Doing all this at single-cell resolution allowed high-throughput, and was essential to capture the mosaic nature of mtDNA. Hopefully #MitoPerturb-Seq will lead to discovery of novel mtDNA maintenance and quality control genes, and solve cell-type specific vulnerabilities to #mitochondrialdisease.

Interested in Pre-clinical Mitochondrial Disease Models?

MRC MitoCluster is delivering a session this May at Queen Square Advances in Mitochondrial Medicine 2026. Register now to join!

#MitochondrialDisease #MitochondrialMedicine #mtDNA #GeneticEngineering #PreclinicalResearch #RareDisease

✨ We raised £100,000! ✨

Our Burlesque Ball was a night of glamour, sparkle and real impact, helping drive mitochondrial research forward.

Thank you to everyone who made it possible 💫

Read more 👇
https://ow.ly/ivEt50YACsF

#MitochondrialDisease #Fundraising #Hope

“Promotional graphic for Tisento Therapeutics. On the left, pink text reads ‘Let’s Connect at #Euromit2026!’. Below, white text states that the company is on a mission to deliver medicines that address what matters most, starting with the rare mitochondrial disease MELAS. On the right, the Tisento Therapeutics logo appears, featuring a stylized mitochondria-like symbol. The background shows a night sky with green and purple aurora borealis. At the bottom left, the website ‘www.tisentotx.com’ is written in green.

@tisentotx.bsky.social is proud to support #euromit2026 as a Silver Sponsor! Our clinical program in the rare #MitochondrialDisease #MELAS is evaluating zagociguat’s effect on symptoms that matter most to patients—including fatigue and cognitive dysfunction. Visit our booth at #Euromit2026#WeHearYou

Flyer reads: RAISING RHIA: A MOTHER'S FIGHT FOR A JOYFUL LIFE, TERENA SCOTT

My friend Terena has launched her new book!
This is a #Memoir on caring for her daughter, who has a #MitochondrialDisease.
Simple, direct, powerful. Highly recommend.

terenascott.com

#CareGivingLife #SpoonieSky

Lizzy's spent years, and thousands of pounds, travelling the world in search of answers to daughter Mathilde’s health problems.

Today, that journey's come full circle thanks to our Precision Diagnostics project.

Read their story:
https://ow.ly/TxgM50YqgK9

#MitochondrialDisease

Rare Disease Day – 28 February 2026
Let’s unite to improve diagnosis and understanding of mitochondrial disease.

These rare conditions can affect any organ, at any age, impacting at least 1 in 4,000 people. Greater awareness and research are vital.

#RareDiseaseDay #MitochondrialDisease

Ahead of #RareDiseaseDay, please join us to educate and increase awareness
about rare mitochondrial diseases

Show you care and share, let's shout about mitochondrial disease and raise awareness around it!🩷 #MitochondrialDisease #Awareness

There are 6,000+ rare diseases—and expertise and information are often scarce. In health systems designed for common diseases, rare diseases often face inequities. download2.rarediseaseday.org/2025/campaig... #RareDiseaseDay #HealthEquity #MitochondrialDisease #MELAS #Biosky

If I had the means to evacuate to The #UK, or The #EU, seeking #assylum, I would gladly do so. Unfortunately being #disabled with #MitochondrialDisease & unable to work with no reliable source of income, I have nothing to offer those countries.
I never thought I'd see this day.
#RIP USA 1776-2025

Early Bird extended to Feb 27, 2026! Final chance to get the preferential rate.

🔗Register now: www.euromit2026.eu/registration/

EUROMIT 2026 – May 31–June 4, Angers - France

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social

Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species - Nature Metabolism Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.

Most recent collection of papers on #Mitochondria in #Health and #Disease!
#week7 #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social
www.nature.com/articles/s42...

UCB is a Diamond Partner at #Euromit2026 💎

We look forward to discussing the latest advancements in thymidine kinase 2 deficiency (TK2d) with the mitochondrial community and sharing our commitment to optimize TK2d management.

Meet us at Euromit2026! 🤝

#mitochondrialdisease #TK2d #raredisease #UCB

Promotional image announcing the upcoming deadline for the Early Bird rate for EUROMIT 2026. At the top, the text reads “Take advantage before February 17, 2026!”. In the center, two tilted green shapes display the words “Early Bird” and “Rate”. The background features green, mitochondria‑like patterns on a black backdrop. At the bottom, a green band contains the text “EUROMIT 2026

Only a few days left to get the Early Bird rate!

Early Bird registration for EUROMIT 2026 ends on 17 February 2026

👉 Registration : lnkd.in/ecsTM5Gr

👉 Submit your abstract : lnkd.in/ejCS3e4t

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social

The #MELAS Externally Led Patient-Focused Drug Development meeting is today! Hosted by #MitoAction, the event invites those affected by MELAS to share their experiences and be part of shaping #MitochondrialDisease care and treatment. www.mitoaction.org/join-the-cau... #Biosky

Mitochondrial superoxide regulates nuclear envelope integrity and ageing via redox-mediated lipid metabolism - Nature Metabolism Mitochondrial superoxide production is shown to preserve nuclear envelope integrity by controlling lipid peroxidation, with impact on nuclear and organismal ageing in C. elegans.

A new collection of papers on #Mitochondria in #Health and #Disease! #MitochondrialDisease 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mt superoxide regulates nuclear integrity and ageing via lipid metab

www.nature.com/articles/s42...

Dr Liisa Laakso | A Ray of Hope for Mitochondrial Disease - SciTube MELAS is one of a number of rare genetic conditions in which a person’s cells struggle to make enough energy. As a result, people with MELAS often face extreme fatigue, muscle weakness, strokes, and a...

A ray of hope for mitochondrial disease research with Dr Liisa Laakso, exciting progress and insights that could change lives.
scitube.io/dr-liisa-laa...
#MitochondrialDisease #ScienceCommunication doi.org/10.3390/jcm14062047

ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination - Nature Communications For proper mitochondrial inheritance, paternal sperm mitochondria must be eliminated. Here, authors identify ALKB-1 mediated tRNA demethylation as essential for this clearance in Caenorhabditis elegan...

A new collection of papers from #week5 on Mitochondria in Health & Disease! #MitochondrialDisease
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Among highlights
www.nature.com/articles/s41...

Book Early and Maximize Your Benefits

📢 New update on our website!
👉Don't forget : early‑bird rates are available until Februray, 17 !!
👉 : www.euromit2026.eu/article/book...

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social

We believe meaningful innovation starts with listening. That’s why we’re conducting an interview study with adolescents (12-17 years) who are living with #MELAS, a rare #MitochondrialDisease. The final group is enrolling now! www.tisentotx.com/s/Tisento-Ad... #biosky

Brotherly love

My favorite thing swimming and chocolate

Just weeks before he passed.

Thinking of you on what would have been your 16th birthday. 🎂 💚
Perfect analogy is Loosing someone you love is like having your pockets full of rocks the weight never goes away you just learn how to carry it. 😭😢💚
#mitochondrialdisease

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...

Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

www.nature.com/articles/s42...

MitoAction Mito Town Meeting | Friday, January 16 | Noon to 2:45pm ET Hear from Jennifer Chickering, our Vice President of Program Leadership, around 2pm!

What will 2026 bring for the #MitochondrialDisease community? Join the @MitoAction town meeting on Friday to hear insights from advocates, clinicians, and industry leaders, including our VP of Program Leadership, Jennifer Chickering. Register here: www.mitoaction.org/resources/20... #Biosky #MELAS

Mitochondrial control of fuel switching via carnitine biosynthesis Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosynthe...

Last 2 weeks of research papers relevant to #MitochondrialDisease!
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mitochondrial control of fuel switching via carnitine biosynthesis
www.science.org/doi/10.1126/...

Call for Sponsorship

📢 Call for Sponsorship – Euromit 2026!
Become a sponsor and link your brand to one of the most awaited events in mitochondrial disease research. 👉 www.euromit2026.eu/article/call...

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria

@chuangers.bsky.social @univangers.bsky.social

We’ve completed enrollment in PRIZM, our global Phase 2b study evaluating our investigational medicine’s impact on fatigue and cognitive function in MELAS – a #RareDisease that currently has no approved treatments. #MitochondrialDisease #Biosky www.tisentotx.com/news/tisento...

End-of-year selection of papers on #MitochondrialDisease! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mitoscientists.bsky.social
Have a great 2026! ✨

Asked me a year ago if I would be a published Author, I'd have said you're nuts. #Author #books #lgbtqia #writer #OnTheSpectrum #neurodivergent #disabled #MitochondrialDisease

This year was filled with momentum and meaningful moments as we worked alongside the #MitochondrialDisease community to amplify MELAS voices and advance our mission to deliver medicines that can address what matters most. Take a look at our #2025Wrapped. #WeHearYou #BioSky

Call for Abstracts – Euromit2026

📢 New update on our website!

The Call for Abstracts for Euromit 2026 is open.

👉 Call for Abstracts : www.euromit2026.eu/article/call...

#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria
@chuangers.bsky.social
@univangers.bsky.social