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Molecular pathways for learning in the single-cell Stentor coeruleus Rajan et al. explore the molecular basis of habituation in the unicellular organism Stentor coeruleus using a combination of pharmacological methods, proteomics, transcriptomics, and RNAi. These exper...

Link to paper in @CurrentBiology. Thank you to co-authors @aralbright.bsky.social @gautamdey.bsky.social and more. @ucsfhealth.bsky.social @ucsfmedicine.bsky.social @uofcalifornia.bsky.social
www.cell.com/current-biol...

3 hours ago 6 2 1 0

Really excited to finally share this more widely.

This is exactly the kind of work we hoped the cooperative could support—helping turn strong community momentum around #OMEZarr into something more coordinated and sustained.

Very curious to hear what people think.

10 hours ago 11 5 0 0

Nice artwork on the poster

12 hours ago 4 2 0 0

Ha! Vaults.

23 hours ago 2 0 0 0

Just published 📢

@herveturlier.bsky.social and I show how the most advanced unfitted finite elements can increase our capacity to investigate fundamental problems in cell morphogenesis.

👉 Link to paper: doi.org/10.1016/j.jc...

🚀 Stay tuned for future applications to animal systems!

3 days ago 16 1 0 1
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New Pre-Print Alert!

Evolving initial conditions: an alternative developmental route to morphological diversity

with Shannon Taylor and @jamesehammond.bsky.social

www.biorxiv.org/content/10.6...

1 day ago 123 48 6 2
Video

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~
www.biorxiv.org/content/10.6...

2 days ago 134 39 3 3

Our #UExM efforts with @gautamdey.bsky.social & @moorefound.bsky.social featured in @nature.com this month.

Beyond the #science, every image is a thing of beauty.

I think a world-tour exhibition has to happen at one point.

#Expansion #Microscopy

2 days ago 47 17 0 0
Three female researchers discuss data displayed on dual monitors in a microscopy workspace with keyboards, mouse, and electronic equipment on the desk.

Three female researchers discuss data displayed on dual monitors in a microscopy workspace with keyboards, mouse, and electronic equipment on the desk.

Two female researchers working at a computer displaying a 3D scientific visualization on a large curved monitor in a modern office.

Two female researchers working at a computer displaying a 3D scientific visualization on a large curved monitor in a modern office.

Two young researchers examining an object with tweezers in a lab setting near a sink and hygiene supplies.

Two young researchers examining an object with tweezers in a lab setting near a sink and hygiene supplies.

Group of participants in a lab setting reviewing microscopy images on computer screens and looking at printed diagrams during a practical course.

Group of participants in a lab setting reviewing microscopy images on computer screens and looking at printed diagrams during a practical course.

We are having a very hands-on week at the @embo.org #cryoFIB & #cryoET course 🔬

Our participants are learning about sample vitrification, lamella milling, FLM, lift-out, data acquisition and more!

We are learning by doing, troubleshooting, and sharing expertise across labs. 🧪

5 days ago 24 5 0 0
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EM from Figure 3 of Soumi Dutta and Vladimir Gross's preprint showing structure of tardigrade eye.

EM from Figure 3 of Soumi Dutta and Vladimir Gross's preprint showing structure of tardigrade eye.

Whoa. Check out this tardigrade eye, comprised of just four cells, one of which has a cilium (CI) that expands into a labyrinth (orange, outer segment equivalent?) with ciliary Opsin. See preprint from Soumi Dutta, Vladimir Gross, Georg Mayer and colleagues:
www.biorxiv.org/content/10.6...

3 days ago 25 9 2 0
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These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9

3 days ago 185 53 4 5
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Happy Golgi Day

3 days ago 46 14 1 0
Science | AAAS

Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

4 days ago 182 79 7 8

19th PLM! wow Great to see this @cam.ac.uk tradition going on. PLM was there right at the start of a new era

4 days ago 8 3 0 0

Now published. Congrats to Soham and all co-authors! www.science.org/doi/10.1126/....
@embl.org

4 days ago 52 20 2 1

Congratulations

4 days ago 1 0 0 0

Just published in @science.org 🚀

By controlling how cells align, we show that living nematic tissues can be programmed to generate forces and fold into predictable 3D shapes.

A new platform for tissue engineering and the design of smart active materials! 🫆

www.science.org/doi/10.1126/...

6 days ago 80 32 8 2

Eating its own tail, the central dogma of molecular biology has come full circle!
🧬

5 days ago 36 6 0 0

Valid point

5 days ago 0 0 0 0
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Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe - Nature Neuroscience The authors characterized the spatial origin of Drosophila medulla neurons, completing their previous characterization of the temporal and Notch origins of these neurons and allowing them to correlate...

Félix Simon's paper is out in its final form 😍
When we got into (extreme) detail in the temporal and spatial patterning of neuroblasts, Félix asked a simple question "sure, but how does this translate into neuronal cell fate?". www.nature.com/articles/s41...

6 days ago 42 23 3 3

Which, as you probably know, defeats even the thermodynamic death of the Universe. 😀

5 days ago 2 0 1 0
Pictures from Fanny Martinez Real and Stefan Mundlos🙏

Pictures from Fanny Martinez Real and Stefan Mundlos🙏

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This year, the annual symposium of my Chaire @college-de-france.fr will be on The Evolution of Developmental Mechanisms. An impressive lineup of speakers and weirds animals, including humans. Free entrance and coffee breaks. Come, have a seat, relax and enjoy the best possible basic science🤘RT🙏

6 days ago 31 18 0 0

Hope

5 days ago 2 0 2 0

BTW, this is finally a good, slightly adversary, discussion thread on Bluesky, I miss those from the Twitter days. But I see why this is now. The Bluesky interface is super clunky for following the threads...

5 days ago 2 0 0 0

But the point of retroactivity here was precisely to limit the influx in 2027. Me thinks.

5 days ago 1 0 2 0

Not sure what you mean. There are limits; in fact, they were made more explicit with this update. But I may have misunderstood you...

5 days ago 0 0 0 0
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If this were the case, the new exclusion criteria would be explicitly stated. I read this as applying specifically to the 2027 call.

5 days ago 0 0 1 0

This would only increase the volume and make panel workload impossible

5 days ago 0 0 1 0
Pioneering Research – Exploring the Unknown Unknown With the programme "Pioneering Research – Exploring the Unknown Unknown", the Foundation supports groundbreaking and risky research ideas with high scientific relevance. Online Q&As: 11 June and 16 Ju...

True leadership comes from a car manufacturer… www.volkswagenstiftung.de/en/funding/f...

5 days ago 2 0 0 0

Even the supposedly leading institutions are thinking more about bottom line, where the funding is, what politicians mandate, what they perceive society wants, instead of leading the way towards fundamental understanding of how nature works (which I believe they should do).

5 days ago 2 0 1 0