Now out in its final form! www.science.org/doi/10.1126/...

Engineering Spatial Control of Bacterial Organelles Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

New preprint from the Vecchiarelli Lab! 🧵

Congratulations to first author Dr. Claire Dudley!
@claire-dudley.bsky.social

Claire uncovered a critical player in the organization for the photosynthetic cytoplasm of cyanobacteria - polyphosphate! #polyP

www.biorxiv.org/content/10.6...

I have officially started my new position as a Senior Research Scientist at the National Institute of Infectious Diseases (NIID) 🇯🇵. My new research group will focus on the cell/molecular biology of parasitic Excavata & amoebae (incl. Trypanosoma, Naegleria, Acanthamoeba, & more) (1/3)

Pablo Villar et al discover male octopus mating arms are sensory organs used to find females, navigate internally to the oviduct & deliver sperm. From behavior to structure, these findings offer a framework for how sensory systems shape reproduction & species barriers
www.science.org/doi/10.1126/...

My PhD paper on my beloved cycads and beetles on the cover of Science!!!

Check out how we studied thermal infrared as a pollination signal, from molecular mechanisms to the wonders of behavior...

science.org/doi/10.1126/...

🚨 excited to share our latest preprint on bioRxiv, led by the soon-to-be Dr. Guy Kunzmann!

We tackle a striking case of conditional dependence on UFMylation, a UBL modification pathway whose contributions to cell fitness have been a bit of a "black box." 🧵

Out now–our work on bacterial cGAS-like enzymes making 2′,3′-cGAMP! Read Uday's thread for updates since the preprint including determining our lab's first protein structure and developing a new system to study bacterial STING homologs in phage defense👇

The cover art, inspired by the classic Pink Floyd cover art from "The Dark Side of the Moon", depicts a white noise protein oscillation being filtered by a yeast expressing a specific synthetic circuit design into more precise, single-color waveforms. This visual echoes the noise-guided design strategies associated with Bolshakov et al.

Congratulations to my student Dennis Bolshakov and his coauthors @weix.us, Tommy, and @born2raisecell.bsky.social on making the cover of ACS Synthetic Biology! A great paper and an awesome cover 🥳 pubs.acs.org/doi/10.1021/...

This is super cool!! This is a kind of ciliate called a suctoria (this one happens to be Acineta sp.) and it’s sucking up the contents of this egg! You can see it consuming the mush on the left hand side of the ‘martini glass’ (timelapse)
#marineplankton 🦑

Morphological and behavioral diversity among Euplotes, as documented by the PhD students

Some molecular machines, like ribosomes, can persist for long periods of time in cells.

Could molecular aging of ribosomes shape how proteins are made?

In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10)

www.biorxiv.org/content/10.6...

Awesome representation from @uwmadscience.bsky.social at the @asbmb.bsky.social #ASBMB2026 meeting in DC! #ScienceServesUsAll

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...

In the context of carboxysome positioning, @azaldegui.bsky.social found that the aggregation of a bacterial microcompartment is prevented by a self-organizing DNA-binding ATPase! #SingleMolecule #SuperResolution #Microscopy
with @cellforganized.bsky.social and JianLiu
doi.org/10.64898/202...

That smile speaks volumes - as always. Congrats Felix Hol (a lab alum) to be selected for TEDFellows class of 2026. From the swamps at Stanford to villages in Madagascar - I have so many memories with Felix - but his joyful laugh is one that rings again and again. Let's go catch some mosquitoes.

Congratulations to our grad student Lifei Jiang!!!!! Well deserved

Huge congratulations to my student Rohith Rajasekaran @born2raisecell.bsky.social (now a postdoc in Kole Roybal's lab at UCSF) on being selected for a Weintraub award! Super proud of you and all the work you've done!

Now in Nature Comms w/ @ritatewari.bsky.social, Pushkar Sharma & @ryanase.bsky.social (thanks!). Aurora kinases fascinate me: single ancestor - parallel duplications in eukaryotes - paralogs with distinct functions. ARK1 is the CPC Aurora in the malaria parasite. rdcu.be/e5NRT #plasmodium #mitosis

Waaaa this is so cool!!!! My dreams of science van-life just got more realistic...

🤩to see this behemoth of a story out !
Pushed by @nikobiota.bsky.social & the Amazing @embl.org AML Team (Tina, Michael, Paulina) and in Co. with the Best #science #family you can dream of!

This truck was #home, for weeks in a row & in my heart for a lifetime.

www.biorxiv.org/content/10.6...

Fantastic look into sub-cellular patterning and functional organization of ciliary arrays in Paramecium! This is a great platform for decoding the mechanistic details that organize these sub-cellular layouts as well-- congrats @guille-rochelle.bsky.social and @daphnelaan.bsky.social !!

Excited to share our new preprint exploring how Paramecium achieves diverse flow functions, i.e. feeding and swimming, simultaneously. This work was spearheaded by our ExM expert, PhD student Daphne Laan @daphnelaan.bsky.social :
www.biorxiv.org/content/10.6...

Great to see our paper on light-intensity dependent swimming patterns in #Chlamydomonas out now in Phys Rev Lett. as an Editors' suggestion! With a nice commentary by @philipcball.bsky.social.

Chlamy actively modulate the beat planes of their #cilia!
journals.aps.org/prl/abstract... #protistsonsky

Evolution of error correction through a need for speed Kinetic proofreading is a class of error-correcting mechanisms in biology that expend energy to avoid mistakes during replication, transcription, and translation. Proofreading is typically assumed to ...

@science.org Evolution of error correction through a need for speed | Science #evolution 🧬🔬 www.science.org/doi/10.1126/...

Nice! I always share your 'frustrated gene' ideas when I teach the eukaryotic mRNA processing section of our intro biochem class; helps rationalize the "why" and also just kinda blows their minds. I'll fold this new example in alongside the cap snatchers, SCANRs, etc.

A 🆕 #Ichthyosporea story
Led by@margaridaaraujo.bsky.social, in Co. @gautamdey.bsky.social & @hiralshah.bsky.social+🔥team across @embl.org & @sciencesunige.bsky.social
We finally have a look at what #microtubules are doing during #cellularization in #Sphaeroforma
▶️ tinyurl.com/MTSARC
#ProtistsOnSky

Awesome seminar today by UCSF's @willowcoyote.bsky.social! He is not afraid to blaze his own trail, redefining paradigms along the way!

Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. 👀 Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!

www.biorxiv.org/content/10.6...

Thank you @mollyherring.bsky.social for the stunning showcase 😍

Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠

#ProtistsOnSky #MicroEvoSky 🧪🔬🌍

@dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org