Aberrant splicing in Huntington’s disease accompanies disrupted TDP-43 activity and altered m6A RNA modification - Nature Neuroscience Nguyen et al. identify TDP-43 and METTL3 as key regulators of disrupted RNA splicing in Huntington’s disease, offering insight into how TDP-43 mislocalization and aberrant m6A RNA modification and loc...

Interesting role for m6A in RNA processing!

www.nature.com/articles/s41...

Awesome resource for #childhoodcancer researchers from @kentsisresearch.bsky.social !

mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!

So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!

www.cell.com/molecular-ce...

Learn more about Molecular Mechanisms in RNA Biology with this joint collection of the latest Reviews and Perspectives from @CellChemBiol and @MolecularCell http://dlvr.it/TH4dtW

Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end.
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...

www.sciencedirect.com/science/arti...

Created a starter pack to grow the pediatric neuro oncology community here!

go.bsky.app/VTHk2qy

mRNArchitect: optimized design of mRNA sequences Summary: mRNA design is the critical first step in the development of a new vaccine or therapy. The mRNA primary sequence is assembled from multiple elements, including the coding sequence of the targ...

There are more ways to design an mRNA than atoms in the universe, so how do you choose the best one? Our new @basemrna.bsky.social software, mRNArchitect enables you to tune expression, stability, reactogenicity and synthesisability to design more potent #mRNA drugs.

www.biorxiv.org/content/10.1...

So cool!

A modular platform for bioluminescent RNA tracking - Nature Communications Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

Nice paper from Jenn Prescher and colleagues on tags for bioluminescence imaging of RNAs. www.nature.com/articles/s41...

Would love to join!

Controlling Transcription Elongation and Termination: More Than a Means to An End

A special JMB issue on Transcription elongation and termination with really great reviews including @triggerloop.bsky.social @voslab.org @lucas.farnunglab.com

www.sciencedirect.com/science/arti...

RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity Yanas et al. report that RNA helicases DDX3X and DDX3X form nanometer-scale RNA-protein clusters (RPCs) both in vitro and in cells. Differences in RPC size and catalytic activity between DDX3X and DDX...

www.cell.com/current-biol...

Sex differences in RNA biology. #RNASky

Time for Pediatric Cancer Starter Pack! go.bsky.app/2UbwR5L

But can you please add me :)

On a roll Piotr! 🙋🏻‍♀️🙋🏻‍♀️

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

RNAkinet identifies nascent RNA by predicting 5EU metabolically labeled #RNA from raw #nanopore electrical signal. Should allow association of RNA metabolism dynamics with isoform usage, poly(A) tails and native RNA mods. academic.oup.com/nargab/artic...

Graphical abstract of the paper.

How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...

Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!

Created a pediatric neuro oncology group. Please message to grow the community!

go.bsky.app/VTHk2qy

RNA modifications Join the conversation

Hi #RNAsky, I've made a much needed #RNA modifications starter pack!
Let me know if you’d like to be added or know someone who should be.
go.bsky.app/E7zXGSF
#RNAmodifications

Would love to join if able! Thanks so much

Would love to join!

m6A sites in the coding region trigger translation-dependent mRNA decay Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degrad...

Interesting role of m6A in the coding sequence of RNA

www.cell.com/molecular-ce...

What a nice tool!

Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025

Hi Piotr! Would love to join if space :)

Would love to join :)