🚨 Excited to share our latest preprint!
@mgarnett.bsky.social @mattcoelho.bsky.social
We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments.
#CRISPR #BEstimate #BaseEditor

Congrats @luciabarmar.bsky.social and team! 🎉

Our review "Predicting gene expression from DNA sequence using deep learning models" is finally out! 🤗

#ICLR2025 Marine Le Morvan presents "Imputation for prediction: beware of diminishing returns": poster Thu 24th
arxiv.org/abs/2407.19804

Concludes 6 years of research on prediction with missing values: Imputation is useful but improvements are expensive, while better learners yield easier gains.

We’re looking for Computational Scientists to join our team in advancing cutting-edge research at the intersection of spatial genomics and AI.

Check it out:
lnkd.in/ezruccHF
lnkd.in/e2siGM_9

Pre-print alert!! Did you know that exploration of loss and gain of eQTL regulation in normal versus disease condition from scRNAseq can reveal pos-transcriptional regulatory mechanisms (e.g. miRNA)? Have a look at our work, led by awesome @tdwinter.bsky.social, in which we focus on human islets.

[SAVE THE DATE] MLCB 2025 is happening Sept 10-11 at the NY Genome Center in NYC!

Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections!

Submission deadline: June 1
More details: mlcb.github.io

Help spread the word—please RT! #MLCB2025

Shining a light on cell biology of the nucleus with single-cell sequencing From the preservation of genomic integrity to the regulation of RNA translation, nearly all cellular processes are regulated in a cell context-depende…

Happy to share this concise review and outlook for single-cell sequencing methods to unravel cell biology of the nucleus! Big shoutout to my friend and former colleague Peter Zeller for sharing the work!
www.sciencedirect.com/science/arti...

#MLCB2025 will be Sept 10-11 at @nygenome.org in NYC! Paper deadline June 1st & in-person registration will open in May. Please sign up for our mailing list groups.google.com/g/mlcb/ for future announcements. More details at mlcb.github.io. Please RP!

Dream to Manipulate: Compositional World Models Empowering Robot... A world model provides an agent with a representation of its environment, enabling it to predict the causal consequences of its actions. Current world models typically cannot directly and...

🔥1/4 #ICLR2025 Dream to Manipulate: Compositional World Models Empowering Robot Imitation Learning with Imagination, integrating real-time photorealism &physics simulation for enhanced robot learning openreview.net/forum?id=3RS... +L. Barcelona, @zadaianchuk.bsky.social,@samuelepapa.bsky.socialetal

Sequencing technologies to measure translation in single cells - Nature Reviews Molecular Cell Biology Recent sequencing-based methods, including novel ribosome profiling, ribosome affinity purification and spatial translation methods, have enabled the measurement of translation at single-cell resoluti...

Several new technologies have enabled translation profiling in single cells. In our article in @natrevmcb.bsky.social, Alexander and I discuss these single-cell methods for measuring ribosome profiles, ribosome-associated transcripts, and spatial translation 🧵 www.nature.com/articles/s41...

Mapping cells through time and space with moscot - Nature Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal...

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Webinar on "Tracking replication fork dynamics: A deep dive into scEdU-seq"

Do not miss out on this webinar on @bio-protocol.bsky.social to see what we have been up to in quantifiying single cell DNA replication dynamics using scEdU-seq ! 🚀 Register now!

bio-protocol.org/webinar/deta...

Just over the moon that the grant, wrote with my amazing long-time friend @lleonie.bsky.social, has been funded by @novo-nordisk.bsky.social for an incredible €2M! 🤯 Huge thanks to Alexander and @grothlab.bsky.social for their support and guidance throughout. Thrilled for the journey ahead! 🎆✨