Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
Happy to see our work on SLCO2A1 with @smlea.bsky.social, Nakanishi and Newstead labs out now. Important insight into how prostaglandin and many drugs are transported. Hats off to @weitse-hsu.bsky.social for computational work!
@oxfordbiochemistry.bsky.social
www.nature.com/articles/s41...
Researchers standing in front of whiteboard with scientific information
WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field.
Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social
www.wehi.edu.au/news/new-enz...
Introducing our new blood-stage malaria vaccine immunogen based on the essential invasion protein PfCyRPA. By understanding where on PfCyRPA the best antibodies bind, we used structure guided design to generate PfCyRPA-EM, which contains only the epitopes of the best antibodies.
🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41...
RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10
#RNA #IDR #RBP
🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it?
Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear.
Our new paper in Cell Death & Differentiation uncovers one. 🧵👇
nature.com/articles/s41...
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗
@ibc2-gu.bsky.social @goetheuni.bsky.social
We have an opening for a research support officer. Come and join us! Please share.
SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR
