friday, please join us in person or virtually for the 4th annual Henry Ford Pancreatic Cancer Symposium! To see the program and to register, go to hfhs.cloud-cme.com/course/cours...