Big picture: better stories should follow better evidence, not the other way around.
Read the piece & join the discussion:
authors.elsevier.com/a/1lt2w5Eb1B...
#TrendsMolMed #redox #evidence

The need for greater precision in redox biology has been recognized. To break free from the ‘indiscriminate antioxidant use age’ in society & from the ‘command of publicly approved science’ in research, repurposing of the oxidative stress narrative is warranted
#oxidative_stress

Oxidative stress isn’t just “bad”. Reactive species can be essential signaling molecules - context, dose, timing, and location matter.
Yet we still lack clinical thresholds to define conditions like eustress vs distress.
#RedoxSignaling #antioxidants

Early, catchy narratives spread fast, then resist correction, especially once industry, media, and public expectations lock them in.
This science↔society loop can stall progress.
#Narratives #MolecularMedicine #SciSoc

Our new paper with @mg-nikolaidis.bsky.social out in
@cp-trendsmolecmed.bsky.social
“Science captured by storytelling: the oxidative stress narrative”
DOI: authors.elsevier.com/a/1lt2w5Eb1B...

🚨LEAD FEATURE ARTICLE🚨 November 2025✨

We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.

It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...

Your intuitions about individual responses to training are probably wrong 😉

👇🧵 1/11

This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...

2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org
Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track)
@sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social

I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres Abstract figure legend Sprint interval training (SIT) is a popular time-efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all-out cycling sprints) over 3...

Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains.

Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental
physoc.onlinelibrary.wiley.com/doi/10.1113/...

After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...

Dichotomization I’m writing a paper about “An Empirical Assessment of the Cost of Dichotomization” together with Frank Harrell (@f2harrell) and Stephen Senn (@Stephen). In this paper, we quantify the information loss...

There's a nice discussion at Frank Harrell's datamethods:

discourse.datamethods.org/t/dichotomiz...

Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim.

Date: Tuesday 6th May 2025
Time: 15:00 CET
Where: Online (link in bio)

#MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity

Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...

The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...

James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal.
onlinelibrary.wiley.com/doi/10.1111/...

📢 Exciting Webinar Alert!

Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social.
See you there!

Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial - European Journal of Nutrition Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been inv...

Good to see this paper finally published in EJON, after a strange prior experience with another journal, "Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial" link.springer.com/article/10.1...

Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such.
www.biorxiv.org/content/10.1...

Great redox researcher to follow and excellent review in the redox biosensors field!

Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.

Increased exercise tolerance in humanized G6PD-deficient mice Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu

G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social

ashpublications.org/bloodadvance...

Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social
#redox #supplements #sports #evidence

Evidence-based sports supplements: A redox analysis Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largel…

“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues.

www.sciencedirect.com/science/arti...

10/17

“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance” in FRBM is complete! Reviews on exercise physiology, muscle plasticity, molecular mechanisms and more! All #openaccess!
#myoblue #muscle #exercise

www.sciencedirect.com/special-issu...

A long🧵: 1/17

The editorial mentoring programme of the @sfrre-ecr.bsky.social is now running! Seeing initiatives we envisioned coming to fruition is always quite emotional! Wishing the best of success to the mentees for their journey ahead! Many thanks to senior editors of Redox Biology, FRBM and RBC, &elsevier!

New preprint: “Three-Sided Testing to Establish Practical Significance: A Tutorial” (osf.io/preprints/ps...) with @FitzgeraldJack_, proposing an upgraded version of the TOST equivalence test 🧵

99% of the circulating cells, 84% of the cells in the body are RBCs. These 25 trillion cells shed 1 vesicle/h (more under stress). With >250 transporters and receptors, RBCs pick up/release metabolites, at times even against gradient, throughout the body. Yet, they are not part of 👇 conversation