#ClinicalResearch #QualityImprovement #HealthcareInnovation #PatientEngagement #RandomizedTrials #TranslationalResearch

A clinician's guide for conducting randomized trials in individual patients - PubMed In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a partial guide and have not been or cannot be carried out for most clinical disorders. However, randomized controlled trials (RCTs) in individual pat …

#RandomizedTrials in individual patients – #Nof1 #RCTs – provide the highest certainty evidence of treatment impact in an individual. The epitome of best clinical practice. This article gives a step by step for setting up and running an N of 1 trial.

pubmed.ncbi.nlm.nih.gov/3409138/

#WordsOfToday "Would trying to solve the puzzle of designing a study to solve the puzzle of whether people solving puzzles is good for the brain, help solve the puzzle?" Oko Dus, 2020

#Puzzle #Sudoku #Crossword
#RandomizedTrials #RCT
#WhoseTrialIsItAnyway?
#QuotesDaily

Ahoy! You might also be interested in reading the piece Dave Sackett wrote for me about why he became a clinician trialist. It's available free here: www.jameslindlibrary.org/articles/why...
#RandomizedTrials #DaveSackett #EBM

Why did I become a clinician-trialist? - The James Lind Library The seeds of iconoclasm In 1956 I went to the University of Illinois College of Medicine to be taught how to become a physician. Despite the College’s well-deserved reputation, a ...

Ahoy! You might also be interested in reading the piece Dave Sackett wrote for me about why he became a clinician trialist. It's available free here: www.jameslindlibrary.org/articles/why...
#RandomizedTrials #DaveSackett #EBM

Why randomized controlled trials fail but needn't: 1. Failure to gain "coal-face" commitment and to use the uncertainty principle From the undersideMy pager went off as I was half-dozing, half-reading the newspaper. Yuri Gagarin, born the same year as me, had just become the first man to orbit the earth; Nelson Mandela, not yet ...

This week's reading and learning: Dave Sackett's essay from 25 years ago on why not gaining "coal-face" commitment and not using the uncertainty principle can lead to the failure of randomised trials
www.cmaj.ca/content/162/... #ReadAboutTrials
#RCT #EBHC #EBM #RandomizedTrials
@cmaj.ca

Patterns of pre-registration and publication of trials in Cochrane systematic reviews of interventions It is widely recognised that selective reporting clinical trial results based on their outcomes, in the forms of publication bias, outcome reporting bias, or p-hacking, has detrimental effects on the ...

#CochraneDaily Just published! Study of 50 Cochrane reviews found that only one quarter (109 of 423) of the included trials which examined the primary outcome had been pre-registered www.jclinepi.com/article/S089...
#Cochrane
#RCT #RandomizedTrials
@jclinepi.bsky.social

CONSORT 2025 statement: updated guideline for reporting randomized trials.

www.nature.com/articles/s41...

@natmedicine.bsky.social
#CardioSky #MedSky #RandomizedTrials

Trends and influences in women authorship in randomised controlled trials in rheumatology: a comprehensive analysis of all published RCTs from 2009 to 2023 Objectives We examined the evolution and influencing factors of women’s authorship in randomised controlled trials (RCTs) published in rheumatology. Methods We analysed all RCTs published in rheumato...

Women’s authorship in RCTs: how much, how is it evolving?

We analyzed the gender of authors in all #randomizedtrials in #rheumatology since 2009.

Short answer: Not great, and not improving.

Just published in RMD Open: doi.org/10.1136/rmdo...

Some details below ⬇️ 1/5
#Metaresearch #EpiSky

Prospective registration of trials: where we are, why, and how we could get better Transparent trial conduct requires prospective registration of a randomized controlled clinical trial (RCT) before the enrollment of the first participant. We aimed to (1) estimate the proportion of R...

Do people register their #randomizedtrials before starting it ?
We studied more than 1000 RCT in #rheumatology to answer this question, to see how it evolved in time and how it varied between RCTs⬇️

Just published in @jclinepi.bsky.social :
jclinepi.com/article/S089...

#Metaresearch #EpiSky

In Chapter 10 of "Causal Inference: What If", we describe arguments for adjustment in randomized trials and refute some fallacies used to advise against adjustment.
www.hsph.harvard.edu/miguel-herna...

A practical challenge is how to incorporate adjustment into the design of #randomizedtrials.

The necessity of analyzing parallel group randomized studies by actually comparing the parallel groups needs to be hammered home. I’m so glad to see this letter @statsepi.bsky.social #statistics #rct #randomizedtrials