🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo

PREPRINT ALERT !!!
Excited to share our #reptile #embryo cryopreservation method optimised on peri-gastrulation veiled chameleon embryos! This lays the foundation for functional studies & reptile #conservation efforts!
#devbio #squamates #evodevo

www.biorxiv.org/content/bior...

My main gripe with the alphafold example is how it shows you need decades and decades of high quality data, well structured, open and accessible to train a model -- and yet they always gloss over it and pretend it's just AI and magic. No, we need to continuously invest in real data and FAIR data.

a scientific diagram in black and white showing sections of embryos of Hemimysis lamornae, a small shrimp-like crustacean that lives in the seas around the UK.

In 1928, Sidnie Manton FRS published ‘On the embryology of a mysid crustacean, Hemimysis lamornae’, a landmark paper in descriptive arthropod embryology. See more on our #WomenInSTEM publishing timeline: royalsociety.org/news-resources/women-in-...

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

Differential fates of Kazald gene quartet: Ancestral roles in skeletogenesis and regeneration to putative innovations in fish and birds Natural sciences; Evolutionary biology; Evolutionary developmental biology; Evolutionary history

Just published from our group!
Study of a family of genes, one of them previously associated to regeneration in axolotls (Kazald2) and now we associate its expression during regeneration ancestral of bony vertebrates.

www.cell.com/iscience/ful...

The molecular evolution of vertebrate organs Nature Ecology & Evolution - This Review discusses recent advances in the molecular evolution of vertebrate organs, including rates of evolution of organs and cell types, molecular mechanisms...

Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here:
rdcu.be/e5EgU
#EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜

Investigate regeneration and repair using whole animals or organ/tissue systems at EMBO Workshop "The molecular and cellular basis of #regeneration and #TissueRepair" in #Krems, AT, 21–25 Sep 2026.

Deadline: 20 May

https://meetings.embo.org/event/26-tissue-repair
#EMBORegeneration #EMBOevents 🧪

Stoked that this paper, summarizing a vast series of experiments from past and present members of the team is out. A great way to end this year.

www.nature.com/articles/s41...

Proud of organizing the EMBO Regeneration Workshop 2026 in Krems, in the heart of Austria, together with @simoesfilipa.bsky.social, @jordisolana.bsky.social, Anna Jazwinska, Mansi Srivastava, MaxYun and Juanma González-Rosa! Registration is open! #EMBORegeneration
meetings.embo.org/event/26-tis...

Programmatic design and editing of cis-regulatory elements The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!

In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.

www.biorxiv.org/content/10.1...

Schematic of limb regeneration in axolotl, with growth controlled by two oppositely oriented morphogen gradients (SHH, FGF8).

Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social

1880s kids most likely had a better understanding of organismal structure

Freshly out at @natcomms.nature.com ! Our @univie.ac.at @awi.de @viennabiocenter.bsky.social @ercgrantees.bsky.social research into neurogenic plasticity of adult worm brains, and similarities in stem cells supporting growth of camera-type eyes. www.nature.com/articles/s41... [1/7]

Who's this cutie? 😄

Ectopic head regeneration after nervous system ablation in a sea anemone Via genetic ablation of neurons, Mazloumi Gavgani et al. show that the nervous system is essential for defining axial polarity during whole-body regeneration in the sea anemone Nematostella vectensis.

Our paper on the role of neurons in Nematostella head regeneration is now out at @currentbiology.bsky.social Big thank you to all collaborators, it was a pleasure!

Ectopic head regeneration after nervous system ablation in a sea anemone: Current Biology www.cell.com/current-biol...

Exactly. So that I know when to avoid it.

Jutussa arvoidaan, että ero johtuisi erosta tutkintojen pituudessa (Suomi 3v vs USA 4v).

Joku hullunrohkea voisi sanoa, että se johtuu siitä, että USA opettaa paremmin kuin koulutuksen mallimaa Suomi.

Ylen jutusta "Suomalaisilla opiskelijoilla on korkeakouluopintojen alussa keskimäärin paremmat kriittisen ajattelun taidot kuin yhdysvaltalaisten verrokkiyliopistojen opiskelijoilla. Alemman korkeakoulututkinnon loppuvaiheessa merkittävää osaamiseroa ei enää ole."

The Spiralian Organiser
(enriched with dpERK1/2)
🪱🎃🪱🎃🪱

#DevBio
#EvoDevo
#SciArt

*almost* all

What is the unit of morphological evolution, and how many of these units amount to almost all?

Can't believe it — my first‑author paper is out and my image graces the cover of @dev-journal.bsky.social 🎉

Here, we reveal how early developmental programs shape and maintain #zebrafish gill architecture throughout life
🔗 journals.biologists.com/dev/issue/15...

#FluorescenceFriday #LifelongDevSI

Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation Development of alternative methods for analysis of reproductive toxicity is a challenge that requires the characterization of mechanistic endpoints li…

Exploring the potential of Schmidtea mediterranea as a model for reproductive toxicity through analysis of sterility caused defective m6A RNA regulation - ScienceDirect
www.sciencedirect.com/science/arti...

Just going to leave this rather frightening reference about the change in global mammalian biomass from 1860 to now here. 😳🧪

www.nature.com/articles/s41...

Been there, done that.

Probably sunshine

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

Harvard FAS Cuts Ph.D. Seats By More Than Half Across Next Two Admissions Cycles | News | The Harvard Crimson The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for…

The Faculty of Arts and Sciences slashed the number of Ph.D. student admissions slots for the Science division by more than 75 percent and for the Arts & Humanities division by about 60 percent for the next two years.

William C. Mao and Veronica H. Paulus report.

www.thecrimson.com/article/2025...

Nobel Prize in Physiology or Medicine 2012 The Nobel Prize in Physiology or Medicine 2012 was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent"

Honouring the life of Sir John Gurdon, who died earlier this week: awarded the Nobel Laureate in Physiology or Medicine for seminal work carried out in Oxford Zoology (now @biology.ox.ac.uk) showing that mature cells could be reprogrammed to become pluripotent.

www.nobelprize.org/prizes/medic...