A dual sensor regulates P-glycoproteins structural plasticity www.biorxiv.org/content/10.64898/2026.03.13.711505v1 #cryoEM

ABC transporter Pgp in membrane. Blender Rendering

Great to see one of my PhD projects out on bioRxiv. We report "A dual sensor regulates P-glycoproteins structural plasticity." Congrats to Michael Kamel for doing the heavy lifting from
@arnemoeller.bsky.social
& Urbatsch Lab. doi.org/10.64898/202... #b3d #cryoEM

What an inspiring few days at the #WEHeraeusSeminar! Great science, lively discussions, and lots of fun with the amazing community of #cryoEM, #StructuralBiology & #Microscopy. Huge thanks to everyone!

#STEM meets #cryoEM - Carsten Sachse @sachsegroup.bsky.social gave us a glimpse of just how far we might go 🚀🔬 #WEHeraeusSeminar #StructuralBiology #Microscopy @arnemoeller.bsky.social

Bringing colour to #cryo-EM - establishing methods for metal assignment in cryopreserved complexes! Fantastic talk by Bonnie Murphy!
#WEHeraeusSeminar #StructuralBiology #Microscopy @arnemoeller.bsky.social @mpibp.bsky.social

Cristina Paulino @cpaulino.bsky.social, provocative as always - sparking thoughts on male contraception!
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Philipp Sebastian Erdmann @3p1l.bsky.social showed how SOLIST boosts cryo lift-out: more stability, more throughput! 🚀
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Arjen Jacobi @cryotud.bsky.social presented novel cryo-EM specimen carriers, enabling time-resolved studies in a conceptually new way. Fantastic work!
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Sybodies and libraries: both have shelves full of things that stick
😀🧬📚 It’s always so fun listening to Markus Seeger @seegerlab.bsky.social! #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Henriette Autzen introduced novel polymers for detergent-free membrane protein extraction. #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Steven De Gieter shared his secret recipe for purifying a protein of interest out of the soup of molecules! 🍜
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

#MassSpec + #CryoEM = novel specimen preparation!
Engaging talk by Tim Grant, addressing the tricky issues of sample dehydration, rehydration, and compaction.
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Filamentous phage vs. spaghetti - tough choice, but dinner wins 🍝😄 As always, a fantastic talk by Vicky @the-gold-lab.bsky.social! #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Mind-blowing presentation by Henning Stahlberg - exploring the structural basis of neurodegeneration and pushing the boundaries of #cryoEM!
#WEHeraeusSeminar #StructuralBiology #Microscopy @arnemoeller.bsky.social

Fascinating talk by Phil Stansfeld @pstansfeld.bsky.social - a great reminder of how beautifully #cryoEM and MD simulations complement each other! 😃
#WEHeraeusSeminar #StructuralBiology #Microscopy @arnemoeller.bsky.social

A molecular atlas of the cell motility machinery - beautifully presented by Florian Schur @schurlab.bsky.social
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Fully confidential - typical #cryoEM reviewers😁
Becky @rebeccathompson.bsky.social, it was so nice meeting you again! And thanks to you & Thermo Fisher for covering the bar tab! 🍻😏
#WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

We are very happy to have you here! Thanks for the fascinating talk!

We all love colours, especially, when they can be generated automatically! Fantastic talk by Danielle Grotjahn @nanigrotjahn.bsky.social linking method development, structural biology and cell biology! #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

From the early days at the “Laboratorium für Übermikroskopie” to today’s cutting-edge Cryo-FIB milling - Jürgen Plitzko showed us how far in situ structural biology has come, and where it’s heading! #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

Wanda Kukulski reminded us how much there’s still to learn about apoptosis and how different results can look in vitro vs. in situ! #WEHeraeusSeminar #cryoEM #StructuralBiology #Microscopy @arnemoeller.bsky.social

#CryoEM on the move! Yesterday evening, Werner Kühlbrandt opened the WE-Heraeus Seminar with an inspiring journey from 2D crystallography to cutting-edge in situ tomography ❄️🧊🔬 #StructuralBiology #ScienceSeminar #Microscopy @arnemoeller.bsky.social

Deadline extended: Apply by June 30! Scientific organizers @arnemoeller.bsky.social #cryoEM

🚨 Last week to apply! Join the WE-Heraeus Seminar #CryoEM on the Move: New Applications and Challenges 🧊🔬
📅 Sept 14–17, 2025 | 📍 Bad Honnef, Germany
✅ No fee, full-board covered!
🔗 Apply now: indico.we-heraeus-stiftung.de/event/24/reg...

#CryoEM #StructuralBiology #ScienceSeminar #Microscopy

Dear all,

I am very excited about the upcoming 842 WE-Heraeus-Seminar #Cryo-EM on the Move. @djanuliene.bsky.social and I are looking forward to a great conference with many exciting speakers!

Grateful for all involved in getting me here! @dfg.de @arnemoeller.bsky.social Off to new cryoEM adventures!

Perfection.

Don‘t mix Jena with Vienna!
Ute @hellmichgroup.bsky.social is revealing the mystery of allosteric nucleotide sensing in ABC transporters at #ABC2025

Arne @arnemoeller.bsky.social introducing the speakers of the morning session with a great reminder of why controls matter!

Take away:
Worms on the grid?
Maybe your protein is not it! 🐛🤣

The ABC transporter MsbA in a dozen environments High-resolution structure determination of membrane proteins typically requires isolation from the native lipid bilayer and reconstitution into artificial membrane mimics. For this purpose, numerous d...

Annika Baier from @arnemoeller.bsky.social Lab is kicking off the afternoon session! You think you know your transporter? Not until you've seen it at least in a dozen different environments! 🥰
Maybe you can clarify a longstanding controversy along the way
www.biorxiv.org/content/10.1...