A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
The key global crops, wheat, rice and maize, are expected to see the losses to pests increase by about 46%, 19% and 31% respectively when global heating reaches 2C 👇 www.theguardian.com/global-devel...
New EMBO J
𝘔𝘺𝘤𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘵𝘶𝘣𝘦𝘳𝘤𝘶𝘭𝘰𝘴𝘪𝘴 uses “on-off switch” to pause or restart its growth
DarT tags DNA to halt replication, DarG removes the tag to resume activity
Stop-start mechanism helps TB evade antibiotics and immune clearance, establish chronic infection
www.embopress.org/doi/full/10....
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, a close collab between my PhD lab (Liu group) and @sternberglab.bsky.social, has been such a fun journey to help lead. Huge thanks to all contributors!
www.science.org/doi/10.1126/...
www.nature.com/articles/d41...
Coverage of our collaboration with the Liu group..
' “This is crazy directed evolution!” - Makoto Saito'
Tomorrow, Tuesday March 25th at 11am ET, @jpassmore.bsky.social from Utrecht University, The Netherlands, will present "Outcome-driven microscopy: integrating smart microscopy and optogenetics for precise biological control"!
Join us on Zoom, more information on biocontrolseminars.org
Chart showing the chemical structures of the common amino acids as well as brief notes of their tastes. The latter are taken from: https://doi.org/10.3758/BF03203878 https://doi.org/10.1016/0031-9384(81)90298-5 The original chart is modified from one made by @etymology_nerd on "How amino acids got their names" available e.g. here: https://x.com/etymology_nerd/status/1310560462329831425
How amino acids taste 🧪
A number of people who run those resources were contractors. In December, some of them were transitioned into Federal employee status to protect them.
Unfortunately, this means they were probably on the list of employees with probationary status.
I am trying to find out what actually happened.
Birth defects are the #1 cause of death in the first year of life (🧵). Birth defects kill more than twice as many children as cancer. Birth defects are diseases of developmental biology. Here are CDC statistics for 2021. 1/5
wisqars.cdc.gov/pdfs/leading...
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
A seminar on the history of protein structure prediction and protein design. By Mohammed AlQuraishi
youtu.be/Ahwn-KS8fd0?...
To me, it looks like a Reduviids, predatory insect.
1/2: MSK is the first hospital in New York City to offer gene therapy for sickle cell disease and beta thalassemia through its pediatric program, MSK Kids. Learn more: bit.ly/4gUKC3a
191 children with diverse solid tumors, immune variation with age and tumor type provide a reference for future precision immunotherapies tailored for the evolving immune systems of children
www.cell.com/cell/fulltex...
@cellcellpress.bsky.social @petterbrodin.bsky.social
