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Posts by Holthuis Lab

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Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

☕ @mathilda95.bsky.social @nadlerlab.bsky.social & co introduce a correlative light and electron #microscopy workflow, Lipid-CLEM, combining near-native #lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively analyses lipids in membrane nanodomains.
bit.ly/4moYLJH

1 week ago 41 21 1 1
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The 2026 Otto Warburg Medal winner Maya Schuldiner received the medal from @volkerhaucke-lab.bsky.social after a moving laudatio by Christian Ungermann Thanks to @elsevierconnect.bsky.social for the continuous support!

3 weeks ago 43 8 0 1
Lipid Code to Life Modern lipid biology has evolved far beyond the traditional view of lipids as simple building blocks or energy substrates. Lipids are now recognised as dynamic regulators of biological structures and…

Looks like a great @embo.org workshop coming in September: “Lipid Code to Life”, with a who’s who of lipid #biochemistry… (e.g. @dimovalab.bsky.social @holthuislab.bsky.social @sciezgin.bsky.social etc ) More info and registration: meetings.embo.org/event/26-lip... #lipids #biophysics

3 weeks ago 23 8 0 0
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New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social

2 months ago 152 39 1 5
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How did life arise from simple chemical building blocks?

New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.

Read more: mrclmb.ac.uk/news-events/...

2 months ago 53 31 0 2
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📯Congratulations to Tobi Adeosun, who defended his PhD thesis on “transbilayer lipid dynamics & inter-organellar lipid transfer in lysosomal repair” with flying colors today 🎩 and joined Saron Tooze’s lab at the Crick Institute, leaving behind a proud and tipsy Doktorvater 🥂

2 months ago 9 1 1 0
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Modern lipid biology has grown far beyond its roots. Advanced technologies offer novel opportunities to unravel the role of lipids in the organization of biological systems. Build on this momentum and join The EMBO Workshop "The Lipid Code to Life" Sept 7-11, 2026 meetings.embo.org/event/26-lip...

3 months ago 17 6 0 0
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Have you registered yet? Early bird registration and abstract submission are open until January 31.
mosbacher-kolloquium.org

3 months ago 10 8 0 3

Do register! It is really worth it, I promise!

3 months ago 11 5 0 0
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The lipid code to life 7–11 September 2026 | Dresden, Germany

Please sign up on coming-soon.embo.org/w26-51 to be informed once the website is live. We are very very very much looking forward to welcoming you to Dresden, one of the most lipid-loving cities, next year!

4 months ago 5 1 1 0
copyright Palina Nepachalovich of ZML Dresden

copyright Palina Nepachalovich of ZML Dresden

Ups we did it again! Please mark your calender. EMBO Workshop “Lipid Code to Life”, taking place September 7–11, 2026, in Dresden, organized by Maria Fedorova, @lipid.bsky.social, Valerie O'Donnell, @holthuislab.bsky.social and @molcellbiophys-lab.bsky.social 🥳 Retweets = lipidlove

4 months ago 45 37 1 1

Key determinants of VDAC-hexokinase I complex assembly revealed by a minimal vesicle-based interaction assay www.biorxiv.org/content/10.1101/2025.11....

5 months ago 4 2 0 1
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An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

5 months ago 388 169 10 22

Such a worthy recipient. Maya is not only a great scientist but also a fantastic mentor and a rich source of inspiration.

5 months ago 10 5 0 0

📯 shoutout for this beautiful work by Kenji Maeda’s lab, who mapped 300 lipid species across 6 compartiments of humane cells. Besides uncovering general principles of lipid organization, the paper establishes a framework for exploring how lipid landscapes are regulated in physiology and disease 👇🏼

5 months ago 9 4 0 0

Thank you, Giovanni!

5 months ago 0 0 0 0

Thank you, Andre.

5 months ago 1 0 0 0
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Thank you, Rachid. Let’s see what the reviewers think…

5 months ago 1 0 0 0
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Our data collectively support a model according to which VPS13C acts upstream of OSBP/ORP lipid transport proteins to orchestrate bulk lipid transport in synchrony with lysosomal damage and repair, thereby maintaining lysosome integrity

5 months ago 3 0 0 0
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As ER-lysosome contact sites bridged by VPS13C have a gap width that cannot be resolved by light microscopy, we used a ratiometric approach to simultaneously trace fluorescence levels of ER-derived lipids & ER membrane proteins on the surface of damaged lysosomes containing pHrodo-labeled microbeads

5 months ago 3 0 1 0
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VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

5 months ago 44 20 2 2
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🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...

6 months ago 12 12 0 0
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🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...

6 months ago 12 12 0 0
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I am proud to 📣 today’s superb thesis defense by Milena Wessing on “Molecular dissection of ceramide-induced apoptosis: a bottom-up approach”. Two papers describing Milena’s heroic efforts are close to submission. It was a privilege serving as her “Doktorvater” 🥂

6 months ago 2 0 0 0

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I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂

6 months ago 5 1 0 0

Great to see this work on imaging cellular lipid logistics in Nature, where it belongs. Chapeau! Many gratulations to Andre, Alf and their co-workers!

7 months ago 7 2 1 0
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That’s fantastic news, Fikadu! And very much deserved. Many congratulations, also to OHSU for this wise decision 🍾🍾🍾

9 months ago 0 0 0 0

🔥🔥🔥 (= highly recommended) 👇🏼

9 months ago 5 0 0 0

A university & its leadership standing for academic freedom, truth, integrity & shared values deserve support from across the globe. Those believing in these virtues greatly outnumber those who seek to undermine them. As admirer of the 1st class scientists working at UVA, I gladly signed the letter👇

9 months ago 5 2 1 0
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Wir für Demokratie | Unabhängig & Überparteilich Demokratisches Engagement Für Dich. Für mich. Für uns alle. Wir sind ein gemeinnütziger Verein, der einen niedrigschwelligen Zugang zu demokratischer Beteiligung ermöglicht. Als Plattform für überpart...

Science is the engine of an open, pluralistic society. So scientists serve a central role in defending it. In 🇩🇪, the association „Wissenschaft für Demokratie – Wir für Dich“ was founded to strengthen the role of science in the public debate & in the fight against disinformation
wirfuerdemokratie.org

10 months ago 3 0 0 0