New preprint 🥳

Gamma secretase isnt a single enzyme, multiple GSEC exist depending on which subunits are incorporated into the complex. We made PSEN1 & PSEN2 knockouts to study the impact of different GSEC in neurons & microglia

Led by @celarber.bsky.social

www.biorxiv.org/content/10.6...

Integrative genomic and functional analyses reveal NINL as a modulator of tau aggregation INTRODUCTION Proteostasis dysfunction is a hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD), yet the genetic and molecular pathways that disrupt protein homeostasis remain poor...

Excited to share new work led by Sam Swift in the lab identifying NINL as a modifier of tau seeding

A pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia - Nature Communications Researchers show that a disease-causing Tau mutation disrupts the autophagy-lysosome pathway in human neurons, leading to Tau accumulation, and that enhancing autophagy can partially restore protein c...

Beyond excited to share new work using super resolution microscopy to reveal how a tau mutation drives early changes in the autophagy lysosome pathway led by the amazing Dr Mirfakhar

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-i...

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration - Nature Neuroscience ALS/FTD-linked mutations in UBQLN2, a protein quality control factor, impair degradation of enzymes essential for mitochondrial lipid catabolism, leading to metabolic dysfunction and neurodegeneration...

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration
www.nature.com/articles/s41...

Transgender rights = human rights.

In many countries around the world, the rights of trans people are under attack.

This International Transgender Day of Visibility, we continue to work for a world where all people can enjoy their rights fully.

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

Guidelines for T cell nomenclature - Nature Reviews Immunology This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...

Guidelines for T cell nomenclature www.nature.com/articles/s41...

Newly discovered RNA molecule could limit protein aggregation and prevent neuronal damage Neurodegenerative diseases, such as Alzheimer's disease and dementia, are medical conditions that entail the progressive loss of neurons and a decline in brain function. Past studies have found a link...

medicalxpress.com/news/2025-11...

"[c]learly Rosy had to go or be put in her place”

NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...

Our first Family Social Hour is today at 8PM! Join us to meet other #MAPTFTD families ❤️

#cureMAPTFTD #FTD

us06web.zoom.us/meeting/regi...

#EndAlz

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia.

Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs.

Alzforum
www.alzforum.org/news/researc...

Preprint
www.biorxiv.org/content/10.1...

Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau - Molecular Psychiatry Molecular Psychiatry - Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau

Excited to share new work from the lab showing that FTD causing mutations in tau cause widespread defects in microglia function
www.nature.com/articles/s41...

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

🎉🎉🎉🎉🎉🎉🎉

Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?

Contrary to Clear, Verifiable Facts, Secretary Kennedy Continues to Repeat Harmful Myths About Alzheimer’s and Dementia Research The Alzheimer's Association calls on HHS Secretary Kennedy to stop dangerous fabrications about the state of Alzheimer’s and dementia research.

www.alz.org/news/2025/ke...

Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @ukdri.ac.uk @uclqsion.bsky.social - pls help circulate among networks who’d be of interest, thank you!

LipidCruncher: An open-source web application for processing, visualizing, and analyzing lipidomic data

Everyone should contact their us congress members and tell them not to cut SNAP (food stamps). secure.everyaction.com/lmBv70YdQkCu...

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

Could blocking ‘jumping genes’ help fight disease and aging? The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own

Great article featuring pioneering work from the Frost lab along with promising clinical trial data @bessfrost.bsky.social

Join us on Monday, April 21st for our next #ZoomYourCareer webinar, "The Future of #AI in Research “Is #ChatGPT Smarter than Me?” with #CCAD alumni speakers Shea Andrews and @trajnp.bsky.social!

Registration 🔗 us02web.zoom.us/meeting/regi...

#NewVisionResearch #ProfessionalDevelopment

Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting. Welcome! You are invited to join a meeting: The Future of AI in Research “Is ChatGPT Smarter than Me?”. After registering, you will receive a confirmation email about joining the meeting.

Zoom your career 🤓🧠🧬us02web.zoom.us/meeting/register/tIp9vIu...