Very excited to share new work from our lab by Dr. Sarah Cash!

👉**Liver-specific loss of the transcriptional coregulator ARGLU1 protects against diet-induced obesity in mice through decreased lipid absorption
www.biorxiv.org/content/10.6...

#coregulators #bileacids

#BileAcids are essential for fat digestion and metabolic balance—but how are they transported across cell membranes?

Just published in @nature.com, a #PKUResearch team led by Prof. Lei Xiaoguang, together with collaborators, reports cryo-EM structures of the human bile acid transporter OSTα–OSTβ.

Study shows that neonatal #betacells sense gut microbiota-derived #bileacids via #FXR, limiting their development. Declining postnatal beta cell FXR expression allows normal neonatal beta cell growth and reduces #diabetes risk link.springer.com/article/10.1...

New gut-targeted therapy shows promise for C. difficile infections – BioNews Central In a major step toward precision therapy for C. difficile infection, researchers have uncovered how the body’s bile acids bind to and block the bacterium’s most dangerous toxin. ...

In a major step toward #PrecisionTherapy for #CdifficileInfection, researchers have uncovered how the body’s #BileAcids bind to and block the #bacterium ’s most dangerous #toxin.
#Clostridioidesdifficile #Cdifficile #GutHealth

Serum bile acid profiles may help identify central precocious puberty in girls, offering a less invasive diagnostic approach.

#Meded #SoMe4PedSurg #Pediatrics #PublicHealth #CentralPrecociousPuberty #BileAcids #Biomarkers #Metabolomics

link.springer.com/article/10.1...

It is important that patients are provided with clear guidance and information about available therapies, e.g. medications and dietary interventions, from the time of early diagnosis. Additionally, further research is needed to fully understand the role of #bileacids in the pathogenesis of #IBD. 3/

🔬A highly interesting research poster presented at the #ECCO2025 conference in Berlin this year by Van der Kruk et al. highlighted microbially conjugated #bileacids (MCBAs) as potential biomarkers for dietary therapy outcomes in pediatric patients with #crohnsdisease. 1/

Bile Acid Malabsorption: a potential underlooked and underestimated component of active disease in Inflammatory Bowel Disease - todaysinsightsibd A person living with inflammatory bowel disease may experience bile acid malabsorption which affects the gastrointestinal system and leads to physical and

#WorldIBDDay has ended, but my commitment to raising awareness about #bileacidmalabsorption continues. Read more in this new article which covers some of the essentials & treatments of BAM & some important studies that highlight the role of #bileacids in #IBD. ➡️ todaysinsightsibd.com/bile-acid-ma...

This new Short report studies trans-right #ventricle #metabolite gradients in individuals with #obesity and identifies representation of molecular pathways including #fattyacid oxidation, #bileacids and #acylcarnitines.

doi.org/10.14814/phy...

Thousands of metabolic features were driving these separations across tissues. Alterations were observed in the #bileacids pool (obviously😉) but also in N-acyl lipids, B vitamins, neurotransmitters, polyamines, and several other classes of molecules. 4/n

Taxonomic identification of bile salt hydrolase‐encoding lactobacilli: Modulation of the enterohepatic bile acid profile Based on our previous work, Lactobacillus was identified as a crucial genus encoding bile salt hydrolase (BSH). Sixteen species of lactobacilli were obtained and classified into four typical categori....

Taxonomic identification of bile salt hydrolase‐encoding #lactobacilli: Modulation of the enterohepatic bile acid profile onlinelibrary.wiley.com/doi/full/10....
#BileAcids #microbiome #Bioinformatics #hydrolase

🧬 Your gut microbes help manage cholesterol by controlling bile acid production! 🦠💪 New research highlights how this partnership supports fat digestion & metabolic health.

More from @GMFHx: 🔗 zurl.co/nbqV4

#GutHealth #Microbiota #Cholesterol #BileAcids #MetabolicHealth #GMFH2025

Featured today by @MSKLibrary: Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

#LiverCancer #TumorImmunology #BileAcids #TCellResponse #CancerImmunology #HepatocellularCarcinoma #ImmunotherapyResearch

dx.doi.org/10.1126/scie...

Interactions between Parabacteroides goldsteinii CCUG 48944 and diet ameliorate colitis in mice via regulating gut bile acid metabolism In this study, we explored the therapeutic effects of Parabacteroides goldsteinii (P. goldsteinii) on colitis and its underlying mechanisms. Our results indicate a significant reduction of P. goldste...

Interactions between #Parabacteroides goldsteinii CCUG 48944 and #diet ameliorate #colitis in mice via regulating gut bile acid metabolism #iMetaOmics onlinelibrary.wiley.com/doi/full/10....
#microbiome #metabolism #IBD #BileAcids

Figure showing the effects of bile acids on metabolic tissues.

From our latest issue: Marti Cadena Sandoval & Rebecca Haeusler outline the interplay between #BileAcids and #metabolic pathways and also discuss the systems that can be used to research these connections (£) go.nature.com/42c8quk

Gut bacteria promote healing of colon mucosa – BioNews Central The bacterium Clostridium scindens plays a crucial role in gut healing by converting primary bile acids, indicating potential therapeutic uses for ulcerative colitis and similar conditions. ...

The bacterium #Clostridium scindens plays a crucial role in #GutHealing by converting primary #BileAcids, indicating potential #therapeutic uses for #UlcerativeColitis and similar conditions.
#GutHealth #GutBacteria

Trajectories of microbiome-derived bile acids in early life - Insights into the progression to islet autoimmunity Recent studies reveal that gut microbes produce diverse bile acid conjugates, termed microbially conjugated bile acids (MCBAs). However, their regulation and health effects remain unclear. Here, we an...

Happy to share this preprint from our team, great collaboration with Mikael Knip, @pieterdorrestein.bsky.social, @lahesmaalab.bsky.social, and @petterbrodin.bsky.social . Special kudos to @santoshlamichhane.bsky.social.
www.medrxiv.org/content/10.1...
#T1D #bileacids #autoimmunity #metabolomics

Research Associate-Fixed Term - East Lansing, Michigan, United States Position Summary We are looking to hire a postdoctoral scholar to study the role of microbial bile acid metabolism in host/microbiome crosstalk related to gut inflammation and GI health. This position...

We are hiring a #postdoc !!! Looking for a motivated scientists to explore the role of new #bileacids made by the microbiome. Apply apply apply!! Share share share!!!
careers.msu.edu/jobs/researc...

#Bileacids and their receptors in #hepatic #immunity
www.sciencedirect.com/science/arti...

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

Exciting work from Sue Kaech’s lab @tcellogic.bsky.social

Tissue specific metabolites like #BileAcids in #Liver affect #CD8Tcell tumour responses

#immunometabolism #immunosky

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer www.science.org/doi/10.1126/...

Thank you, @ucsdpharmacy.bsky.social!
It was a privilege to receive the award from Metabolomics Association of North America (MANA) and discuss the exciting work on #bileacids. Also, a big thanks and shoutout to my mentor @pieterdorrestein.bsky.social for his continued guidance and support :)

Beyond #metabolic messengers: #Bileacids and TGR5 as pharmacotherapeutic intervention for #psychiatric disorders
www.sciencedirect.com/science/arti...

New role for bacterial enzyme in gut metabolism revealed | Penn State University Synthesized from cholesterol in the liver, bile acids long have been known to play a role in human metabolism. A team led by Penn State researchers has uncovered the mechanism by which bacteria in the...

At #8, this story highlights research led by Andrew Patterson to better understand the health implications of bacterial interactions with #bileacids, and the formation of new compounds like bacteria bile acid amidates (BBAAS). 🦠⚕️

🔗Read the story: www.psu.edu/news/agricul...