Mitotic microhomology-mediated break-induced replication promotes chromoanasynthesis - Nature Communications Chromoanasynthesis is an elusive form of complex chromosomal rearrangement commonly detected in cancer and congenital disorder. Here, the authors develop a long-read DNA sequencing approach and show t...

Excited to share our new paper in @NatureComms!
Using #nanopore sequencing, we uncover how mitotic microhomology-mediated break-induced replication #MMBIR can generate #chromoanasynthesis / complex genome rearrangements linked to cancer and congenital disorders.
www.nature.com/articles/s41...

www.biorxiv.org/content/10.6...