The image is of regenerating motor neuron axons in culture, captured by confocal microscopy.

A team of scientists deciphers how high levels of glucose impair cognitive function in diabetes, new research sheds light on how the neurotrophic factor BDNF critically supports the repair of motor neuron axons, and more this week in #ScienceSignaling. https://scim.ag/3Q5x6Bq

"Low-carb" is not one thing.
Verified ketosis, Mediterranean diet, and unverified carb restriction are three distinct states predicted to produce different immune outcomes in IBD. The middle one — the most studied - may be least informative. Each prediction is falsifiable.
#Immunosky #Gastrosky #IBD

No human study has measured diet, bile acids, and Th17/Treg balance simultaneously in IBD. A 2026 JCC mouse study and a 2022 Nature paper converge on Treg expansion — via BHB, via bile acids. This preprint proposes a cross sectional test of diet on both.
#MucosalImmunology #OpenAccess
#IBD

Graphical abstract: committed diets restore bile acid signaling (FXR/TGR5/RORγt) shifting Th17/Treg toward mucosal tolerance; intermediate restriction predicts uncertain outcome. IBD hypothesis.

Half of “keto diet” IBD trials never confirmed ketosis. No blood BHB — just carb restriction of unknown depth. This preprint proposes why that gap explains contradictory results, and a design to test it.
preprints.org/manuscript/202603.0416/v5
#IBD #GutMicrobiome #BileAcids