Thank you @foglizzomartina.bsky.social for the nomination, and thank you to everyone for your support.

This recognition reflects the creativity and hard work of our entire team, past and present, as well as the many collaborators whose contributions make our discoveries possible.

The larger SUMO family.

Our new Essays in Biochemistry review frames the DNA double strand break repair as multifunctional molecular machinery, showing how flexible our repair systems safeguard genomes from damage and help shape better cancer therapies 🧪 https://doi.org/10.1042/EBC20253043

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4

Preprint: www.biorxiv.org/content/10.6...

Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.

ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

We just published a commentary on Francesca Bufalieri’s new article in a Molecular Therapy that shows the power or tweaking the UPS to modulate Hedgehog signalling in cancer. With @zeqiraj.bsky.social and Kevin Shi.

authors.elsevier.com/a/1mBKX5QliS...

I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:

Interphase cell morphology defines the mode, symmetry, and outcome of mitosis During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

Thanks Malte.

First post on here to mark the lab's first paper of the year. It's a belter. The product of several collaborations, many techniques skilfully applied and incredible persistence. 1/n doi.org/10.1083/jcb....

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social

🔬Sibling rivalry alert!
Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡
Exciting times ahead!

Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌
#cryoEM #cryoET

Thanks Rune.

Thanks Kei. Fingers crossed!

Huge thanks to our funders @wellcometrust.bsky.social who generously funded the project. Their long-term support for our lab has made this possible especially because the project started over a decade ago, throwing many surprises along the way!

Molecular Glues: drugging the undruggable YouTube video by Phospho Biomedical Animation

A fully narrated animation by our amazing friends at Phospho Biomedical Animation is linked below. Worth a watch.
youtu.be/wuFVeW6eCPg?...

Amazing efforts from first author @francescachandler.bsky.social and collaborators Roger Greenberg, Joseph Salvino, Francesco Del Galdo and their teams. @pennmedicine.bsky.social @wistar.org @astburycentre.bsky.social @astbury-bsl.bsky.social
@antoncalabrese.bsky.social
@bioscienceleeds.bsky.social

Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF

Molecular glues that inhibit deubiquitylase activity and inflammatory signaling - Nature Structural & Molecular Biology The BRCC36 isopeptidase complex (BRISC) is a deubiquitylase that stabilizes interferon receptors, driving inflammation. We discovered ‘BRISC molecular glue’ inhibitors (BLUEs) that selectively inactiv...

Very happy to share the work from my PhD is out today in @naturesmb.bsky.social !

Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827 Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK-inhibitors availab...

New pre-print from the lab @cbmr.science spearheaded by PhD student, Conchita Bringas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social; providing structure-based molecular insights & cellular actions of the recently identified potent #AMPK inhibitor, BAY-3827.

Large-Scale Protein Production and Activity Assay Protocols for Human Glycogen Synthase-Glycogenin Complex Glycogen synthase (GS) is the rate-limiting enzyme for glycogen production and together with glycogenin (GN) and glycogen branching enzyme (GBE), can generate glycogen particles containing up to 50,00...

Out now: Our method article describing large scale production & enzyme activity measurements of human glycogen synthase-glycogenin (GS-GN) complex published in the MIMB book series. Lead by researcher, Dipsikha Biswas & in collaboration with @zeqiraj.bsky.social @universityofleeds.bsky.social