Schwarbs on pace for a 162-homer season. Ring the bell. #Nof1

Analysis resources

#statstab #471 Analysis Resources for N-of-1 research

Thoughts: Some cool and some questionable stuff, but a good place to start looking.

#Nof1 #analysis #resources #estimand #methods #sced #stats #smallsample #scd

www.nof1sced.org/analysis

A clinician's guide for conducting randomized trials in individual patients - PubMed In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a partial guide and have not been or cannot be carried out for most clinical disorders. However, randomized controlled trials (RCTs) in individual pat …

#RandomizedTrials in individual patients – #Nof1 #RCTs – provide the highest certainty evidence of treatment impact in an individual. The epitome of best clinical practice. This article gives a step by step for setting up and running an N of 1 trial.

pubmed.ncbi.nlm.nih.gov/3409138/

Perfectly baked pumpkin pie cooling on a rack. Looks good enough to eat. 😆

It was a successful outcome for my substitute pie weights using a Pyrex bowl with some water. 🥳
The pie crust did stick to the foil a little bit when I pulled it off, so next time, I'll spritz it with some cooking oil spray.
Pumpkin pie for the win! 🥰

#PumpkinPie 🧁 #Nof1 #Baking #Research

“단 한 명을 위한 치료의 기적”…‘뉴스토리’ K헬스 혁신 도전→미래 의학의 조건 비춘다 #뉴스토리 #K헬스 #Nof1 아이의 이름이 불리는 순간, 한 가족의 희망이 작게 울린다. SBS ‘뉴스토리’는 이번 주, 누구도 쉽게 가닿지 못했던 ‘기적’의 현장으로 시선을 돌린다. 희귀질환이라는 어려운 벽 앞에서 멈출 수 없었던 사람들, 단 한 번뿐인 기회와 나지막이 이어지는 일상을 따라간다. ‘진짜로 일어날지도 몰라, 기적’ 특집은 단 한 명만을 위한 맞춤 치료가 가진 의미를 진중하게 되짚는다. 5살 라온이에게 내려진 선천성 당단백질 형성 이상증 진단, 그리고 그 가족의 고요한 절망 위로 전해진 단 한 사람만을 위한 치료제 개발의 제안은, 아직 풀리지 않은 의료의 난제들이 결코 벽으로만 남지 않음을 보여준다. 이 프로그램은 ‘N of 1’이라 불리는 맞춤형 치료법의 현장을 조명한다. 치료약도 없는 희귀질환의 벽 앞에서, 라온이의 가족은 하루하루의 시간이 멈추기를 바라며 살아간다. 그러나 세상 어딘가에서 비슷한 기적이 실제로 만들어진 적이 있다. 뇌의 손상으로 점점 기능을 잃어갔던 6살 소녀 밀라를 위해 개발된 ‘밀라센’ 치료제 사례는, 왜 한 사람만을 위한 새로운 도전을 멈추지 않아야 하는지를 말해준다. 누군가의 구원이었던 이 맞춤형 치료는, 지식과 경험을 축적해 더 많은 이들에게까지 전달될 수 있음을 증명한다. “단 한 명을 위한 치료의 기적”…‘뉴스토리’ K헬스 혁신 도전→미래 의학의 조건 비춘다 / SBS 혁신은 제도와 지원에서 시작된다. 미국은 DARPA의 도전적 연구 방식에서 영감을 얻어 ARPA-H라는 전담 연구조직을 세웠다. 우리나라 역시 지난해 ‘K-헬스미래추진단’의 신설로 의료의 난제를 풀고자 하는 담대한 발걸음을 떼기 시작했다. 피 한 방울로 암을 조기에 진단하고, 우주 공간에서 신약 개발에 나서는 등 미지의 길을 개척하는 과학자들과 의사들, 새로운 미래를 믿고 기다리는 가족들의 시간이 화면 위에 펼쳐진다. 단순한 성공 확률이 아니라, 1%의 희망에 모든 걸 건 사람들의 이야기는 ‘N of 1’이 곧 ‘N of more’가 될 수 있다는 믿음을 심는다. 나라와 제도, 그리고 기술의 협력 아래 실마리가 열릴 때 비로소 ‘기적’은 거대한 한 걸음이 된다. SBS ‘뉴스토리’는 11월 1일 토요일 오전 8시, 치열한 도전 끝에 현실로 다가오는 희망의 순간을 기록하며 의료의 미래에 대한 질문을 우리 앞에 놓는다.

“단 한 명을 위한 치료의 기적”…‘뉴스토리’ K헬스 혁신 도전→미래 의학의 조건 비춘다 #뉴스토리 #K헬스 #Nof1

Causal inference for N-of-1 trials The aim of personalized medicine is to tailor treatment decisions to individuals' characteristics. N-of-1 trials are within-person crossover trials that hold the promise of targeting individual-specif...

#statstab #412 Causal inference for N-of-1 trials

Thoughts: Only skimmed this, curious what the #causalinference ppl think of this.

#Nof1 #causalinference #ATE #effect #estimand #inference

arxiv.org/abs/2406.103...

#statstab #411 Dynamic structural equation modeling [Hamaker et al]

Thoughts: Has a great explanation for analysis N-of-1 studies.

#Nof1 #bayesian #sem #modelling #tutorial #bookchapter

www.statmodel.com/download/Ham...

#nof1 #breastcancer #physicalactivity #EMA

- 10/16 participants 📈 self-efficacy
- idiographic dynamic patterns identified
- significant self-efficacy 📈 could be independent of depressive or anxiety symptom

😎published in a diamond model journal😎

journals.shareok.org/singlecasejo...

TW: Painful facial expressions

These 4 trials show a basic pattern of my response to C-tactile touch. EEG, ECG, and more soon. See thread for hypotheses!

Also, please excuse the very scientific Q-tip. I've...misplaced my Von Frey monofilaments! 😂

#BuildInPublic #Neurophysiology #Biosignals #Nof1

The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience - PubMed We interpret the results as supporting the feasibility and usefulness of n-of-1 trials in clinical practice.

#statstab #395 The n-of-1 randomized controlled trial: clinical usefulness

Thoughts: Could RCTs comprised of 1 participant be useful? Maybe! And more so than large sample observational studies.

#Nof1 #RCTs #causalinference #research #methods #clinical

pubmed.ncbi.nlm.nih.gov/2297206/

A terminal window displays output from running a Node.js script (node build/scripts/demo.js) for a causal model used in the I-INSULA protocol. The causal model M is shown as a triple ⟨U, V, F⟩, where U is a set of external variables (like C-tactile, vestibular, thermal, and visual stimuli), V is a set of internal biosignal variables (like source-localized EEG and EMG), and F is a set of causal mechanisms represented as functions. A submodel Mx is also shown, where one function in F has been modified to return a constant value (e.g., 1) to simulate activity of an internal variable (in this example, posterior insular cortex activity) to test whether it is sufficient to causally explain downstream activity in the cingulate cortex or EMG muscle activity.

A screenshot of TypeScript code in a code editor, showing part of the StructuralCausalModel class implementation. The method toSubmodel takes a set of mechanism modifications (Fx), stores them in instance variables (currentF, currentFx), and performs causal mechanism overrides via doMechanismModifications(), replacing the function with a constant-returning one. The new submodel is then created in createSubmodel() and returned.

C-tactile touch (slow, gentle) is normally pleasant.

For me, it's painful (allodynia) and causes involuntary movements / vocalizations under certain conditions.

Hypothesis: C-tactile => #Insula => Cingulate => PAG => Motor

Here’s a partial #causal model to test!

#BuildInPublic #EEG #Nof1

Screenshot of a TypeScript class named StructuralCausalModel implementing Judea Pearl’s formalism of a structural causal model. The class defines private readonly fields U, V, and F for external (exogenous) variables, internal (endogenous) variables, and causal mechanisms, respectively. It includes a static Create method, a toTriple method, and supporting interfaces for typing the causal model components. The code structure reflects a modular, type-safe design for executable causal modeling.

I’ve been building these graphs to show likely neuroanatomical pathways of my unexplained condition.

Tonight, I started building the causal engine to move from unexplained to explained.

I'm becoming a falsifiable model, one mechanism at a time.

#Neuroscience #Causality #EEG #Nof1 #BuildInPublic

I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway

OSF

#statstab #329 Bayesian versus frequentist approaches in multilevel single-case designs: on power and type I error rate

Thoughts: An interesting project highlighting some benefits of #bayesian methods for #nof1 designs.

#stats #r #sced #mixedeffects

osf.io/k7b82/files/...

Small Sample Size Solutions | A Guide for Applied Researchers and Prac Researchers often have difficulties collecting enough data to test their hypotheses, either because target groups are small or hard to access, or because data

#statstab #319 Small Sample Size Solutions [book]

Thoughts: This should just be the default text for psychologists, as most research fits the "small sample" label.

#smallsample #book #guide #bayesian #permutation #sem #metaanalysis #nof1 #missingdata

doi.org/10.4324/9780...

The analysis of continuous data from n-of-1 trials using paired cycles: a simple tutorial - Trials N-of-1 trials are defined and the popular paired cycle design is introduced, together with an explanation as to how suitable sequences may be constructed.Various approaches to analysing such trials ar...

#statstab #311 The analysis of continuous data from n-of-1 trials using paired cycles: a simple tutorial

Thoughts: @stephensenn.bsky.social shows how to treat multiple #nof1 studies as a meta-analysis.

#sced #nof1 #metaanalysis #tutorial #clinical

trialsjournal.biomedcentral.com/articles/10....

10000% yes. #Dermatomyositis at 2 years old, in remission since 1972. But the havoc it wrecked has been super painful. And since survival rates were lower back then, I have never seen anyone (patient or doctor) who gets it #Nof1 or, frankly, seems to know what’s going on. And also pain scales suck.

Vacant ICN roles

Deadline approaching - 21st March.

Join the International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) Team! – Multiple volunteer opportunities available. More info here www.nof1sced.org/vacancies #nof1

Personality psychology is getting personal: Advancing the field through personalisation.

Pleased to see this paper just published. We explore the need for personalised research methods (including #Nof1 methods) in psychology. Traditional methods often fall short because they assume what works for the ‘average’ person works for everyone -rarely true! journals.sagepub.com/doi/10.1177/...

Beyond nomothetics and idiographics: Towards a systematization of personality research approaches - Le Vy Phan, Nick Modersitzki, Niclas Kuper, Nadin Beckmann, Malgosia Fajkowska, Mario Gollwitzer, Ka... Psychology is concerned with both general laws of psychological functioning and with the individual person. The debate surrounding nomothetics and idiographics ...

Just read this thought-provoking paper published in EJPP that explores the evolving debate between nomothetic & idiographic approaches in personality research. Was happy to see N-of-1 studies highlighted for their role in generating person-specific insights journals.sagepub.com/doi/abs/10.1... #nof1

The words used in #radiology are similar to that of #design and how our words, build 🌎

#RSNA24 #Nof1

Within the guidelines of ACR it even states that it may be appropriate to communicate rules directly to #patient

#RSNA24 #Nof1

Interesting, when asked the room if there are laws required to report results to #patient, majority of room said 🤷🏾‍♂️

Yet, if you’re a breast #radiologist it’s standard practice.

#RSNA24 #Nof1

The average hospital in the U.S. creates an average of 50 PB of data annually.

Yet, 90% of that data goes unused.

Missed opportunity for #patients & #physicians to deliver better care at the #Nof1

#RadSky #RSNA24

Road to #RSNA24

This will be the most calm all week. Excited to learn, observe, and connect with others wanting to make an impact on #healthcare

#RadSky #Nof1

HLTH 2024: The Moment N of 1 Medicine Arrived

bit.ly/3YGmLwo

#Nof1 #healthcare #AI

See you soon my friend. It’s going to be a busy and exciting week. Learning from others at the #Nof1 during #RSNA24

Discover thousands of collaborative articles on 2500+ skills Discover 100 collaborative articles on domains such as Marketing, Public Administration, and Healthcare. Our expertly curated collection combines AI-generated content with insights and advice from ind...

Evolution of Care: Solving Healthcare’s Supply Crisis Without Losing Our Soul

bit.ly/3Ot7xpC

#healthcare #Nof1 #ptexp

Small is beautiful: In defense of the small-N design - Psychonomic Bulletin & Review The dominant paradigm for inference in psychology is a null-hypothesis significance testing one. Recently, the foundations of this paradigm have been shaken by several notable replication failures. On...

#statstab #220 Small is beautiful: In defense of the small-N design

Thoughts: "high power and inferential validity of the small-N design, in contrast to the lower power and inferential indeterminacy of the large-N design"

#nof1 #sced #scd #smallsample

doi.org/10.3758/s134...

Pon #nof1 o #nof1ñ y no sale en los feeds de coches de colores 😂🤣