Sulfur fluoride exchange with carbon pronucleophiles Aryl alkyl sulfones are an important class of compounds in drug discovery; thus, new methods toward their synthesis are desirable. A general sulfur fluoride exchange (SuFEx) method to couple aryl sulf...

SuFEx welcomes new coupling partners - carbon pronucleophiles now in @chemicalscience.rsc.org . Congrats to Ball Lab students Joe Novicku and Matt Teeter and Pfizer colleagues Alistair, Tom, Neil, ans @chrisamende.bsky.social on the great work! #MyFirstChemSci

pubs.rsc.org/en/content/a...

Just completed a three-month sabbatical Groton, CT site with @chrisamende.bsky.social . I had a great time working with excellent colleagues (including @bagphos.bsky.social ) and learning a lot of new chemistry. Thanks so much!

@ballnchemist.bsky.social it was amazing to have you here in Groton! Looking forward to sharing some of the great chemistry explored with everyone soon :)

Senior Scientist, Chemical Biology and Proteomics Would you like to discover the medicines of the future? At Pfizer we deliver Breakthroughs That Change Patients Lives. In the Chemical Biology and Proteomics group, we play a vital role in this missio...

Opportunity in chemical biology & #proteomics at Pfizer (Groton CT USA) ref: 4924293 | closing: 06-Dec-2024 #ChemBiol #biochem #chemsky 🧪
pfizer.wd1.myworkdayjobs.com/PfizerCareer...

Lewis Acid-Catalyzed Sulfur Fluoride Exchange A new method uses metal Lewis acids as catalysts to convert sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides with silyl amines into S–N bond-containing compounds via sulfur fluoride exchange. The reaction successfully employs Ca(NTf2)2 as a catalyst to form sulfonamides, sulfamates, and sulfamides using in situ-generated or commercially available silyl amines in 35–99% yields. Other metal Lewis acids are also demonstrated to be catalysts in SuFEx, forming sulfonamides and sulfamates in yields comparable to those of Ca(NTf2)2.

Check out the latest from our lab's
@theballlab in @JOC_OL Lewis Acid-Catalyzed Sulfur Fluoride Exchange.

pubs.acs.org/doi/10.1021/...

Chemical Biology of Nucleic Acids Join me for this event: Chemical Biology of Nucleic Acids

Exciting NYAS symposium on the Chemical Biology of Nucleic Acids happening on January 14th, with an awesome speaker lineup from academia and industry. Submit an abstract if you want to present a poster or potentially get selected for a short talk! bit.nyas.org/4furecg