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Posts by Dr. A

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a woman sitting in front of a microphone with her mouth open and says i am so proud of all of you ALT: a woman sitting in front of a microphone with her mouth open and says i am so proud of all of you

Wow. What an amazing achievement! Congratulations!

9 months ago 2 0 1 0
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Coco Gauff becomes the youngest American to win Roland Garros since Serena Williams in 2002.

Legacy.

🇺🇸❤️

10 months ago 259 59 2 5
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Phase 3 trial for oral cUTI antibiotic stopped early for efficacy

An interim analysis of trial data finds that tebipenem HBr met its primary efficacy end point in patients with complicated urinary tract infections, including pyelonephritis.

www.cidrap.umn.edu/a...

10 months ago 24 8 1 1
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What’s the optimal cefazolin dose for MSSA CNS infections?
New PK/PD data says: it’s not just about higher doses—MIC matters.
2g q6h works only if MIC <=0.5 mg/L
For MIC:1-2 mg/L, continuous infusion (10–12g/day) may be needed to hit PD targets #idsky
journals.asm.org/doi/10.1128/...

11 months ago 35 5 4 0
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Happy ID pharmacist day! I am glad to be an ID pharmacist and collaborate with so many fantastic ID pharmacist! #futureofIDpharmacy
@sidpharm.bsky.social

10 months ago 26 6 0 0
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It’s official. 3 days is the new 5! New #ATS guidelines

11 months ago 7 4 0 0
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The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments Obesity can cause physiological changes resulting in antibiotic pharmacokinetic alterations and suboptimal drug exposures. This systematic review aimed to summarise the available evidence on this topi...

New review

The pharmacokinetics of antibiotics in patients with obesity: a systematic review and consensus guidelines for dose adjustments

www.thelancet.com/journals/lan...

11 months ago 8 6 0 1
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🚨 Ready to improve antibiotic prescribing at your institution? Our Penicillin Allergy Management course empowers providers with the tools and training they need to lead penicillin allergy assessment initiatives.

👉 Register today: bit.ly/3DGu684

11 months ago 3 3 1 0
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You’ve Got a Friend in Me: Curbside Questions Infectious Diseases Clinicians Ask Infectious Diseases Pharmacists

I really can't stress enough just how critical ID pharmacists are in improving patient care

Over 6 months, 10 ID pharmacists were "curbsided" w/ 1,518 Qs, 3/4 from ID attendings

89% of answers led to changes in management!!!

@erinmccreary.bsky.social @sidpharm.bsky.social
#IDSky #PharmSky

11 months ago 95 25 4 2
This photograph captures Sir David Attenborough seated outdoors on the rugged terrain of Skomer Island. Behind him, the ocean and coastal cliffs form a scenic backdrop under a clear sky. Sir David, dressed in a khaki jacket and light trousers, looks towards the camera with a gentle expression, exuding a sense of warmth, calm, and wisdom. Around him, puffins can be seen flying and perched on the rocky ground, illuminated in rays of golden sunlight as the sun sets behind the cliffs.

This photograph captures Sir David Attenborough seated outdoors on the rugged terrain of Skomer Island. Behind him, the ocean and coastal cliffs form a scenic backdrop under a clear sky. Sir David, dressed in a khaki jacket and light trousers, looks towards the camera with a gentle expression, exuding a sense of warmth, calm, and wisdom. Around him, puffins can be seen flying and perched on the rocky ground, illuminated in rays of golden sunlight as the sun sets behind the cliffs.

Happy 99th birthday to the man who gave voice to the wild. 🎉

Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.

You've inspired generations to fall in love with nature.

11 months ago 43127 7955 651 475
Visual abstract for state-of-the-art review on nocardiosis

Visual abstract for state-of-the-art review on nocardiosis

State-of-the-Art Review:

Modern Approach to #Nocardiosis —Diagnosis, Management, and Uncertainties

@zyetmar.bsky.social and colleagues

#IDSky #TxID @cidjournal.bsky.social

academic.oup.com/cid/article/...

11 months ago 20 6 0 0
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State-of-the-Art Review: Recurrent Uncomplicated Urinary Tract Infections in Women Abstract. Over 50% of adult women experience at least 1 urinary tract infection (UTI) in their lifetime, and almost one-quarter of them will experience a r

One of the most challenging encounters in the outpatient practice of infectious diseases, summarized here wonderfully in @cidjournal.bsky.social by Drs. Advani and colleagues.
Have already used this algorithm several times!
doi.org/10.1093/cid/...

11 months ago 42 12 3 1
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🙍‍♀️ w/Staph aureus BSI have high rates of mortality & metastatic infx (Think ❤️,🫁,🦴, & 🔩!). Huge shout out to these authors for succinctly summarizing A LOT of complex data! Truly a huge 🏋️‍♂️

👀 Figure 2 & Table 2

doi.org/10.1001/jama.2025.4288

#IDSky #rxsky #pharmsky #AMSsky #medsky #SIDP

11 months ago 16 8 0 0
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Antibiotic prophylaxis in injury: an American Association for the Surgery of Trauma Critical Care Committee clinical consensus document

A super useful set guidelines for abx prophylaxis in trauma that came out last year which I missed:

pmc.ncbi.nlm.nih.gov/articles/PMC...

Written by trauma surgeons with many common injuries that DON’T require ppx or alternatively ppx <48 hours

#IDSky

11 months ago 21 5 2 0
Non-beta-haemolytic streptococcal bacteraemia in patients with heart valve prosthesis – is it always infective endocarditis? AbstractIntroductionNon-beta-haemolytic streptococci are among the most common causative agents of infective endocarditis (IE). Patients with a heart valve prosthesis (HVP) have a high risk of IE. We aimed to determine the risk for IE in patients with HVP and non-beta-haemolytic streptococcal bacteraemia (NBHSB), and to study NBHSB relapse depending on treatment duration.MethodAdults with HVP and NBHSB 2015—2018 in the region of Skåne, Sweden, were identified through the Clinical Microbiology Laboratory in Lund and were evaluated in a population-based investigation. Data were collected from medical records according to a pre-defined protocol.ResultsA total of 110 NBHSB episodes in 89 patients with HVP were included. In 40 episodes (36%), the patients had definite IE, in 69 possible IE, and one had rejected IE according to the European Society of Cardiology 2015 criteria. Twenty-eight of the 70 patients (40%) without a definite diagnosis of IE were treated with antibiotics as if they had IE. There were seven NBHSB relapses, and six of these occurred in patients with possible IE. Four of the relapses occurred in patients who received antibiotics for less than 14 days. Three patients with possible IE were diagnosed with definite IE at the time of the relapse.ConclusionPatients with NBHSB and HVP have a high risk for IE and should be thoroughly investigated. Most patients with NBHSB and HVP who fulfilled criteria for possible IE did not receive long-course antibiotic treatment. Moreover, some patients treated with a short course of antibiotics experienced NBHSB relapse.

In a study of 89 patients with heart valve prosthesis (HVP) and non-beta-haemolytic streptococcal bacteraemia (NBHSB), 36% had definite infective endocarditis (IE). 40% of those without definite IE were treated as if they had it. 7 relapses occurred, mostly in patients treated <14 days. 🩺💉

#idsky

1 year ago 2 2 0 0
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"Can I stop vancomycin based on this negative MRSA nares?" What does the nose know?👃

Here are 5 things to consider when interpreting MRSA nares swab results. Check it out here ➡️ www.idstewardship.com/5-things-kno...

@idstewardship.bsky.social

1 year ago 5 2 0 0
Frequency of Antibiotic Overtreatment and Associated Harms in Patients Presenting With Suspected Sepsis to the Emergency Department: A Retrospective Cohort Study Treatment guidelines recommend rapidly treating all patients with suspected sepsis with broad-spectrum antibiotics. This may contribute to antibiotic overuse. We quantified the incidence of antibiotic overtreatment and possible antibiotic-associated harms among patients with suspected sepsis.MethodsWe reviewed the medical records of 600 adults treated for suspected sepsis with anti–methicillin-resistant Staphylococcus aureus and/or antipseudomonal β-lactam antibiotics in the emergency departments of 7 hospitals, 2019–2022, to assess their post hoc likelihood of infection, whether narrower antibiotics would have sufficed in retrospect, and possible antibiotic-associated complications. We used generalized estimating equations to assess associations between likelihood of infection and hospital mortality.ResultsOf 600 patients, 411 (68.5%) had definite (48.0%) or probable (20.5%) bacterial infection and 189 (31.5%) had possible but less likely (18.3%) or definitely no (13.2%) bacterial infection. Among patients with definite/probable bacterial infection, 325 of 411 (79.1%) received antibiotics that were overly broad in retrospect. Potential antibiotic-associated complications developed in 104 of 600 (17.3%) patients within 90 days, most commonly new infection or colonization with organisms resistant to first-line agents (48/600 [8.0%]). Mortality was higher for patients with less likely/definitely no bacterial infection versus definite/probable bacterial infections (9.0% vs 4.9%; adjusted odds ratio [aOR], 2.25 [95% confidence interval{CI}, 1.70–2.98]), but antibiotic-associated complication rates were similar (14.8% vs 18.5%; aOR, 0.79 [95% CI, .60–1.05]).ConclusionsAmong 600 patients treated with broad-spectrum antibiotics for possible sepsis, 1 in 3 most likely did not have a bacterial infection, 4 in 5 of those with bacterial infections were treated with regimens that were broader than necessary in retrospect, and 1 in 6 developed antibiotic-associated complications.

📊 In a study of 600 suspected sepsis patients, 31.5% had no bacterial infection. 79.1% of those with infections received overly broad antibiotics. 17.3% faced complications. 🏥

#idsky

1 year ago 2 2 1 0
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Blujepa (gepotidacin) approved by US FDA for treatment of uncomplicated urinary tract infections (uUTIs) in female adults and paediatric patients 12 years of age and older | GSK Blujepa is the first in a new class of oral antibiotics for uUTIs in nearly 30 years.

🔥Breaking news🔥
US FDA approved Blujepa (gepotidacin) for treatment of uncomplicated urinary tract infections (uUTIs) in female adults and paediatric patients 12 years of age and older
#IDsky #utisky #medsky #AMSsky
www.gsk.com/en-gb/media/...

1 year ago 21 12 1 5

Welcome!!! Indeed, glad you're here and yes, it's on🤗

1 year ago 1 0 0 0
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"The greatest use of life is to spend it for something that will outlast it". William James

1 year ago 0 0 0 0
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In memory of the Black Mamba and those who were lost on this day 5 years ago...his legacy lives on...

1 year ago 3 0 1 0
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Five years ago, we lost a legend.

Mamba Forever 💛💜

1 year ago 4780 679 94 144
Massive stars in our Milky Way Galaxy live spectacular lives. Collapsing from vast cosmic clouds, their nuclear furnaces ignite and create heavy elements in their cores. After only a few million years for the most massive stars, the enriched material is blasted back into interstellar space where star formation can begin anew. The expanding debris cloud known as Cassiopeia A is an example of this final phase of the stellar life cycle. Light from the supernova explosion that created this remnant would have been first seen in planet Earth's sky about 350 years ago, although it took that light 11,000 years to reach us. This sharp NIRCam image from the James Webb Space Telescope shows the still hot filaments and knots in the supernova remnant. The whitish, smoke-like outer shell of the expanding blast wave is about 20 light-years across. A series of light echoes from the massive star's cataclysmic explosion are also identified in Webb's detailed images of the surrounding interstellar medium.

Massive stars in our Milky Way Galaxy live spectacular lives. Collapsing from vast cosmic clouds, their nuclear furnaces ignite and create heavy elements in their cores. After only a few million years for the most massive stars, the enriched material is blasted back into interstellar space where star formation can begin anew. The expanding debris cloud known as Cassiopeia A is an example of this final phase of the stellar life cycle. Light from the supernova explosion that created this remnant would have been first seen in planet Earth's sky about 350 years ago, although it took that light 11,000 years to reach us. This sharp NIRCam image from the James Webb Space Telescope shows the still hot filaments and knots in the supernova remnant. The whitish, smoke-like outer shell of the expanding blast wave is about 20 light-years across. A series of light echoes from the massive star's cataclysmic explosion are also identified in Webb's detailed images of the surrounding interstellar medium.

🔭 Supernova Remnant Cassiopeia A

Image Credit: NASA, ESA, CSA, STScI; D. Milisavljevic (Purdue University), T. Temim (Princeton University), I. De Looze (University of Gent)

apod.nasa.gov/apod/ap25011...

1 year ago 178 50 3 6