Great work led by Dr Ken Hoffman on the CICM second part exam vivas www.sciencedirect.com/science/arti...

RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Casey. NEJM. 2025. doi: 10.1056/NEJMoa2511420 Clinical Question Among adults with non‑traumatic critical illness undergoing emerg...

RSI: Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults – The Bottom Line #foamed #foamcc

www.thebottomline.org.uk/summaries/ic...

Etomidate Pharmacology of etomidate (Critical Care Compendium entry)

Etomidate • LITFL Critical Care Compendium #foamed #foamcc

Comprehensive overview of etomidate pharmacology for critical care clinicians including implications from the RSI trial

litfl.com/etomidate/

Pity they massively overdosed the ketamine arm - significant percentage > 2mg/kg / no ceiling dose ("rule of 1 ampoule") / dose per total body weight / and who gives > 0.5 mg/kg to a "sick" patient - great trial / wrong pharmacology / wrong conclusion = drugs are equivalent at equipotent doses

The Worlds Best Intensive Care Meeting is up and running -
Critical Care Reviews Down Under - triallist, editorialist, statistician, expert panel - an hour - not 10 mins - and that is the outside behind them - Naarm (Melbourne)

Co-Chief Investigators Jonathan Casey and Matthew Semler share their insights from the #RSI trial after presenting at #CCRdownunder

Livestream -> www.criticalcarereviews.com

@jama.com

CCR Down Under 2025 Original Article | Dec. 9, 2025 | NEJM.org Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Figure 1. In-Hospital Death, According to Trial Group. The NEJM identity sits at the bottom.

In a randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. Full trial results: nej.md/44EOlxB

@criticalcarereviews.com

Chief Investigator Arthur Kwizera shares an overview of the #ARISEAFRICA trial after presenting at #CCRdownunder and highlights what clinicians can take away from the results.

Livestream -> www.criticalcarereviews.com

@jama.com

Co-Chief Investigators Brenda O'Neill and Danny McAuley share the results of the #iRehab trial after presenting at #CCRdownunder

Livestream -> www.criticalcarereviews.com

@jama.com

The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting #### Summary points

#ARISEAFRICAtrial is a stepped wedge cluster- this design is useful for interventions delivered at the ICU/hospital level and individual randomisation is difficult. Clusters transition from control to intervention at different times www.bmj.com/content/350/... #ccrdownunder @criticalcarereviews.com

RSI trial now starting

➡️ Etomidate vs Ketamine for RSI

➡️ Jonathan Casey & Matthew Semler presenting
➡️ Chris Nickson editorialising

➡️ Join the livestream - criticalcarereviews.com

#ccrdownunder

Congratulations to the RSI trial team #CCRdownunder

Wow wow wow

Beautiful trial. Nice editorial. Worth watching if you intubate patients.

JAMA article "Precision Therapy for Sepsis The End of the Beginning?" by Derek C. Angus, MD, MPH. Article discusses sepsis treatment, host response, and clinical trials.

Editorial by JAMA Senior Editor Derek Angus: The ImmunoSep RCT demonstrates the feasibility of biomarker-guided treatment, while highlighting ongoing challenges in immune classification and broader clinical application. #CCRdownunder ja.ma/3Kg3qz3

Second at #ccrdownunder - #IREHABtrial
Post your questions at #ccrdownunder and #IREHABtrial or at the livestream: criticalcarereviews.com

Precision Therapy for Sepsis Sepsis is a macabre dance between host and pathogen.1 With development of germ theory by Lister, Semmelweis, Pasteur, and Koch, pathogen eradication was the focus. Only in recent decades, with observa...

Precision Therapy for Sepsis: The End of the Beginning? | Critical Care Medicine | JAMA | JAMA Network #ccrdownunder 2025
jamanetwork.com/journals/jam...

JAMA graph titled 'Figure 2. Primary End Point'. 'Change from the baseline SOFA score' is plotted for precision immunotherapy (orange) and placebo (blue). SOFA scores range from 0 to 20; x-axis is 1 to 145.

RCT: Among patients with #sepsis, a precision immunotherapy strategy targeting macrophage activation-like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo.#CCRdownunder ja.ma/3MkSb95

JAMA research summary on precision immunotherapy to improve sepsis outcomes.The trial assessed whether immunotherapy could improve organ function in sepsis-3 patients.35.1% in precision immunotherapy vs 17.9% in placebo groups.

📊 Research Summary: The ImmunoSep trial demonstrates the potential for biomarker-guided immunotherapy in a subset of patients with sepsis. #CCRdownunder ja.ma/4pMi8wt

ImmunoSep uses a double-dummy design.
What is this? It is a design to maintain blinding when 2 treatments can't be made identical- all participants receive 2 treatments- one which is active and the other which is placebo #ccrdownunder

Precision Immunotherapy to Improve Sepsis Outcomes This randomized trial assesses whether precision immunotherapy tailored to macrophage activation–like syndrome or sepsis-induced immunoparalysis improved organ dysfunction compared with placebo among ...

IMMUNOSEP trial - JAMA jamanetwork.com/journals/jam... #ccrdownunder 2025

Looking forward to #ccrdownunder- if you are following along please include this hashtag in any posts and I can moderate your questions online- enjoy the live!!!

Up first at #ccrdownunder - #IMMUNOSEPtrial
Post your questions at #ccrdownunder and #IMMUNOSEPtrial or at the livestream: criticalcarereviews.com

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There are now just under 50 days to CCR Down Under 2025.

The programme is out - 8 superb trial results coming up.

Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world!

criticalcarereviews.com/meetings/ccr...

CCR Down Under 2025 Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 9th - 10th, 2025

The 5th trial to be announced for CCR Down Under 2025 is ACTiVE

Effect of automated closed-loop ventilation versus conventional ventilation on duration and quality of ventilation in critically ill patients

Join us in Melbourne, either in-person or online
criticalcarereviews.com/meetings/ccr...

CCR Down Under 2025 Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 9th - 10th, 2025

CCR Down Under 2025 - december 9th & 10th 2025 Melbourne is the place to be! Registrations are open 😁: criticalcarereviews.com/meetings/ccr... See you there! @criticalcarereviews.com

CCR Down Under 2025 Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 9th - 10th, 2025

🚩The 3rd trial result for CCR Down Under 2025 is ARISE-AFRICA🚩

➡️Standard low flow oxygen vs nasal high flow oxygen vs CPAP in hypoxaemic respiratory failure

➡️Presenter Arthur Kwizera

➡️Join us in Melbourne
criticalcarereviews.com/meetings/ccr...

@precordialthump.bsky.social

CCR Down Under 2025 Critical Care Reviews Meeting Down Under - The Edge, Federation Square, Melbourne, December 9th - 10th, 2025

CCR Down Under 2025 - december 9th & 10th 2025 Melbourne is the place to be! Registrations are open 😁: criticalcarereviews.com/meetings/ccr... See you there! @criticalcarereviews.com

Looking forward to this!