Proper organelle regulation during mitosis is a must, but how do membrane-less condensates like PML bodies behave during cell division? In work led by Eric Aird, we found the balance of speckled proteins SP110 & SP100 to be the key. doi.org/10.1038/s415...

Our Simon Lam developed the user-friendly web portal to freely share this map of interactions, spidrweb.org, making this a global resource for all, to help identify therapeutic targets for cancer and other DDR-related diseases.

Comprehensive interrogation of synthetic lethality in the DNA damage response Nature - Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in...

Thrilled to see this “veritable tour de force” led by John_C_Fielden from Jacob Corn lab out @nature.com, rdcu.be/ehd4E. This @erc.europa.eu funded project uses #CRISPRi to systematically scan 548 DDR genes for synthetic lethal interactions, ~150,000 pairwise combinations!

Exciting opportunity for a suitably qualified individual to join us, www.jobs.cam.ac.uk/job/50998/

Exciting opportunity for @astarsg.bsky.social student @cggoh.bsky.social to exchange new ideas on #CRISPR and #BaseEditing with @spjacksongroup.bsky.social alumnus Dan Durocher @durocher1.bsky.social, with postdoc Dr Simon Lam at #CRISPR25 @eventswcs.bsky.social

We also acknowledge the partner publication from @marcelvanvugt.bsky.social‬ and @durocher1.bsky.social, www.biorxiv.org/content/10.1...

Excited to share our latest preprint. Work led by PhD student @jordancjwilson.bsky.social with @profmarciniak.bsky.social, @villungerlab.bsky.social & our @erc.europa.eu partners @jcornlab.bsky.social & @loizoulab.bsky.social, that sheds light on the action of WEE1 inhibitors. bit.ly/4bDpxZl