Hi all fans of #smart #microscopy,
we from @zeiss-microscopy.bsky.social have just published a new application note: "Study Mitotic Progression with Guided Acquisition – Rare Event Detection"
go2.zeiss.com/ODk2LVhNUy03...
For more details: forum.image.sc/t/applicatio...
Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/...
#Cytoskeleton
First paper as first & corresponding author, out in PLOS Computational Biology! 🎉
napariTFM brings traction force & monolayer stress microscopy into napari, accessible via GUI; open-source, validated and no coding required. 😉
Check it out 👇
True 😂😂 but is that how we feel? We could be so much more POLARIZING 🤩
Congrats and thanks to all poster coauthors @leonerossetti.bsky.social @icfortunato.bsky.social @ricardalert.bsky.social @xaviertrepat.bsky.social -- nothing can stop us!
Stoked to announce that I received a poster award! 🔥😍
Many thanks to the #25EngLife organizers for the amazing meeting!
Keep an eye on the upcoming tissue force (tension) sensors 🔥🔥
from @baldaufsci.bsky.social
My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...
📢Conference alert📢
Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.
engineering-life-dresden.de
Great success for Dresden and Saxony!
Physics of Life is one of the excellence clusters
@poldresden.bsky.social
Positional memory has implications for bioengineering. Transplanting salamander cells in a way that alters their spatial organisation changes signalling topology and results in predictable (but amazing) phenotypes such as too many fingers - or even extra limbs!
🧵3/14
1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”.
#cellbio #devbio #cellmigration
Cartoon of techniques to apply one-dimensional, in-plane or volumetric cell compression in vitro.
In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...
google search: how many r’s are in “strawberry pie” ai overview: there are 4 r’s in the phrase “strawberry pie”: - S: trrawbrry pie
all of human knowledge at my fingertips
We're so back
Will visit it when I am in Dresden on April 16!
Prague, 23 November 1911 Highly esteemed Mrs. Curie, Do not laugh at me for writing you without having anything sensible to say. But I am so enraged by the base manner in which the public is presently daring to concern itself with you!? that I absolutely must give vent to this feeling. However, I am convinced that you consistently despise this rabble, whether it obsequiously lavishes respect on you or whether it attempts to satiate its lust for sensationalism! I am impelled to tell you how much I have come to admire your intellect, your drive, and your honesty, and that I consider myself lucky to have made your personal acquaintance in Brussels. Anyone who does not number among these reptiles is certainly happy, now as before, that we have such personages among us as you, and Langevin(3) too, real people with whom one feels privileged to be in contact. If the rabble continues to occupy itself with you, then simply don't read that hogwash, but rather leave it to the reptile for whom i
einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter:
(1) your haters are trash
(2) you’re a baller, a true queen
(3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️
this is a good time to note that the proposed candidate for NIH director has never run a lab, cared for patients, led a major research and healthcare institution, or been a principal investigator on an NIH grant
The spheroid fusion analysis I did in this new study is much better than in my old paper!
I don't "fit" any dumb-bell 2D shape anymore to the data (unstable).
Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).
This circuit can be used to propagate a change in cell fate in 2D in a wave-like pattern… And also in 3D!
In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.
And look at this stunning synthetic biology!
Stunning optogenetic guidance!
🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇biorxiv.org/cgi/content/short/2024.1...
Good morning, and wtf is this
Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid.
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...
Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN
