Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort.
www.biorxiv.org/cgi/content/...
Happy to share our Current Opinion review on the key challenges in accurately predicting 3D distances between chromatin segments and computing their dynamics. Thanks to @djost-physbiol.bsky.social @lucagiorgetti.bsky.social for the invitation to write this review! @shuvadipdutta.bsky.social
Thanks for highlighting our work on combining AI-based organelle dynamics detection in phase contrast with fluorescence!
www.nature.com/ncomms/edito...
@natcomms.nature.com and Nelio Rodriguez. Spearheaded by @wl-stepp.bsky.social with collaborators @jclandoni.bsky.social @maweigert.bsky.social
How short can a degron be?
A compact, genetically encoded, 9-aa tunable degron that drives MDM2-dependent degradation enabling precise control of protein levels from yeast to human cells.
Thanks to @eswarappalab.bsky.social for the opportunity to explore this in yeast.
#Degron #Yeast #CellBiology 🧬
Interested in tunable protein degradation? Check out our new preprint describing a compact, portable degron derived from MTCH2: doi.org/10.64898/202...
Led by Lekha EM
Saubhik Som
Ramon Boro
Sandeep Eswarappa
Great collaboration w/ Anubhav Dhar
Eepsitha
@syncellbiolab.bsky.social
#iiscbangalore
I’m honored to be part of the next GRS Single Molecule Approaches to Biology, thanks Chairs @qmsmith.bsky.social and Alba Gomez Segalas for organizing this great event! The GRS is a wonderful opportunity for young scientists to share their exciting science and build communities. See you there!
We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...
Excited to share a new preprint from a team of researchers I am part of (funded by an NIH grant). The paper helps us understand a question I have been interested in for a while: why are bacteria so resilient?
www.biorxiv.org/content/10.1...
@meyerroc.bsky.social
@juliebiteenlab.bsky.social
Wonderful news. Well deserved honor, Cees!
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!
Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
Thank you for having me here, Mike. Big thanks to all the organizers. It was fantastic meeting. Looking forward to the next editions of #SMLMS2025
📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Beautiful. Congrats Luciano!
Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
And the story is published now!🍾
www.nature.com/articles/s41...
Open access link: rdcu.be/exnOc
Many years in the making, great collaboration with @archaellum.bsky.social & @tunglejic.bsky.social
Thanks @ukri.org BBSRC & @leverhulme.ac.uk for funding, reviewers & editor!! 🙏
#microsky #archaeasky
Very much looking forward for #SMLMS2025
🔬 Are you working with single-molecule super-resolution methods (SMLM, MINFLUX) and would like to meet experts in the field and discuss your work? 👉🏻 consider attending the SMLMS 2025 Meeting in Bonn 👉🏻 abstract submission is open until June 27th 👉🏻 www.smlms.org @smlm-symposium.bsky.social
Such fantastic news! I had the privilege of working with Cees — an incredibly inspiring scientist. His research truly deserves this recognition. Huge congratulations, Cees!
Big congrats, Cees. Richly deserved. 👏👏🥳🥳
Happy to share Asha Joseph and Inchara Adhikashreni's latest work from the lab, describing replisome speed variation in Caulobacter!
www.cell.com/current-biol...
Latest #CDlab paper online in @labonachip.rsc.org: pubs.rsc.org/en/content/a...
Here, 1st authors Alex Joesaar & Martin Holub developed a microfluidics platform to extract and study full length megabase-size genomes in microfluidic chambers (where they are protected against shearing by flow)!
Hey #chemsky and beyond, with all that is going on, I am curious what expensive, high margin molecules we could provide to the community for free. What things do you use all the time, cost way too much, and would make a difference? Alexa Fluor 488 NHS? Other dyes? Other molecule?
In @molecularmicro.bsky.social: two special issues on Prokaryotic Chromosome Organization. Many excellent contributions, including a vision article: 'Future directions of the Prokaryotic Chromosome Field', outcome of BioPhyChrom 2023 @biophychrom.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬
The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy
www.biorxiv.org/content/10.1...
The kindest of gentle reminders. We have one week to go on one #PhDPosition and one #PostdocPosition in single-molecule dielectrophoresis. Do you like single molecules , advanced optics and nanotechnology? More details in the thread👇 Dear Bluesky poplulation, please help with reposting
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells www.biorxiv.org/content/10.1...
▶️40-fold flanking sequence effect on TF binding
▶️Motif recognition beats kinetics
▶️Minutes-long residence times
▶️Models of TF-nucleosome competiton
😅 really cool!!!
This is a fantastic community to be part of. Don’t miss the chance!
Amazing!
