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Posts by Jonathan C. Lau

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Earlier this week, we hosted Dr. Bob Gross from Rutgers as the 2025 Blume-Girvin lecturer speaking on LITT for #epilepsy. A privilege to have Dr. Parrent in attendance whose pioneering work w/ Blume helped motivate the development of LITT. Two great mentors.
@westernu.ca @lhsccanada.bsky.social

4 months ago 4 1 0 0
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HippoMaps: multiscale cartography of human hippocampal organization - Nature Methods HippoMaps provides an open-source resource for studying the human hippocampus at different scales and with different modalities such as histology, fMRI, structural MRI and EEG.

HippoMaps: an open-source resource for studying the human hippocampus at different scales and with different modalities.
www.nature.com/articles/s41...
@jordandekraker.bsky.social @borismontreal.bsky.social @jclauneuro.bsky.social @neuroak.bsky.social @sofievalk.bsky.social @donnagift.bsky.social

6 months ago 26 11 0 0
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So proud of @alaat.bsky.social for successfully defending his thesis. First PhD grad of the AIMS lab! 🎯

Incredibly fortunate to work with him & @neuroak.bsky.social on AFIDs project.

Thanks also to examiners DrEmmaDuerden DrSarahMattonen @angelarobertsphd.bsky.social @emiddlebrooksmd.bsky.social πŸ™

9 months ago 7 1 0 0
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Standing room only for @emiddlebrooksmd.bsky.social talk on Clinical Applications of 7T -- a special summer grand rounds
@WesternU CNS!

Incredible work @mayoclinic.org integrating 7T.

Thanks for the visit, and examining @alaat.bsky.social's thesis!

9 months ago 4 0 1 0
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Tuesday July 22, Dr. Erik H. Middlebrooks from the @mayoclinic.org will be giving a seminar entitled "Clinical Applications of 7T MRI in Neuroimaging" at University Hospital.

9 months ago 6 6 0 1

@cfmm.bsky.social speakers from @westernu.ca at the 7T Translational Alliance of North America meeting in Dallas, hosted by UTSW.

9 months ago 5 2 0 0
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Honoured to give the keynote at the 7T Translational Alliance of North America meeting in Dallas this morning recognizing @cfmm.bsky.social leadership in 7T human imaging. We continue to be the only πŸ‡¨πŸ‡¦ site at this meeting. @westernuresearch.bsky.social @westernu.ca

9 months ago 15 2 1 0
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Alert!!!!

β€œAn Action Networks Model for Pain”

We propose a new model for chronic pain β€” and highlight two functionally connected cortical networks that could revolutionize how we treat it.

πŸ‘‰ thread below 🧡

osf.io/preprints/ps...

9 months ago 91 42 2 7
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Benchmarking methods for mapping functional connectivity in the brain | doi.org/10.1038/s415...

What is the best measure of functional connectivity (FC)?

led by @zhenqi.bsky.social in @natmethods.nature.com ‡️

10 months ago 88 44 4 3
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A Kitchener man is now seizure free following a rare epilepsy treatment at London Health Sciences Centre (LHSC) Neurosurgeon Dr. Jonathan Lau reviews medical scans with his patient Steven Kieffer, who underwent a rare epilepsy procedure called a laser ablation last year.

Incredible story featuring #WIN Executive Committee member @jclauneuro.bsky.social - A Kitchener man is now seizure free following a rare epilepsy treatment at London Health Sciences Centre (LHSC) www.ctvnews.ca/london/artic...

10 months ago 9 5 1 0
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New paper in Imaging Neuroscience by Mohamad Abbass, Jonathan C. Lau, et al:

The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space

doi.org/10.1162/imag...

11 months ago 10 1 0 2
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The impact of localization and registration accuracy on estimates of deep brain stimulation electrode position in stereotactic space Abstract. Effects of deep brain stimulation (DBS) depend on millimetric accuracy and are commonly studied across populations by registering patient scans to a stereotactic space. Multiple factors cont...

Really proud of MohamadAbbass & team for pushing our preprint through to publication in @imagingneurosci.bsky.social! Hopefully the first of many in this journal. doi.org/10.1162/imag...

Appreciate all the supportive feedback about our AFIDs project during the review process.🧠🎯

10 months ago 3 0 0 0

New paper in Imaging Neuroscience by Britta U. Westner, Tim M. Tierney, et al:

Cycling on the Freeway: The perilous state of open-source neuroscience software

doi.org/10.1162/imag...

11 months ago 35 22 0 4
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New paper in Imaging Neuroscience by Elodie Germani, Camille Maumet, et al:

On the validity of fMRI mega-analyses using data processed with different pipelines

doi.org/10.1162/imag...

11 months ago 13 8 0 0

Amazing work through @hbhlmcgill.bsky.social from leading minds in neuroscience including @lisasaksida.bsky.social @mallarchak.bsky.social @maximoprado.bsky.social and Dr. Tom Durcan, also TRIDENT lead researchers! πŸ™ŒπŸŒŽπŸ”¬πŸ

11 months ago 7 2 0 0
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At #HBHLSymposium2025, experts from @mcgill.ca & @westernubrainscan.bsky.social shared their breakthroughs in non-invasive neurostimulation, iPSC models and circuit-based approaches for epilepsy, ALS & more, as part of the McGill-Western ITN. πŸ§ πŸ”¬ @borismontreal.bsky.social @jclauneuro.bsky.social

11 months ago 9 3 0 1

If you have an interest in non-human primate systems neuroscience and/or imaging esp. if it relates to development or learning, call me! These are major chair positions that come with at least $4M or $8M over 8 years, depending on career stage.

11 months ago 33 29 2 0

Western University is seeking applications for Canada Excellence Research Chairs. Please reach out if you are interested in Theme 2: Neuroscience. Western has extraordinary strengths in cognitive, molecular and systems neuroscience across species (rodents, NHPs, humans) uwo.ca/research/cer...

11 months ago 72 57 0 5
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New: Energy use shapes brain organization and development. We use gene expression maps from the @alleninstitute.bsky.social Human Brain Atlas to map the main energy metabolism pathways in the brain. Led by @moohebatpe.bsky.social @misicbata.bsky.social @goliashf.bsky.social and Justine Hansen 🧡

1 year ago 45 20 2 1
Homepage - openRxiv openRxiv is an independent non-profit, the new organizational home for bioRxiv and medRxiv, enabling researchers to instantly share groundbreaking findings with the global scientific community.

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

1 year ago 2561 846 55 42
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Western Postdoctoral Fellowship Program Western University, in vibrant London, Ontario, delivers an academic and student experience second to none.

If you would like to postdoc in ultra high field MRI (3T+7T human, 9.4T+15.2T marmoset and mouse) in a well funded lab with tons of great neuroscience collaborations, drop me a DM soon.

1 year ago 26 20 1 2
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I am excited to announce that I will be founding an institute for network stimulation at the University Hospital Cologne – already this coming May!

1 year ago 157 23 25 5

πŸŽ‰ Lyle Muller, Laura Batterink, and @jclauneuro.bsky.social awarded CIHR funding to study neural traveling waves in sleep spindles as a biological mechanism for memory consolidation. Dreaming big for understanding human memory! πŸ§ πŸ’­ #SleepScience #MemoryConsolidation #CIHR

1 year ago 2 1 0 0

Hope you'll forgive a quick thread as I take over as the new EiC of @elife.bsky.social

1 year ago 153 64 3 7
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Predicting Individual Pain Sensitivity Using a Novel Cortical Biomarker Signature This cohort study analyzes electroencephalography data from healthy participants to analyze and validate a cortical biomarker signature for pain, which comprised the measures sensorimotor peak alpha f...

our NIH HEAL initiative funded biomarkers study now out @jama.com JAMA Neurology

open access, open data and code

w/ @drsmschabrun.bsky.social

jamanetwork.com/journals/jam...

1 year ago 34 15 3 3
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The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow - Nature Neuroscience The default mode network (DMN) is implicated in cognition and behavior. Here, the authors show that the DMN is cytoarchitecturally heterogeneous, it contains regions receptive to input from the sensory cortex and a core relatively insulated from environmental input, and it uniquely balances its output across sensory hierarchies.

Out in @natureneuro.bsky.social today πŸ₯‚

Cytoarchitecture, wiring and signal flow of the human default mode network

Combining 3D histology, 7T MRI, and connectomics to explore DMN structure-function associations

Led by Casey Paquola, @themindwanders.bsky.social & a terrific team of colleagues πŸ™

1 year ago 130 43 8 4
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🚨Interested in Dystonia?🚨
@braincircuits.bsky.social

GPi DBS for dystonia is effective.

More recently, STN DBS has been investigated, as an alternative.

In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks…

www.pnas.org/doi/10.1073/...

1 year ago 50 25 2 5
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The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧡 ⬇️

1 year ago 145 64 4 4
A collage of figures from the 350 papers published in Imaging Neuroscience in 2024.

A collage of figures from the 350 papers published in Imaging Neuroscience in 2024.

2024 was the first full calendar year for Imaging Neuroscience @mitpress - 350 papers published.

We're proud of how the brain imaging community enthusiastically embraced open access non-profit publishing. Our aim is to be *your* journal.

Full size PDF: drive.google.com/file/d/1M170...

1 year ago 114 32 3 8
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How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...

The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes

Thought provoking work my Martin Gell et al:

www.nature.com/articles/s41...

1 year ago 178 77 2 11