Over the course of two years (1937–1939), #experiment after experiment confirmed
the #vesicular #disintegration of #swelling #matter and the #organization of #bacteria and #cells from the #bions.
Wilhelm Reich
The #Cancer Biopathy

#suppressed #orgone #biophysics #history
#biosky #psychsky #oncology

"The substances were mixed and boiled, and my colleagues detected cell-like moving structures immediately after boiling."

Wilhelm Reich to Roger du Teil
12 December 1936
Beyond Psychology p.81
Edited by Mary Boyd Higgins

#orgone #biophysics #history
#biosky #medsky #psychsky
#dystopian #war #crime

Natural protein sequences represent only a fraction of what’s theoretically possible The limitations imposed by evolution have implications for AI tools trained on existing sequences and de novo protein design

Natural protein sequences represent only a fraction of what's theoretically possible | #chemsky #biosky #proteomics

Been working on some of my own figure making and made this little html tool to pull from InterPro API and enhance the sunburst plots. #evolution #taxonomy #biosky #genome #science #protein
www.schiracha.com/taxonomysunb...

I'll be at BIO this June. Relatedly, it's so hard to imagine traveling to San Diego just to hang out in the convention center. Who wants to meet with me at the Point Loma tide pools? #biosky

AlphaFold Database expands with millions of predicted protein complexes A new collaboration between EMBL's European Bioinformatics Institute (EMBL-EBI), Google DeepMind, NVIDIA, and Seoul National University has made millions of AI-predicted protein complex structures ope...

AlphaFold Database expands with millions of predicted protein complexes | #AI #chemsky #biosky

Semi-Social: Biruté Galdikas and the Complicated Simplicity of the Bornean Orangutan. By 1971, when a 24 year old anthropology student by the name of Biruté Galdikas (1946-2026) set foot in the wilds of Borneo to study the largely unknown behavior and social structure of wild orangutan...

So sorry to hear of the death of Biruté Galdikas today at the age of 79. A visionary who brought the full extent of her observational genius to a species that had been largely ignored by other researchers, she will always be remembered.

tinyurl.com/yc8hfhkc

#WomenInSTEM #WHM #BioSky #HistSci 🦧

On FDA, Q's re Commish's National Priority Vouchers by FDA policy expert K. Trzeciak (ex FDA). *Will FDA issue guidance 2 clarify product selection criteria, sponsor expectations & review timelines. *Will FDA publish minutes from CNPV Council meetings www.linkedin.com/posts/kimber... #medsky #biosky

Clinical chemist Greta Hammarsten was born 130 years ago today. An expert in chemical analysis of kidney stones and blood diseases, she authored some 80 papers and the book Kliniska Laborationsmetoder, which was the standard text throughout the 1940s and 50s.

#WomenInSTEM #WHM #ChemSky #BioSky 🧪

The biggest limitation in DNA synthesis isn’t cost. It’s:
• Sequence rejection
• Unpredictable timelines

🧪 Accessing complex DNA is only half the problem.
Getting it when you expect it is what keeps science moving.

📑 Read the Tech Note here: hubs.li/Q047n2hW0

#BIOsky

Shanghai start-up launches to develop trispecific antibodies Excalipoint Therapeutics has raised $68.7 million

A new start-up is launching out of Shanghai with $68.7 million and a plan to tackle cancer and autoimmune diseases with T-cell-engaging antibodies.

cen.acs.org/pharmaceutic...

@cenmag.bsky.social #chemsky #biosky

Wishing a happy 75th birthday to viral geneticist Handanahal Subbarao Savithri, who has uncovered the assembly mechanism processes of several viruses unique to India, and used that knowledge to develop virus-resistant plants, including leaf curl resistant cotton.

#WomenInSTEM #WHM #BioSky 🧪🌱

It’s #BrainAwarenessWeek! Many #MitochondrialDiseases can have negative implications for brain health. That’s because the brain requires a massive amount of energy, which can only be sufficiently produced when mitochondria are functioning well. #UMDF #Biosky

Wishing a happy 77th birthday to Russian neuroscientist Svetlana Dambinova, whose research in the 1990s and 2000s established the role that glutamate receptors play in different forms of brain injury and disease.

#WomenInSTEM #WHM #NeuroSky #MedSky #BioSky 🧪

Genetically modified foods and human health: a comprehensive review and cross-national time-trend analysis GMOs have remained at the center of scientific and societal debate since their regulatory authorization and subsequent market introduction in the 1990 s. This review synthesizes epidemiological evi...

"Current evidence does not support consistent causal links between GMO consumption and cancer, reproductive toxicity, allergies, or other chronic diseases."

GMOs 1000 : FUD 0

#biosky #biosecurity
www.tandfonline.com/doi/full/10....

Investigational Oral Biologic Achieves 100% C difficile Clinical Cure in Preliminary Cohort Summary of Contagion Live coverage: Lumen’s LMN-201 achieved 100% initial clinical cure in the RePreve sentinel cohort. Part B is now recruiting.

If a similar bacterial memory degradation mechanism exists in humans, then @lumenbio.bsky.social could use the same approach it does for its successful C. difficile therapy: a pill that specifically targets the offending bug "achieving a 100% clinical cure".
#biosky
www.lumen.bio/news/2025/04...

to read #BioSky

Learnings from #RareDisease #ClinicalDevelopment are shaping the future of medicine– from sharpened trial design discipline and innovation to deepened collaborations with patients, families, and other stakeholders around the world. #WeHearYou #Biosky
www.the-scientist.com/what-rare-di...

#ScienceSky #BioSky 🧪

All together now, "Unfavorable does not mean unstable."
Thank you. That is all
#biosky

"I think that there’s a lack of really trusting that this pathway that’s commercially viable for individualized medicine is really going to open up. If investors don’t believe in it, there are no companies in this space. The companies won’t last." Julia Vitarello, patient advocate and founder, EveryONE Medicines

The FDA recently described a new regulatory framework that would let personalized medicines with a “plausible mechanism” of action bypass randomized clinical trials.

But recent decisions about rare disease drug applications raise doubts about what the pathway means for patients.

#chemsky #biosky

CEO Ken Drazan will join a panel tomorrow, March 4, 3:30-4:30pm, at #PMWC26 on Gene Editing & Synthetic Biology for Therapy.

More: https://bit.ly/40DVqfx #Biotech #DrugDevelopment #biosky

Today is #RareDiseaseDay. We stand with the 300 million people globally who live with a rare disease, including those with rare #MitochondrialDiseases like #MELAS. Read stories of #RareDisease heroes: www.rarediseaseday.org/heroes/ #Biosky

The #cow gags it up for a
chew,
To grind every morsel to goo.
The #rabbit, instead,
Finds #nutrients spread,
In droppings it eats as if new.

#vss365 #limerick #animals #poetry
#coprophagy & #ruminant #regurgitation
#digestion #nutrition #copremesis
#biosky #biochemistry #gastrology #gastrosky
🔬 🧪 ⚗️

Small Molecule Restores Itaconate Sensitivity in Salmonella enterica: A Potential New Approach to Treating Bacterial Infections Become more sensitive: Although new antibiotics and resistance inhibitors provide temporary solutions to resistance, they are bound to become obsolete. In this work, we propose a new approach, coined...

One decade ago: the Auclair lab first examined small molecules to resensitize bacteria to macrophages. #chemsky #biosky

doi.org/10.1002/cbic...

Assessing Boltz-2 Performance for the Binding Classification of Docking Hits The recently released Boltz-2 cofolding model is generating high expectations by enabling both protein–ligand structure and binding affinity predictions. When applied to a recently described and chall...

#compchem #compchemsky #biosky
Good read: Assessing Boltz-2 Performance for the Binding Classification of Docking Hits pubs.acs.org/doi/10.1021/...

The course focuses on interpreting genomic data using virulence profiling and subtyping approaches, including MLST and cgMLST, in a public health context.

#IDsky #EpiSky #MedSky #BioSky #PublicHealth #Training #ECDC #Microbiology #Bioinformatics #Epidemiology

There are 6,000+ rare diseases—and expertise and information are often scarce. In health systems designed for common diseases, rare diseases often face inequities. download2.rarediseaseday.org/2025/campaig... #RareDiseaseDay #HealthEquity #MitochondrialDisease #MELAS #Biosky

Of particular relevance in the context of all the recent authoritative reports claiming LLMs can help novices develop and build threats.
#biosky

Taking the Wheel: Jennifer Doudna, Emmanuelle Charpentier, and the CRISPR-Cas9 Revolution in Gene Editing. Over the course of the last two decades, humanity has taken its first quiet steps from being the blind victims of genetic-molecular chance towards becoming purposeful actors in our biological fates.  ...

Wishing a happy 62nd birthday to CRISPR-Cas9 co-originator and 2020 Nobel laureate Jennifer Doudna, whose simple but effective gene editing technology harnesses ancient bacterial defense systems to make micro-targeted changes to genetic structures.

tinyurl.com/2wr28ny8

#WomenInSTEM #BioSky 🧬🧪