✨ New in IntAct✨
We’ve integrated the GPCR–RAMP interactome from Sakmar lab’s study 🧬🔬
🔗 www.ebi.ac.uk/intact/searc...
🔹 215 GPCRs tested
🔹 122 show strong RAMP interactions
🔹 23 endogenous GPCR–RAMP complexes identified
🔹 Fully curated dataset ready for analysis
#GPCR #Interactome
👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct!
#IntActEBI #PPI #NetworkBiology
👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct!
#IntActEBI #PPI #NetworkBiology
📌 Each interaction includes 𝐛𝐢𝐧𝐝𝐢𝐧𝐠 𝐚𝐟𝐟𝐢𝐧𝐢𝐭𝐲 (𝐊𝐝), so you can see not just if proteins interact, but how strongly.
🚀 Enabling better network biology, pathway modeling, variant interpretation & drug discovery.
Freely accessible via IntAct: tinyurl.com/2u86jtv5
🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭!
Quantitative fragmentomics data (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.
👏 A big thanks to Élodie Monsellier
@emonsellier.bsky.social
and the team for their collaboration in bringing this integration to IntAct!
#IntActEBI #PPI #NetworkBiology
🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭!
𝐐𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐟𝐫𝐚𝐠𝐦𝐞𝐧𝐭𝐨𝐦𝐢𝐜𝐬 𝐝𝐚𝐭𝐚 (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.
IntAct release 252 is out! 1,787,152 binary interactions from 23,889 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_04)
👏 Huge thanks to UniProt for integrating the isoform information!
🤝 This was a joint curation effort by IntAct and UniProt, and a great example of collaborative science.
Here’s to an exciting year ahead! 🚀🧬
tinyurl.com/N-terminal-p...
#EMBLEBI #IntActEBI #UniProt #Proteoforms
👏 Huge thanks to UniProt for integrating the isoform information!
🤝 This was a joint curation effort by IntAct and UniProt, and a great example of collaborative science.
Here’s to an exciting year ahead! 🚀🧬
tinyurl.com/N-terminal-p...
#EMBLEBI #IntActEBI #UniProt #Proteoforms
Study beautifully demonstrates how N-terminal proteoforms can reshape protein interactomes - gaining new interactions and/or losing others compared to their canonical counterparts - highlighting the power of proteoform diversity in cellular networks.
🎉✨ Happy 2026! ✨🎉
We’re excited to kick off the year by sharing the integration of the work “N-terminal proteoforms may engage in different protein complexes” from the Kris Gevaert lab (VIB, Ghent, Belgium) 🎓🔬
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology:
“AI is showing how vital data curation really is.”
www.ebi.ac.uk/about/news/p...
🖥️🧬
Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including:
UniProt
Complex Portal @complexportal.bsky.social
Gene Ontology @geneontology.bsky.social
IntAct @intact-ebi.bsky.social
InterPro @interprodb.bsky.social
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin
🎨IntAct Cytoscape visualisation:
Candida albicans ECE1 peptides (orange) and their human protein targets (blue)
#IntActEBI #Interactome #EMBL
Maps the interactome of all eight Candida albicans ECE1 propeptides and their specific human protein targets, revealing both unique and shared host interactions that provide new insights into fungal–host communication.
✨🧬New on IntAct! ✨
Interaction data from the study
📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉
Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable.
#Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters
📥 Submit your data here:
🔹 IntAct: tinyurl.com/zzrcx742
Want your PPI or structural data to make an impact?
✅ Use Identifierss
✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713)
✅ Submit to EMBL-EBI's data resources - IntAct
👉 See Niri’s dataset in IntAct:
tinyurl.com/yp8ddheh
Don’t just publish - be found! 🔍
I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511.
🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details!
#Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem