What I learned as student: #Polymerases need a DNA template to make more of it... WRONG WRONG WRONG

#DRT3 doesn't need it, can do it by using its own structure as template.

Science is beautiful and full of surprises

www.science.org/content/arti...
Paper: pubmed.ncbi.nlm.nih.gov/41990131/

Been through some storms, but hard work has paid off. Thanks @ucatolicamaule @facmedicinaucm

With new energy back what I love...how to manipulate the immune system to fight diseases.

#promotion #fullprofessor #immunotherapy #cancer #scienceworks

Expected, considering how Twitter changed since it was taken over.
arstechnica.com/science/2025...

‘Corrupt’ medical journals have to change, RFK Jr. says, or the NIH will publish in-house The criticism of The Lancet, NEJM and JAMA is not new, but the health secretary may use his position to influence research that journals publish.

Yeah right, they are all corrupt. What is his agenda? Ridiculous!

I could agree that they take too much $ for publications, hiding important papers behind pay walls, etc. but corrupt?

www.statnews.com/2025/05/27/r...

Basic research advances science, and can also have broader impacts on modern society Basic research that doesn’t have a specific industrial or experimental application still adds value outside the lab by engaging people with exciting research.

Without basic science, translational, applied sciences wouldnt be possible. It is fundamental!!
No immunotherapy, no flying, no smart phones, no smart TV...and so on and so on...

Basic research advances science, and can also have broader impacts on modern society
theconversation.com/basic-resear...

Could it be a combination of both?

FDA approves nivolumab with ipilimumab for hepatocellular carcinoma On April 11, 2025, the FDA approved nivolumab with ipilimumab for the first-line treatment of unresectable or metastatic hepatocellular carcinoma.

FDA approves nivolumab with ipilimumab for unresectable or metastatic hepatocellular carcinoma www.fda.gov/drugs/resour...

Nice paper @idoyagalab.bsky.social, very interesting. Besides GM have you looked at the B16 cells itself as immunosuppressive on MoDC after recruitment of monocytes into the tumor and their maturation into Cd301b+ MoDCs?

Sometimes, science could be so easy.

Vaccines work ... Or was it thoughts and prayers?

New immunotherapy strategy targets macrophage receptors to enhance melanoma treatment Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO. Their study, published...

Preclinical - targeting MARCO on macrophages in combination with CTLA4 enhances Melanoma regression in mice - but not with anti PD1
medicalxpress.com/news/2025-03...

Suppressing key protein may unlock immunotherapy for glioblastoma Glioblastoma has remained one of the toughest cancers to treat, resisting even the latest advances in immunotherapy. But new research from Sylvester Comprehensive Cancer Center, part of the University...

Viral mimicry to enhance cancer immunotherapy
medicalxpress.com/news/2025-03...

Over 130 scientists warn: Damage to NIH will be irreversible - The Boston Globe Even the threat of cuts has had a chilling effect. The path that the administration is on will devastate STEM research in America. Leaders of universities and hospitals and scientists across the count...

Reality

"Damage to NIH will be irreversible"

www.bostonglobe.com/2025/03/13/o...

The US military has cared about climate change since the dawn of the Cold War – for good reason During the Cold War, the US poured support into Arctic military outposts and climate research amid fears of a Russian invasion. Climate change is still on the military’s radar as a threat multiplier.

Someone should tell the current administration.

"Over time, the U.S. military would come to see climate change as both a threat in itself and a threat multiplier for national security."

theconversation.com/the-us-milit...

Science works, b***

Mayo Clinic Researchers Identify Proteins Linked to Immunotherapy Resistance in Metastatic Colorectal Cancer A discovery by researchers from Mayo Clinic may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer.

Potential biomarker?

Fibronectin and smooth muscle actin within colorectal cancer tissues are associated with resistance to immunotherapy treatment.
www.onclive.com/view/mayo-cl...

Link to the paper: 10.3390/nu17030534

Drinking White Wine Could Be Increasing Your Risk of Cancer Epidemiologists evaluate the potential cancer-protective effects of red wine by comparing its associated cancer risks to those of white wine. Not all alcoholic beverages are perceived equally, with re...

Drinking White Wine Could Be Increasing Your Risk of skin Cancer

scitechdaily.com/drinking-whi...

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

When politics overrule science. Very sad to read this:
NIH to terminate hundreds of active research grants
www.nature.com/articles/d41...

PubMed is down. I am currently going cold turkey and experiencing severe withdrawal symptoms. #PubMed please come back, I need you urgently.

Mice fed artificial sweetener exhibit alarming health issues Aspartame, a common sweetener in diets, could affect vascular health, according to a new study that warns of a possible higher arterial risk.

No, artificial sweeteners are not better than sugar (avoid both, but if you have to better use sugar). Another evidence (how many we need to get rid of them?):

Mice fed artificial sweetener exhibit alarming health issues www.earth.com/news/mice-fe...

Child in West Texas is first US measles death in a decade | CNN The first measles death in the growing outbreak in West Texas was a school-aged child.

After first measle death. Kennedy about measles “So it’s not unusual. You have measles outbreaks every year.” - NO you dont if you get vaccinated. edition.cnn.com/2025/02/26/h...

Opinion | American Science is Under Attack (Gift Article) The Trump administration hobbles research and endangers the public health.

Sad, but well said. NIH funding www.nytimes.com/2025/02/14/o...

I see a lot of combo trials with ICIs, but most fail. We need to be smarter how to choose combos to select patients who are more likely to benefit.

Five latent factors underlie response to immunotherapy - Nature Genetics Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden,...

How can we predict which patients respond to cancer immunotherapy? Here's a potential path: scitechdaily.com/scientists-i...
and here's the paper: www.nature.com/articles/s41...

More evidence here:
www.news-medical.net/news/2025021...
And here the paper: www.nature.com/articles/s41...

Microbiome immunotherapy cancer ici

Microbiome and ICI: potential synergy for better cancer treatments www.jci.org/articles/vie...

The Race to Explain Why More Young Adults Are Getting Cancer Researchers are racing to find out.

The Race to Explain Why More Young Adults Are Getting Cancer

time.com/7213490/why-...

Bye-bye X, enough is enough. I'm interested in science and, to say it nicely, not the things that are offered now. Looking forward to bluesky and hope to find it similar informative as old twitter was.