Ich glaube es nicht!
Aus einer besorgniserregenden Studie über steigende Zahlen von Hitzetoten und Tagen mit Extremhitze durch den Klimawandel macht ARD/tagesschau:
„Pollensaison wird länger und stärker“
🤦♂️
👆 I came here to say this.
We are recruiting a post-doc to study olfactory processing and decision-making in rodents, combining quantitative behavior with neurophysiology.
www.oist.jp/careers/post...
Please share with interested colleagues and trainees 🙏
Don't be shy to take on a little two-week side project. These five months will be the most precious three years of your academic journey.
The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.
How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!
Out today in Nature: rdcu.be/fdC2A
@uclbrainscience.bsky.social
Figure 2. FORCE1s reports in vivo neuronal activity with high fidelity under resonance scanning 2-photon microscopy (A-I) 2P-guided whole-cell patching and resonant-scan imaging in anesthetized mice. (A) Experimental schematic. (B) 2P images of a representative FORCE1s-Kv-expressing neuron are shown at high resolution (i) and the size and resolution used during voltage imaging (ii). The patching pipette is outlined. (C) Simultaneous electrophysiological recording (top, 10 kHz) and FORCE1s-Kv fluorescence imaging (bottom, 440 Hz). The fluorescence trace was low-pass filtered at 150 Hz to enhance the visualization of the spikes. Dashed boxes: epochs shown in panels D-E. Vertical lines: detected spikes. Gray triangle (left, and in panels D-E): -70 mV. (D-E) Zoomed-in subthreshold (D) and bursting (E) epochs. Panel D’s optical trace was low-pass filtered at 50 Hz to enhance the visualization of subthreshold fluctuations.
This is beautiful data. 2p optical reporting of subthreshold voltage, validated with simultaneous patch clamp. www.biorxiv.org/content/10.6... FORCE1s by François St-Pierre's group, with a bunch of great people joining in.
I'm not joking when I say mRNA technology is more important than "AI" and it's a tragedy we're throwing billions into one while our government is aggressively defunding the other.
New post, on the value of prospective predictions when it comes to our ability to judge AI:
kucharski.substack.com/p/are-you-ov...
Happy #FluorescenceFriday!
Thank you Georg! Very happy to have worked on this.
Here is a short 🧵 on what ECT-triggered CSD looks like, and why we think it is going to help shape the future of ECT research.
(1/12)
Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...
For nearly a century, we believed the therapeutic effect of ECT is the seizure. Our latest research suggests we may have been looking at the wrong event.
A thread on why cortical spreading depression (CSD) might be the driver of therapeutic benefit.
Work led by @therehugolad.bsky.social
📢 #CancerNeuroscience Online Seminar with Ofer Yizhar, from Weizmann Institute of Science, Israel.
Title: “Optogenetic modulation of neural circuits”
This virtual seminar takes place on April 28, from 5-6 PM CEST, please register here: us06web.zoom.us/meeting/regi...
This week, the #VirtualPub is in collaboration with the Image Data Community Days! We welcome Carsen Stringer, HHMI Janelia, for a talk on "Cellpose-SAM: superhuman generalisation for cellular segmentation." @hhmi-science.bsky.social
🗓️ Fri, April 17 @ 1 pm CEST
www.eurobioimaging.eu/our-events/t...
If you ever wanted to do FLIM, this may be a helpful read
Want to image the activities of many thousands of neurons over an 8mm diameter field of view, in behaving mice? Read our new paper, just published in Light: Science & Applications.
Yang et al, Ultra-wide-field, deep, adaptive two-photon microscopy for multi-scale neuronal imaging. rdcu.be/fc57b
Today’s lectures on live cell imaging and fluorescent proteins by @jencwaters.bsky.social and @talley.codes
Every photon counts!
Designer indicators for two-photon recording of subthreshold voltage dynamics www.biorxiv.org/content/10.64898/2026.04...
Designer indicators for two-photon recording of subthreshold voltage dynamics - BiorXiv
Laser scanning on your equipment entails tradeoffs between speed, resolution, and field-of-view. Pick 2 of those 3.
Now you can get all 3, with this breakthrough.
www.laserfocusworld.com/optics/artic... Thanks @laserfocusworld.bsky.social
www.nature.com/articles/s41...
Two-author papers are always special.
Using optogenetic stimulation of hippocampal synapses in awake mice and tracking them over approx. 2 weeks, we link synaptic strength, spine volume and their stability. It's confirmed: bigger spines are stronger and more stable 😅
Did you see us in Stockholm, Sweden for the Focus on Microscopy (FOM) Conference?
It was great connecting with a diverse community of educators, researchers, and emerging microscopists, all dedicated to advancing microscopy research and fostering collaboration across academia and industry. 🤜🤛
🚨New preprint and our results are rather concerning..
We find the "boiling frog" equivalent of AI use. Using large-scale RCTs, we provide *casual* evidence that AI assistance reduces persistence and hurts independent performance.
And these effects emerge after just 10–15 minutes of AI use!
1/
A photo of a computer screen. The top part shows a blurry microscopy image, with a bright spot in the center surrounded by a red bounding box. The bottom half shows a graph of a cholinergic interneuron, spiking in a rhythmic, bursting fashion.
Someone order a cholinergic interneuron? Look at that beauty!
Sure, in vivo voltage imaging is a bugger, but when it works... 😍
We're hiring!
Research Assistant position in our lab @champalimaudf.bsky.social in #Lisbon. Work on #diet - #brain and #microbiome - #metabolism projects using innovative #microscopy, #connectome and #metabolism methods. Start in May. Apply: ribeirolab.org
European Adaptive Optics Summer School - 13-17 July 2026. Registration is now open:
sites.google.com/view/europea...
I remember a time when personal responsibility was one of the core tenets of conservatism. I may have imagined that, it seems.
Ich finde die gesellschaftliche Stille zu einem 20-Jährigen Rechtsextremen, der gegenüber Medien einen Mordanschlag angekündigt haben soll und anschließend mit Messer und detonierenden Sprengsätzen durch einen ICE zieht, nicht nur befremdlich, sondern extrem beunruhigend. #Siegburg
