Congrats(?)!!

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity pubmed.ncbi.nlm.nih.gov/41950284/ #cryoEM

Van Gogh Starry night is hypnotising... but this hits on a different level...

The low-density lipoprotein receptor LDLR mediates cellular entry of nonenveloped hepatitis A virus pubmed.ncbi.nlm.nih.gov/41894341/ #cryoEM

You are on a roll @olibclarke.bsky.social !

This video was a complete joy to make. Here's a short preview, but next time you're looking to sit down for 45 minutes of math and art, take a look at the full version on YouTube: youtu.be/ldxFjLJ3rVY

🚨 Preprint alert!

We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs
#CryoEM #RNABiology

A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors

🔗 doi.org/10.64898/202...
(0/7🧵)

Stoic 🦾 from our shared student @daniil-litvinov.bsky.social predicts protein complex stoichiometry. A fun collab with @ninjani.bsky.social @torstenschwede.bsky.social - this #AI adventure beyond our core #CryoET methods was made possible by the @biozentrum.unibas.ch PhD Fellowship Program! 🧪 🧶🧬

Oh Gosh! Sorry for not replying earlier! It seems the venue isnt the same as before… schaade!

HOpe to be able to attend the meeting next year! Kloster-Schontal was to several legendary retreats and workshops and I would love to relive those times at some point in the near future!

Did you see this post think “Oh damn! I have this really cool story but not enough time to submit!”. Well we heard you! And extended the deadline to 30.03.2026! Send your abstracts in for a chance to present in Autumn!

If you have computational and physics chops go work with @bforsb.bsky.social . You will mot be disappointed!

Figure 1. Cryo-EM of abundant protein complexes in native membranes.

Figure 2. Cryo-EM of membrane proteins in vesicles.

Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes.

Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.

I've written a review on what I think is an extremely exciting direction in cryo-EM:

Cryo-EM of endogenous membrane proteins in their native lipid bilayer

Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...

I fucking hate proline so fucking much it's the worst amino acid it's so fucking stupid it's incapable of being fucking normal so it forms an ugly ass ring with itself with its own fucking nitrogen cuz it's a loser fucking amino acid I hate it so much I'd rather cut off my right tit than have to ever draw a mechanism with proline ever again

Remember that everyone you meet is fighting their own battle, sometimes with amino acids

Abstract submission closes this Friday. If you have a story to tell and have just seen this do apply! @dbhella.bsky.social and myself look forward to your abstracts!

The deadline for applying to the open postdoc position in our lab is coming up!

Reach out if you have questions about the project, our lab and ISTA!

ALS Untangled® ALSUntangled® reviews alternative and off label treatments, with the goal of helping people with ALS make more informed decisions about them.

2/5
When you have ALS, you experiment. Supplements, drugs, hope. See alsuntangled.com for why that's so common.
So I built ALSTracker. It won't give you certainty. But it replaces gut feeling with something more solid: Bayesian statistics.
alstracker.mpi-dortmund.mpg.dee

A Geometry of Music: Harmony and Counterpoint in the Extended Common Practice share.google/bbZ6TAVmgIir...
This book has been on my reading list for some time now

Crazy! I had similar experience with a moving company (AnyVan) last year which took an ~50% cut of the fees. Pure evil!

Tired of drawing cilia or centrioles for slides and papers? I feel you.

Check out CiliaBuilder for ChimeraX → cxtoolshed.rbvi.ucsf.edu/apps/chimera...

Build custom 3D cilia & centriole models (tips + primary cilia included).

New preprint by @alok-bharadwaj.bsky.social explaining the workings of SURFER, a simple tool to segment membrane, micelle or nanodisc densities in cryoEM maps.

Try it via the @chimerax.ucsf.edu ToolShed:

cxtoolshed.rbvi.ucsf.edu/apps/chimera...

Despite LocScale in the name, it works on any map.

I agree, I have been fortunate to not have to deal with Windows for the last 13 yrs. But the ubiquity of its Office suite means one is forced to use it because everyone around you uses it or it is foisted upon you by orgs.

XZ Utils backdoor - Wikipedia

Your point brings this recent (last year) to mind en.wikipedia.org/wiki/XZ_Util...
Atleast because of Linux being OSS, the community could detect and patch the exploit.

I cannot see how @microsoft.com can classify its tools as productivity tools. Teams is by far the worst thing on the planet and I DO NOT underestand how organisations including Universities and Governments have bought into this system whole-heartedly!

Trimbody with rigid AI-designed scaffolds enables atomic-resolution cryo-EM structure determination of small proteins pubmed.ncbi.nlm.nih.gov/41735342/ #cryoEM

Just installed and twiddled a few knobs, but I am already impressed with `himena relion`. Amazing job @liu-hanjin.bsky.social! Would be great if this could be made into a default interface for relion.

Proteomic Signatures of Treatment Response During Pulmonary Exacerbations in Cystic Fibrosis at University of Liverpool on FindAPhD.com PhD Project - Proteomic Signatures of Treatment Response During Pulmonary Exacerbations in Cystic Fibrosis at University of Liverpool, listed on FindAPhD.com

Funded PhD studentship (UK students only) available on clinical proteomics, application deadline 22nd March for Oct 2026 start!

This project seeks to understand treatment responses to exacerbations experienced by people with CF using proteomics.

www.findaphd.com/phds/project...

Fantastic design idea to not make it a webapp!

Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...

Amazing Thorsten! Let us know if there’s a way for us as community to come together and help you!