Dear proteomics aficionados,

The famous MaxQuant Summer School is organized again July 21–25, 2025, but spots are filling up!

Join the team of Jurgen Cox for hands-on training in MaxQuant, register here:
www.eventbrite.de/e/maxquant-s...

Best regards,
Jürgen Cox, Albert Heck & Pavel Sinitcyn

In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer Nature Communications - While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for...

Just out by Shelley Jager: rdcu.be/edEnO. One of the fastest & deepest plasma glycoproteomics studies. Take home message; we even detect glycosylated cytokines and chemokines, but also still need better software. #glycotime @utrechtuniversity.bsky.social @bijvoet-centre.bsky.social

A glycan foldamer that uses carbohydrate–aromatic interactions to perform catalysis - Nature Chemistry In nature, catalysis is generally performed by proteins and ribozymes. Now it has been shown that glycans can be designed to perform catalysis. Exploiting carbohydrate–aromatic interactions, a glycan ...

@carolynbertozzi.bskyverified.social is this a first glycan catalyst? Sialyl Lewis X as a catalyst for Pictet-Spengler
www.nature.com/articles/s41...

Take some pond wanter and discover these cool looking glycofibrils!
www.pnas.org/doi/abs/10.1...
#glycotime

Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity Qiu et al. identify that reduced mannose metabolism is a key characteristic of T cell dysfunction. Enhancing mannose metabolism in T cells through D-mannose supplementation boosts anti-tumor activity, limits exhaustion differentiation, and maintains T cell stemness. Mechanistically, D-mannose promotes the OGT-mediated O-GlcNAcylation and stabilization of β-catenin, enhancing T cell stemness.

Mannose supplementation appears to be a gift that just keeps giving #glycotime

www.cell.com/cancer-cell/...

Bioanalysis Rising Star Award: an interview with the 2024 winner In this interview with the 2024 BRSA winner, Tomislav discusses the work that led to his nomination and advice for future nominees.

Happy to share my attempt in explaining my work and shout out for #Glycotime.
www.bioanalysis-zone.com/videos/bioan...

Photo dump from a great time last week at EBF Barcelona. Grateful for the opportunity to share our #glycotime efforts!

Bioanalysis Rising Star Award 2024 Learn more about the 2024 Bioanalysis Rising Star Award winner, the finalists and the nominees.

www.bioanalysis-zone.com/bioanalysis-...

Happy to share the good news! Officially received the award this week at EBF Barcelona. I am on a mission to convince more people about the promises of #glycotime in immuno-oncology. Please hit me with your favorite examples of #glycotime in cancer.

Could it be possible to make a gif or something? Would love to use this in intro slides!

Fumbled through the interview, but slipped at least 6 #glycotime
mentions

Arrived at European Bioanalysis Symposium. 3 days of talks, should we keep count of (if any) times #glycotime takes the stage?

Hey 🦋! We at MIT BE @mitdeptofbe.bsky.social are searching for a tenure-track faculty colleague at the interface of #immunology and #biologicalengineering. Still plenty of time to apply before our priority deadline on 12/1, more details here: tinyurl.com/2p8hs6hu.
Please share widely!

It has been a life saver. Having the ability to model glycans detected by our analytical approaches and showcase them on a relevant protein structures to biologist colleagues with no glyco or MS experience really helps to push the message through on potential functional implications!

Glycosylation: mechanisms, biological functions and clinical implications - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Glycosylation: mechanisms, biological functions and clinical implications

My first #glycotime post here is going to be calling this out:
www.nature.com/articles/s41...

How does this pass the peer review of what is a supposedly prestigious journal?