Now with video!
youtu.be/4op2z7X6y4U

Ketamine, the Cognitive Enhancer - Talking Ketamine Podcast Can a drug famous for making people "space out" actually be used to rebuild lost memories and reverse cognitive decline?

Can a drug that makes you "space out" actually repair brain damage? 🧠⚡️

Ep 59 explores a 2026 review on ketamine as a cognitive enhancer.
🧯 The "Fire Extinguisher": Stopping toxic excitotoxicity.
🌱 The "Fertilizer": Rebuilding neural pathways (BDNF).

🎧

#Ketamine #Neurology

Now with video: youtu.be/YsM_0qkHNPY

Ketamine and Joy - Talking Ketamine Podcast Does ketamine just numb the pain of depression, or can it actually regrow the brain's physical capacity to feel pleasure?

Are standard antidepressants turning down the volume on your joy?

Ep 58 explores "emotional blunting" vs. ketamine's ability to structurally repair the brain's reward circuits.
** The Engine & The Steering Wheel
** fMRI proof of returning pleasure

🎧

#Ketamine #Neuroscience

Now with video!
youtu.be/4t0QqPgo-uQ

Ketamine's Brainwave Fingerprint - Talking Ketamine Podcast Does a psychiatric medication actually need to alter your consciousness to rewire your brain or is the "trip" part of the healing?

Big Pharma tried to engineer the "trip" out of ketamine... and accidentally removed the cure.

Ep 57 explores the "Gamma-Delta Shift."
Gamma waves = the "forest fire" (the trip).
Delta waves = the structural regrowth.

You can't have the repair without the fire.
🎧

#Ketamine #Neuroscience

Now with video: youtu.be/33MdYNL4iOY

Ketamine's Child - Talking Ketamine Podcast What if the therapeutic "high" from oral ketamine isn't actually caused by ketamine, but by a hidden metabolite manufactured by your liver?

What if your ketamine pill isn't actually ketamine by the time it hits your brain? 💊🧠

Ep 56 explores the "liver tollbooth" and how a hidden metabolite drives the therapeutic high. Why oral dosing needs a major math upgrade.
🎧 talkingketamine.com/ketamines-ch...

#Ketamine #Pharmacology

Now with video.
youtu.be/X1tlY_MG5-Q

Ketamine's Bipolar Balancing Act - Talking Ketamine Podcast Explore how ketamine's bipolar targeting offers rapid relief without waking the "manic bear." Does treating bipolar depression mean mania?

Treating bipolar depression is a trap: standard meds can trigger severe mania. 🎢

Ep 55 explores how ketamine & esketamine change the game:
📉 Rapid relief in hours.
🛑 ZERO manic switches in real-world data.
🧠 Targeting anhedonia.
🎧

#Ketamine #Bipolar

Ketamine Proof of Consciousness - Talking Ketamine Podcast Does anesthesia turn your brain off, or does it simply paralyze your body and erase your memory? Ketamine shows that consciousness persists.

Does anesthesia actually turn your brain off? 🧠💤

Ep 54 explores a terrifying 2026 paper:
🔇 The "Broken Speaker": Paralysis isn't unconsciousness.
🖐️ The Isolated Forearm Technique.
🌀 How ketamine proves the mind expands when the body shuts down.

🎧 #Neuroscience #Ketamine #Anesthesia #Consciousness

The Nine Year Odyssey YouTube video by Talking Ketamine Podcast

Why does ketamine stop working? It might be your liver. 📉💊

Ep 52 reviews 9 years of ketamine research including "Auto-induction": how the body learns to eat the drug before it reaches your brain.

Now with video:
📺 youtu.be/NVObfq0o0gI

#Ketamine #Pharmacology #MentalHealth #Science

The Nine Year Odyssey - Talking Ketamine Podcast We explore a massive doctoral thesis mapping the risks of oral ketamine, liver tolerance, and the shift to neuroplasticity.

Why does ketamine stop working? It might be your liver. 📉💊

Ep 52 reviews 9 years of research on ketamine including how the body learns to eat the drug before it reaches your brain.

Also, Ketamine "softens the clay," but you have to sculpt it.

#Ketamine #Pharmacology #MentalHealth #Science

The Nasal Spray Wars - Talking Ketamine Podcast FDA-approved Spravato vs. generic ketamine: A new 2026 study pits the expensive "heavyweight" against the $42 challenger

Spravato ($$$) vs. Generic Ketamine ($)

A 2026 study compares the FDA-approved giant vs. the compounded generic.
📉 Symptom relief? Identical.
✅ Result: Generic is "non-inferior."
💸 The main difference is the price tag.

Ep 51: Why "new" ≠ "improved."

#Ketamine #MentalHealth

Credit for the amazing research goes to the authors that are on BlueSky: @rgsheld.bsky.social @yousufakhan.bsky.social @nchanaday.bsky.social @martinadamenti.bsky.social @golgiwhillikers.bsky.social Thank you!

Check out our podcast about the book. bsky.app/profile/talk...

Ketamine and the Nanoscopic World - Talking Ketamine Podcast From "chemical soup" to high-definition precision. Ep 50 zooms in on the molecular architecture of the synapse and how ketamine repairs it.

Ketamine goes nanoscopic!

Forget the "chemical soup", the synapse is a high-precision machine.
- The "Nanocolumn"
- The "Ghost" signal that ketamine fixes
- How your brain uses "liquid physics" to heal
It's all in Episode 50

#Ketamine #Neuroscience #MentalHealth

Ketamine and Diabetes – The Metabolic Tightrope - Talking Ketamine Podcast Ketamine tackles pain and depression, but is it safe for your blood sugar? We explore the metabolic tightrope.

Ketamine & Diabetes: A metabolic tightrope?

It targets the pain/depression "syndemic", but risks are high: Blood sugar spikes & drops; Liver "traffic jams"; Metformin interference?

We explore precision Ketamine dosing in Ep 48.

#Ketamine #Diabetes

The Patient's Voice - Talking Ketamine Podcast What does ketamine feel like? A new review reveals patients often value human connection as much as the drug.

What does ketamine therapy actually feel like?

We move beyond symptom scores to the "Patient's Voice." We explore the "Rollercoaster" of the trip, why staff support is 50% of the cure, and the grief of the crash.

#Ketamine #MentalHealth #PatientExperience #Depression

The Science of Dissociation - Talking Ketamine Podcast Does healing require a "trip"? New research shows how ketamine-induced dissociation disrupts the Default Mode Network to rewire the brain.

Is the "trip" the cure? 😵‍💫

A 2025 review suggests dissociation isn't a side effect—it's key to breaking depressive loops.

We explore the "Science of Dissociation" & why chaos in the brain helps.

#Ketamine #Neuroscience #MentalHealth

Ketamine Reimagined – Reset Button or Relational Tool? - Talking Ketamine Podcast For decades, ketamine has been viewed primarily through two lenses: a safe anesthetic or a rapid-acting antidepressant "reset button." But a new paper by Sophie Holland argues we may be missing half t...

Is ketamine a "reset button" or a "relational tool"?

Ep 45 explores how DOSE defines the therapy: High Dose: Rapid "Psychedelic" reset & ego dissolution. Low Dose: "Psycholytic" safety & deep relational work.

talkingketamine.com/ketamine-rei...

#Ketamine #MentalHealth #Psychedelics

Ketamine and Sickle Cell Disease - Timing is Everything - Talking Ketamine Podcast Sickle Cell Disease (SCD) pain crises are the leading cause of hospitalization for affected children, causing excruciating vaso-occlusive episodes where misshapen blood cells block oxygen flow to tiss...

New study on 74,000 admissions: Early ketamine for kids with Sickle Cell Disease pain crises cut hospital stays in HALF (12 days ➡️ 6 days). 📉

Why is adoption still so low? We break down the data and the barriers.

🎧 talkingketamine.com/ketamine-and...

#SickleCell #Ketamine #PainMgmt

Will Ketamine Work for Me? - Talking Ketamine Podcast "Will this actually work for me?" It is the most critical question patients ask before investing time, money, and hope into ketamine therapy. In this episode, we analyze a massive body of research—inc...

"Will ketamine work for me?" 🤔

We analyzed a thesis of 112 studies: ❌ Age, sex & trauma don't predict results. ✅ A tiny 4.1% symptom drop after dose 2 signaled 100% success.

Full breakdown in Ep 43 🎧 talkingketamine.com/will-ketamin...

#Ketamine #MentalHealth #Depression