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Posts by Seth Coffelt

ScienceDirect.com | Science, health and medical journals, full text articles and books.

📣We've summarized all there is to know about mouse #gdTcells in cancer and how they relate to humans
@immunowolf.bsky.social #AbhiramMallu #NataliePhinney
check it out here:
authors.elsevier.com/sd/article/S...

3 weeks ago 6 3 1 0
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We spend under $50 billion a year on NIH…

1 month ago 40 10 0 0

Check out this lineup 🎉

Join us the last week of June for 100% cancer immunology

1 month ago 11 3 0 0
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Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection γδIELs are essential for intestinal homeostasis, but how their differentiation and cytotoxic function are regulated remains unclear. Xie et al. demonstrate two functionally distinct γδIEL subsets, CD160+TCF1+BCL6+ stem-like and GZMB+BLIMP1+ effector-like cells, and show that Salmonella infection promotes IL-12/TCR-STAT4-BLIMP1 signaling to drive effector differentiation and cytotoxicity, linking γδIEL responses to microbial-derived cues for protective gut immunity.
1 month ago 2 1 0 0
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The people — and research — lost in the NIH exodus | CNN Sylvia Chou, 51

Portraits of some of the researchers that The Regime has run off.

We are losing so many excellent researchers.

1 month ago 120 43 4 1
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Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model In lung cancer, airway macrophages are modulated by an unconventional T cell subset, relevant to care for pulmonary comorbidities.

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model

#gdTcells @coffeltlab.bsky.social

1 month ago 3 2 0 0
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*Recruiting new group leaders*

The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.

1 month ago 13 14 2 0

Check out this lineup 🎉

Join us the last week of June for 100% cancer immunology

1 month ago 11 3 0 0
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Detection of metastatic burden is a task for CODA, which maps organs in 3D and at single-cell resolution.

More here: www.biorxiv.org/content/10.6...

1 month ago 17 2 0 0
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Join us for our March #GDTcellclub webinar talks with Drs. Judith Wienke (Utrecht) and Monika Wolkers (Sanguine BSF) on March 19 at 12pm NY time.

Zoom ID: 958 9051 7066/ passcode 369081

nyulangone.zoom.us/j/9589051706...

2 months ago 14 4 0 2
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UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social

But please more focus on 2 things...

1) Immediate effects (eg funding decisions expected in March)

2) Likely disproportionate effects on early career scientists

www.bbc.co.uk/news/article...

2 months ago 23 15 0 3
Top of the photo in white text reads: "BREAKING OVER 680 NATIONAL ACADEMY OF SCIENCES MEMBERS, INCLUDING 10 NOBEL PRIZE LAUREATES, ENDORSE IMPEACHING RFK JR." Below that in black text is a statement reading: "We, the undersigned Members of the National Academy of Medicine, the National Academy of Sciences, and the National Academy of Engineering, writing in our private capacities, endorse the Articles of Impeachment introduced in the House of Representatives on Dec 10, 2025 by Representative Haley Stevens." Below that is the red "STAND UP FOR SCIENCE " logo. Below that is a link in white text reading: "standupforscience.net/impeach-rfkjr".

Top of the photo in white text reads: "BREAKING OVER 680 NATIONAL ACADEMY OF SCIENCES MEMBERS, INCLUDING 10 NOBEL PRIZE LAUREATES, ENDORSE IMPEACHING RFK JR." Below that in black text is a statement reading: "We, the undersigned Members of the National Academy of Medicine, the National Academy of Sciences, and the National Academy of Engineering, writing in our private capacities, endorse the Articles of Impeachment introduced in the House of Representatives on Dec 10, 2025 by Representative Haley Stevens." Below that is the red "STAND UP FOR SCIENCE " logo. Below that is a link in white text reading: "standupforscience.net/impeach-rfkjr".

BREAKING: Over 680 members of the National Academy of Sciences, Medicine, and Engineering have endorsed articles of impeachment against RFK Jr.
(1/2 🧵)

2 months ago 6509 2161 69 94
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US science after a year of Trump: what has been lost and what remains A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce.

More than 7,800 research grants terminated or frozen. Some 25,000 scientists and personnel gone from agencies. Proposed budget cuts of 35% — amounting to US$32 billion.

These are just a few of the ways Donald Trump has downsized and disrupted US science
go.nature.com/4sTPWdp

2 months ago 124 85 6 10

Climate change news

The three seasons in the UK are now Easter, summer and Christmas.

3 months ago 7 2 1 0

Yikes I’ll start doing some pushups 🤓

3 months ago 3 0 0 0
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📢Are you a talented #ECR looking to start your independent lab in state-of-the-art cancer research facilities?

Join the CRUK Scotland Institute & @uofgcancersciences.bsky.social as a Junior Group Leader!

👉Apply here: www.crukscotlandinstitute.ac.uk/careers/grou...

📅Closing date: 10 October 2025

7 months ago 15 10 1 0
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UK study visa applications drop as immigration changes hit universities Fees from international students are vital in offsetting long-term funding squeeze

Was
"Let's make our universities financially dependent on overseas tuition fees."

Then
"Let's make it more difficult and less attractive for overseas students to come to the UK."

Now
"Oops."

7 months ago 51 23 2 1

Super proud to see our work featured on the cover of @emboreports.org today. Many thanks to @pedromics.bsky.social for this beautiful interpretation and depiction of our story. Read the associated paper here: www.embopress.org/doi/full/10....

7 months ago 5 2 0 0
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γδT cells and breast cancer: wicked allies Metastatic disease and therapy resistance pose significant challenges in the treatment of breast cancer. Recent studies by Rozalén et al. and Petroni …

check out our new commentary on 2 recently published papers about #gdTcells in breast cancer
www.sciencedirect.com/science/arti...

7 months ago 15 3 2 0
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No one has done more damage to public health and trust in science and medicine than Andrew Wakefield.

26 years after his wrong and fraudulent paper people are still spouting his nonsense about an alleged link between vaccines and autism.

The study was debunked countless times.

There is no link.

7 months ago 126 65 4 2

Let’s do the experiment and find out

7 months ago 1 0 0 0
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MO Gov Mike Kehoe is calling a special session to gerrymander the 5th District which encompasses Kansas City.

He is specifically violating Section 2 of the Voting Rights Act, which bans any voting practice that denies or weakens the power of a racial minority to elect its preferred candidates.

7 months ago 6037 2656 209 95
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Tackling TNBC recurrence with gdT cell immunotherapies What makes gdT cells unique in their ability to tackle TNBC recurrence? Read our latest opinion piece to find out

www.oncology-central.com/tackling-tnb...

8 months ago 8 0 3 0
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Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved!

www.embopress.org/doi/full/10....

8 months ago 1 1 1 0

The Junior PI call @ccii-kyoto.bsky.social is open until the end of the month.
Join us in Kyoto! 👇
#Immunology #Immunotherapy #Immunosky

9 months ago 4 4 0 1
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ICYMI: In pancreatic cancer even localized disease poses a threat to long-term survival due to early metastasis.

@brianpedro.bsky.social & Laura D. Wood @jhu.edu review the most common PDAC precursors and highlight opportunities for pancreatic precancer interception.

buff.ly/xQ0ediG

9 months ago 3 3 0 0
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💥 Check out our latest review article just out @cp-trendscancer.bsky.social @cellpress.bsky.social

doi.org/10.1016/j.tr...

In this paper, we carefully review multiple aspects that tightly link #platelets to #metastasis

9 months ago 7 2 1 0
Video

When the reviewers' identities are revealed

9 months ago 206 21 6 1

Congrats 🎉

9 months ago 1 0 0 0
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Search jobs for external candidates | Jobs | Imperial College London

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

9 months ago 17 13 1 0