In The #Endocrinologist, @safwaanadam.bsky.social and @akheelsyed.bsky.social, describe the various biological effects of obesity in worsening the health of the heart muscle and blood vessels, and how weight loss treatments have benefits for cardiovascular health too. 🫀

Read more👉 shorturl.at/KML5v

Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Request PDF Request PDF | Prioritizing Quality of Life in the management of hyperthyroidism—An expert clinical perspective | Hyperthyroidism adversely affects quality of life (QoL), encompassing physical, mental ...

Thyroid overactivity worsens patients' quality of life (QoL). After treatment, QoL is not completely restored for many patients. We discuss reasons, and new approaches to address long-term effects on QoL.
@ncaresearchnhs.bsky.social
@endoconnect.bsky.social

www.researchgate.net/publication/...

A young woman with Kallmann syndrome and acute neurologic symptoms Diagnoses considered on initial presentation included conditions that present with stroke-like symptoms such as seizure, hemiplegic migraine, transient ischemic attack, and brain tumor.

What's the diagnosis? Be warned: Not everything is as it seems!
Ali, @adhithyasankar.bsky.social, et al. @ncaresearchnhs.bsky.social

www.ccjm.org/content/93/1...

Adult Adrenal Insufficiency To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

Time for wider adoption of salivary cortisone in endocrinology?
@akheelsyed.bsky.social @addisonsdisease.bsky.social @socendocrinology.bsky.social #AdrenalInsufficiency #Endocrinology #SalivaryCortisone

jamanetwork.com/journals/jam...

Adult Adrenal Insufficiency To the Editor In the recent Review on adrenal insufficiency in adults,1 the authors discussed noninvasive diagnostic approaches such as salivary cortisol sampling, which is widely used in the assessme...

Adult Adrenal Insufficiency url: jamanetwork.com/journals/jam...
The role and value of salivary Cortisone test in investigation of Adrenal Insufficiency in adults

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes | NEJM Orforglipron is a small-molecule, nonpeptide glucagon-like peptide-1 (GLP-1) receptor agonist in clinical development for type 2 diabetes and weight management. Additional data on the efficacy and ...

www.nejm.org/doi/full/10....

Heterogeneity in response to GLP-1 receptor agonists in type 2 diabetes in real-world clinical practice: insights from the DPV register – an IMI-SOPHIA study - Diabetologia Aims/hypothesis Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a cornerstone in type 2 diabetes management. In this study we evaluated heterogeneity in body weight and glycaemic responses t...

Does every person with type 2 diabetes respond the same way to GLP-1 receptor agonists? Recent clinical data suggest otherwise. #GLP1 #diabetes link.springer.com/article/10.1... 🔓

Adrenocortical carcinoma: a practical guide for clinicians Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous but frequently aggress...

#Adrenocortical #carcinoma is a rare malignancy, in contrast to benign #adrenal tumours, which are among the most common human neoplasias with a prevalence of greater than 3% in adults older than 50 years www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #OncSky

GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review - International Journal of Obesity International Journal of Obesity - GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review

www.nature.com/articles/s41...

Approach to the patient: Low testosterone concentrations in men with obesity Abstract. Pathologic hypogonadism occurs when serum testosterone is significantly and persistently reduced by irreversible organic (structural, genetic) di

How to think about evaluation of low testosterone levels, SHBG, clinical symptoms and possible benefits vs. real risks of treatment in the context of #obesity academic.oup.com/jcem/advance...

#Finerenone: CV & renal protection across all #T2D therapies❗️

🔹 Pooled analysis: 15,365 pts w/ T2D + CKD or CV

🔸 Consistent benefit on 💔☠️, 🏥💔& kidney outcomes

🔹 ⤴️K+ ⤵️ with SGLT2i use

🔸 Benefit independent of SGLT2i/GLP-1 use

👉 Supports finerenone as a 🎯 in high-risk #T2D❗️

🔗 ggdocs.co/tx2a5r

Delphi Panel consensus on recommendations for thromboprophylaxis of venous thromboembolism in endogenous Cushing's syndrome: a Position Statement AbstractObjective. To establish recommendations for thromboprophylaxis in patients with endogenous Cushing's syndrome (CS), addressing the elevated risk of

academic.oup.com/ejendo/advan...

Pleased to share our case report!

RAI is known to worsen TED in Graves’ disease, but what about nodular thyroid disease?

Assessment of TPO antibody, and not just TRAb prior to RAI may be informative in guiding decision-making around steroid prophylaxis.

casereports.bmj.com/content/18/2...

Obesity Management for Patients with Coronary Artery Disease and Heart Failure

Obesity is the third most important predictor of heart disease. We discuss pathophysiology and management including roles of anti-obesity medications and bariatric surgery.
@ncaresearchnhs.bsky.social

www.sciencedirect.com/science/arti...

Actual weight loss trajectories after bariatric surgery compared with the SOPHIA prediction tool: An observational comparison study - PubMed The SOPHIA study tool provides accurate postoperative weight forecasts for some subgroups of patients, but its precision diminishes with time. This study reiterates the necessity for better personaliz...

Accurate prediction of long-term postoperative weight loss is important for advising patients undergoing bariatric surgery.
@adhithyasankar.bsky.social et al.
pubmed.ncbi.nlm.nih.gov/39887840/

@ncaresearchnhs.bsky.social

@akheelsyed.bsky.social

How well can we predict weight loss after bariatric surgery?

Our study assessed the SOPHIA weight prediction tool in our patient population.

dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/...

Peri-operative management of GLP-1 RAs & SGLT2 inhibitors❗️

🔹 New 🇬🇧 consensus: GLP-1 RAs can continue, but risks of aspiration must be assessed.

🔸SGLT2i should be stopped 1 day pre-op to avoid euglycemic DKA.

❗️shared decision-making & tailored approaches to optimise safety.

🔗 ggdocs.co/4r995z

🧵 Cancer Cachexia and the Brain Stem (a thread)

In NEJM, Groarke et al. report the results of a phase 2 clinical trial of ponsegromab therapy for cancer cachexia in patients with elevated humoral levels of growth differentiation factor 15 (GDF-15). nej.md/3XE645a 1/10

#MedSky #ScienceSky

Cardiovascular risk and obesity impact loss of grey matter volume earlier in males than females Background It remains imperative to discover the time course that cardiovascular risk factors influence neurodegeneration in males and females and decipher whether the apolipoprotein (APOE) genotype m...

jnnp.bmj.com/content/earl...

The real reason men get belly fat (and how to get rid of it) Research suggests it’s more dangerous to be an overweight man than woman. Here’s why – and what you can do about it

www.telegraph.co.uk/health-fitne...

Eye-opening patient story regarding ACC and mitotane

Genetic basis of early onset and progression of type 2 diabetes in South Asians Nature Medicine - In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key...

It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵

Presentation and management of patients with adrenal masses: a large tertiary centre experience AbstractBackground. Adrenal masses are found in up to 5%-7% of adults. The 2016 European guidelines on the management of adrenal incidentalomas have standa

Presentation and management of patients with adrenal masses: a large tertiary centre experience by Onnicha Suntornlohanakul et al @Bham_AT doi.org/10.1093/ejen... #adrenal #phaeochromocytoma #ACC

How the #brain talks to the #gut and vice versa!
🧪🧠💩

Check out the great primer on gut-brain communication and #interoception by @amberalhadeff.bsky.social and Nilay Yapici

👇👇👇
www.cell.com/current-biol...

Correction Rates and Clinical Outcomes in Hospitalized Adults With Severe Hyponatremia This systematic review and meta-analysis evaluates the association of sodium correction rates with mortality among hospitalized adults with severe hyponatremia.

Honey, stop what you're doing, new hyponatremia research just dropped!

What's it say?

It looks like slow correction is associated with worse outcomes, like death and length of stay!

Was it just a small study?

No, it was a meta-analysis of almost 12,000 patients!

jamanetwork.com/journals/jam...

Expert statement on Diagnosis & Mx of peripheral neuropathy in #diabetes & pre-diabetes (Gulf region)

🔸suggest routine screening (patient questionnaire & clinical assessment)

🔹Universal B12 Rx

🔸Check B 1&6 levels

🔹Use of CGM

🔸Use of GLP1

🔗 link.springer.com/article/10.1...