Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing - Nature Biotechnology A large screen of approved kinase inhibitors expands the druggable kinome.

Comprehensive profiling of clinically approved kinase inhibitors reveals mutation-specific inhibitors and opportunities for drug repurposing - @fredhutch.org go.nature.com/4904pMC

Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2 - Nature Biotechnology FAMSA2 accurately aligns millions of protein sequences at high speed.

10 years after the first FAMSA paper, its successor is now published in Nat Biotech! We believe that FAMSA2 can enable analyses of large protein collections that were previously unattainable. Thank you, Andrzej and Cedric, for great collaboration
www.nature.com/articles/s41...

Minimal life by computer
Progress toward a true virtual cell will depend on uniting AI’s pattern-finding power with the causal rigor of mechanistic models go.nature.com/48muYvd

The April issue is live www.nature.com/nbt/volumes/...

On the cover: Ishiguro et al. describe CloneSelect, which uses barcode-specific CRISPR base editing to activate a reporter gene, enabling precise isolation of individual clones from complex cell populations retrospectively go.nature.com/4ksLOMD

Research Briefing: An inducible base editing platform for cancer functional genomics in vivo www.nature.com/articles/s41...

Engineered hematopoietic stem cells generate B cell precursors that expand through immunization to produce therapeutic antibodies in mice #NBThighlight www.science.org/doi/10.1126/...

Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments - Nature Biotechnology Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.

Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments go.nature.com/48bpVhg

Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology Diversity-generating retroelements are engineered for directed evolution in E.coli.

Diversity-generating retroelements for programmable targeted hypermutagenesis - @dbikard.bsky.social @institutpasteur.bsky.social go.nature.com/3OG2nKN

Cell-type-targeted mitochondrial transplantation rescues cell degeneration - Nature MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.

The mitochondrion-targeting tool MitoCatch brings mitochondria into specific cell types through cell-surface-targeted binders #NBThighlight www.nature.com/articles/s41...

Artificial allosteric protein switches with machine-learning-designed receptors - Nature Biotechnology Allosteric biosensors are constructed by combining reporter proteins with machine-learning-designed receptor domains.

Artificial allosteric protein switches with machine-learning-designed receptors - @arccoesb.bsky.social go.nature.com/4cshpM3

Inducible, split base editors for in vivo cancer functional genomics - Nature Biotechnology Inducible base editors enhance cancer genomic screens in vivo.

Inducible, split base editors for in vivo cancer functional genomics - @junweishi.bsky.social go.nature.com/4tfu1xi

Structure-centric searching enables global mapping of the public metabolome - Nature Biotechnology StructureMASST enables pan-repository MS/MS searches using a chemical name or structure.

Structure-centric searching enables global mapping of the public metabolome - @pieterdorrestein.bsky.social @mingxunwang.bsky.social @yelabiead.bsky.social go.nature.com/481Sbmk

Scientists uncover new method to generate protein datasets for training AI #NBTintheNews news.rice.edu/news/2026/sc...

Breakthrough Protein Sequencing Tech Unlocks Cellular Secrets - Stanford Today A team of bioengineers at Stanford University has unveiled a groundbreaking method to visualize proteins by converting them back into DNA sequences, allowing researchers to leverage existing DNA seque...

Breakthrough protein sequencing tech unlocks cellular secrets #NBTintheNews nationaltoday.com/us/ca/stanfo...

Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2 - Nature Biotechnology FAMSA2 accurately aligns millions of protein sequences at high speed.

Fast and accurate multiple-protein-sequence alignment at scale with FAMSA2 - @sdeorowicz.bsky.social
go.nature.com/4muAQsh

By integrating career programming into their funding strategies, philanthropies can serve as catalysts for change, providing resources and training that institutions may struggle to offer consistently go.nature.com/4lXKHq5
rdcu.be/fdeC8

Quantifying endosomal escape in vivo to guide lipid nanoparticle design - Nature Biotechnology A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.

A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery #NBTNV go.nature.com/4s4X7P7
rdcu.be/fdfzQ

Innovation and policy challenges of AI–drug hybrids - Nature Biotechnology Patent applications indicate a trend toward completely integrating artificial intelligence (AI) with drugs, whereby AI applications will be so tightly linked to drugs that the drugs could be effective...

Patent applications indicate a trend toward completely integrating artificial intelligence with drugs, whereby AI applications will be so tightly linked to drugs that the drugs could be effectively unusable without the AI go.nature.com/41u0p2R
rdcu.be/fdeyM

close up of plant leaf

Out recently in @natbiotech.nature.com — first authors
@ddingding.bsky.social and @evangroover.bsky.social premier a cell-based method for understanding how #photosynthesis genes can be turned "up" or "down". Read here: ow.ly/KHWg50YyWbR

For Nature Biotechnology's 30th anniversary, we asked a selection of faculty about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications go.nature.com/4rSBl0g
rdcu.be/fcEox

Most of the world’s diseases have been forgotten by commercial drug development. Patient advocacy groups must look to new types of partnerships to develop therapies go.nature.com/4d8aDx3
rdcu.be/fcEmY

Balenciaga debuts eight-legged yarns - Nature Biotechnology Nature Biotechnology - Balenciaga debuts eight-legged yarns

AMSilk, one of a cluster of biotechs to produce bioengineered spider yarn, launched its first textile product with Italian fashion giant Balenciaga, who used the biodegradable silk to make a shirt and shirtdress from the environmentally friendly thread www.nature.com/articles/s41...
rdcu.be/fcCgt

Esophagus engineering tackles function #NBTNV go.nature.com/4mtXYXN

AI-enabled vascular grafts monitor blood flow - Nature Biotechnology Engineered blood vessels harness artificial intelligence (AI) and magnetoelasticity to continuously monitor blood flow and stenosis in real time.

Engineered blood vessels harness artificial intelligence and magnetoelasticity to continuously monitor blood flow and stenosis in real time #NBTNV go.nature.com/4rOPo7z
rdcu.be/e3F7s

A programmable DNA drug system targets cancer cells with extreme precision Self-activating DNA system to fight cancer.

A programmable DNA drug system targets cancer cells with extreme precision #NBTintheNews www.techexplorist.com/programmable...

Sequence Display enables large-scale sequence–activity datasets for rapid protein evolution - Nature Biotechnology Sequence Display maps protein variant activities to a sequencing-based readout.

Sequence Display enables large-scale sequence–activity datasets for rapid protein evolution go.nature.com/4siazyJ

First orexin agonists address root cause of narcolepsy - Nature Biotechnology A new class of agents is poised to transform treatment for people with narcolepsy by mimicking missing orexin peptides.

First orexin agonists address root cause of narcolepsy www.nature.com/articles/s41...
[🔓read free with login]

Chemigenetic kinase biosensors illuminate cell signaling networks - Nature Biotechnology Red-shifted chemigenetic biosensors enable sensitive, multiplexed detection of intracellular signaling in living cells across various subcellular compartments and microscopy setups.

Red-shifted chemigenetic biosensors enable sensitive, multiplexed detection of intracellular signaling in living cells across various subcellular compartments and microscopy setups #NBTNV go.nature.com/3GGYUHj
rdcu.be/fb9UC

In Conversation with Haijiao Liu, PhD Liu spoke with Lindsey Leake about the implications of this work, the challenges inherent to tumor-on-a-chip studies, and his plans to launch a lab of his own this fall.

In conversation with Haijiao Liu, PhD #NBTintheNews www.insideprecisionmedicine.com/topics/oncol...

Minimal life by computer go.nature.com/48muYvd