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Posts by Roelfes Group

The conference will cover the full breadth of bioinorganic chemistry, including:
🔬 Metalloenzymes
⚗️ Biomimetic catalysis
💊 Metals in medicine
🌍 Environmental bioinorganic chemistry
🧬 Metal-based bionanotechnologies
🧪 Advanced methods to study metal–biomolecule interactions

1 month ago 2 0 0 0
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⏰ Deadline approaching!

The 15 March deadline for submitting abstracts for oral communications to EuroBIC18 is fast approaching!

We are excited to announce an outstanding lineup of plenary and keynote speakers – check them out on our website:
🌐 eurobic18.eu

1 month ago 5 4 1 0
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Last week I had the pleasure of attending the Netherlands’ Catalysis and Chemistry Conference (NCCC), where I presented my research on photobiocatalytic atroposelective biaryl coupling.

I’m excited to share that I was awarded the Royal Society of Chemistry @rsc.org EES Catalysis Best Talk Prize!

1 month ago 4 1 1 0
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📣 Thrilled to announce our incredible speaker lineup for the 2026 edition of #ETOC Online Symposium on April 29-30th.🗓️ Join us by registering today and to stay up-to-date! : tinyurl.com/ETOC2026-reg... (1/3)

2 months ago 13 8 1 1
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Engineering Fluoroacetate Dehalogenase by Growth‐Based Selections on Non‐Natural Organofluorides We present a high-throughput selection system to engineer fluoroacetate dehalogenases (FAcDs). By challenging E. coli populations that produce diverse FAcD libraries to grow on non-natural organofluo....

🥳🥳🥳 Our study on engineering enzymes to break C–F bonds is out in @angewandtechemie.bsky.social. Congrats to the brilliant & dedicated @suzannejansen.bsky.social for taking this step toward the remediation of #PFAS & other contaminating organofluorides!
onlinelibrary.wiley.com/doi/10.1002/...

2 months ago 9 6 0 0
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Season’s greetings from the Roelfes and Mayer groups! 🎉🎄
Warm wishes to our colleagues, collaborators, and friends across the community for a joyful holiday season and an inspiring New Year ahead. ✨🧪

4 months ago 4 1 0 0
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Our postdoc Valeria Poggetti @valeriapoggetti.bsky.social presented her work on Nucleophilic Catalysis in Thiophenol-Based Designer Enzymes at #NWOChains

@stratinghinst.bsky.social @rug.nl

4 months ago 2 0 0 0
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Last week I have defended my PhD in the beautiful Aula of the @rug.nl with a thesis entitled "Mapping the Sequence Landscape of an Artificial Enzyme". Such a huge diploma is proportionate to the immensely beautiful experience behind a PhD in the @roelfesgroup.bsky.social. Thank you very much to all!

5 months ago 5 2 0 0
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Upper half of a PhD position accountment in the field of biochemistry.

Upper half of a PhD position accountment in the field of biochemistry.

Lower half of a PhD position accountment in the field of biochemistry.

Lower half of a PhD position accountment in the field of biochemistry.

I am looking for a PhD student interested in enzymes!

For the full annoucement: www.chemzymes.com

6 months ago 12 10 0 1
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📢📢 New paper out!

AI and networks can be used to predict distal mutations in proteins, even in artificial enzymes!
Check out the article here
----‐> doi.org/10.1016/j.ij...

Thread 1/5 🧵

8 months ago 2 2 1 0
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Engineering fluoroacetate dehalogenase by growth-based selections to degrade non-natural organofluorides The widespread use of organofluorides in modern society has inadvertently led to the bioaccumulation of harmful pollutants, most prominently per- and polyfluorinated alkyl substances (PFAS). In princi...

With #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzannejansen.bsky.social, who has outdone herself in this project! (1/5)
www.biorxiv.org/content/10.1...

9 months ago 9 4 1 1
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Our postdoc @francdefel.bsky.social just gave a fantastic talk on gold-based artificial metalloenzymes for asymmetric catalysis. #Biotrans2025
@stratinghinst.bsky.social @rug.nl

9 months ago 6 1 0 1

Please also check posters 007 and 257 to find out more about radical biocatalysis and leveraging epistasis efficiently in artificial enzymes, respectively.
@stratinghinst.bsky.social

9 months ago 3 0 0 0
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#Biotrans2025 Gerard just gave an overview on recent advances in non-canonical amino acids application for novel artificial (metallo)enzymes from our group.

9 months ago 5 0 1 0
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#RepArtZymes pre-conference in Basel also brought together some of our old and current group members.
@zhizhou1619.bsky.social @reubenlg.bsky.social

9 months ago 9 1 0 0
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Our group members are attending #RepArtZymes Biotrans 2025 pre-conference. Gerard just presented our work on Artificial Metalloenzymes Featuring Thiol-Based Amino Acids. Compliments to the organisers #WardGroup for the fantastic program and a great get-together of the key players in our field.

9 months ago 9 0 0 0
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Great experience at the Green Chemistry & Engineering Conference! Amazing time around a neat program.

Extremely grateful for giving me the chance to share my work in an environment that pushes towards sustainable research

#GreenChemistry #MSCA

@acsgci.bsky.social @roelfesgroup.bsky.social

9 months ago 6 1 0 0
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Roelfes group - Open Positions PhD position on Hybrid biocatalytic cascades aided by Machine learning (1.0 FTE)

📢📢📢 PhD Opportunity!

Join our research group at RUG! We're seeking a motivated PhD student for a project on biocatalytic cascade processes combining natural and designer enzymes, supported by machine learning.
Click below to learn more — and feel free to share!

sites.google.com/rug.nl/roelf...

11 months ago 11 13 0 1

Very proud to share that one of my main PhD projects has been published in @chemicalscience.rsc.org, and that it has been selected as a #ChemSciPicks of the week paper!

Keep reading below for more details, or check out the full paper for free online: doi.org/10.1039/D5SC...

Thread ⬇️

11 months ago 19 2 1 1
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Check out this week’s #ChemSciPicks from Gerard Roelfes (@roelfesgroup.bsky.social, @stratinghinst.bsky.social) et al.!

‘Genetically Encoded 3-Aminotyrosine as Catalytic Residue in a Designer Friedel-Crafts Alkylase’

Read it here for free: doi.org/10.1039/D5SC...

#ChemSky 🧪

11 months ago 13 6 1 1

Had an amazing week at #ACSSpring2025! It was an intense but incredibly rewarding experience with top speakers and insightful discussions. I'm grateful for the opportunity to present my research in the biocatalysis session - awesome interaction! #MSCA @roelfesgroup.bsky.social

1 year ago 3 1 0 0
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Had an amazing week at the MetRaZymes @metrazymes.bsky.social Winter School in Hirschegg, Austria! It was a pleasure to learn, share, and connect with fellow researchers in our doctoral network. We organized and attended insightful lectures and workshops on ⬇️🧵

1 year ago 7 4 1 0
A spaceship as an allegory to an independent, self recycling system.

A spaceship as an allegory to an independent, self recycling system.

We are announcing about 30 PhD positions in the @fwf-at.bsky.social Cluster of Excellence Circular Bioengineering www.circularbioengineering.at/jobs
9 projects open in Progamme 2 (Self-Sustainable Microbial Systems) in 4 Austrian Universities

1 year ago 4 4 1 0

@stratinghinst.bsky.social
@unigroningen.bsky.social

1 year ago 1 0 0 0
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Huge congratulations to our former PhD student Reuben @reubenlg.bsky.social on winning the KNCV-DCS Thesis Award from the Dutch Catalysis Society for his outstanding PhD research in our group! A well-deserved recognition of his hard work and dedication. 🎉

1 year ago 10 1 1 0
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Tanja presented her work on metallaphotoredox catalysis in designer photoenzymes.
Congrats to both of you!
@stratinghinst.bsky.social @unigroningen.bsky.social

1 year ago 4 1 0 0
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Our group members Tanja and Franco @francdefel.bsky.social presented their exciting research at NCCC this week.
Franco talked about his work on asymmetric catalysis in gold-based artificial metalloenzymes.

1 year ago 3 1 1 1

This accomplishment would not have been possible without the tireless work of Ru Jiang and @fabricas.bsky.social and the expertise of Andy-Mark Thunnissen in solving the holoenzyme structure.
Great work everyone! 🏆

1 year ago 0 0 0 0
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An artificial copper‐Michaelase featuring a genetically encoded bipyridine ligand for asymmetric additions to nitroalkenes Artificial metalloenzymes (ArMs) are an attractive approach to achieving “new to nature” biocatalytic transformations. In this work, a novel copper-dependent artificial Michaelase (Cu_Michaelase) com...

Check it out here: onlinelibrary.wiley.com/doi/10.1002/...

1 year ago 0 0 1 0

The excellent properties of the evolved artificial metalloenzyme enabled its application in preparative-scale synthesis, yielding valuable synthons for the production of pharmaceutical compounds.

1 year ago 0 0 1 0