Here we discovered and leveraged the regenerative properties of ribonucleotide production via the Pentose Phosphate Pathway to boost axonal regeneration in the central nervous system in vivo, and found that ribose treatment alone can be used to trigger axonal regrowth 💪🏽✨

A glycolytic shunt via the pentose phosphate pathway is a metabolic checkpoint for nervous system sensory homeostasis and axonal regeneration The pentose phosphate pathway plays a dual role in enabling homeostatic and regenerative adaptations to environmental stimuli and injuries and can be leveraged to promote regeneration and recovery aft...

Very grateful to start the year by sharing a paper that holds a special place in my heart. I started and led this project during my years at Imperial, and it was brilliantly continued by Yayue, Di Giovanni’s lab and collaborators afterwards until seeing the light at Cell
www.cell.com/cell/fulltex...

Great two days in York with the MRC National Mouse Genetics Network. Always a pleasure to be invited to share MitoCluster's work, thank you!

@mrcmousenetwork.bsky.social @jellevda.bsky.social @lauragreaves.bsky.social @robpitceathly.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

Thank you!☺️

Congratulations to @lucialugut.bsky.social who passed her PhD with flying colours last week; and with no thesis corrections ☺️🎓👏

This is amazing news!! @camneurodept.bsky.social @mrc-mbu.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @mito-news.bsky.social

Thanks Michal & team!

On Monday, I was beyond honoured to receive a CSAR award for my PhD project - I’m truly grateful to the committee for the recognition

Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...

Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research

We led a workshop on making complex science clear – because involving patients is key to success

#mitochondrialdisease #mitoresearch #patientvoice #raredisease

Engineering mtDNA deletions by reconstituting end joining in human mitochondria Combined expression of a mitochondrially targeted endonuclease and end-joining machinery enables formation of mtDNA deletions with a broad range of heteroplasmy.

Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...

Hypothalamic deep brain stimulation augments walking after spinal cord injury - Nature Medicine Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recover...

Hypothalamic deep brain stimulation augments walking after spinal cord injury. Yes, this is wild. I wonder if there is anything the hypothalamus can't do. #neuroscience 🩺

Cho et al., Nat Med
www.nature.com/articles/s41...

Macrophages excite muscle spindles with glutamate to bolster locomotion - Nature A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle s...

Check this out!! Awesome discovery by the labs of Carmelo Bellardita in Copenhagen Univ and Simone di Giovanni in London on the physiological role of macrophages in muscle spindles on proprioceptor afferents - implication in sensorimotor control of movement
www.nature.com/articles/s41....

Proud to announce the publication of our latest paper!

Huge thanks to all our collaborators for making this work possible. #Science #Mitochondria #Research #MitochondrialDisease #RareDiseases

www.embopress.org/doi/full/10....