Join us at the #EFIS congress for #SexDifferencesInImmunity in Hamburg, #Germany on Oct 8-9th 2026!

📢2nd Annual Meeting of the EFIS-IL Sex Differences in Immunity Study Group!
🗓️October 8-9, 2026
📍Hamburg, Germany
🔗https://linktr.ee/EFIS_ISD
@yefis-immunology.bsky.social @dgfi-org.bsky.social @sfi-immunologie.bsky.social @swimm-immuno.bsky.social @irishimmunology.bsky.social @finnsocimm.bsky.social

thank you so much Darragh :) @darraghduffy.bsky.social

ERC grant awarded to explore how the immune system shapes fertility Lund University. Infertility is a deeply personal and global health issue, affecting one in six adults. Current treatments, however, often focus on symptoms rather than root causes, resulting in pregn...

🌟 Congrats to Assistant Prof. Camila Consiglio (@consigliocr.bsky.social) on being awarded a @erc.europa.eu Starting Grant! She will explore how the immune system shapes fertility and pregnancy outcomes in a new project: fertiliMMUNE.

Read more: www.stemcellcenter.lu.se/article/erc-...

#Immunology

Thank you so much and congrats to other #LS6 #ERCStG awardees!

I'm thrilled to share I’ve been awarded a @erc.europa.eu starting grant! #ERCStG

#fertiliMMUNE will uncover how the immune and reproductive systems communicate, with the aim to improve fertility outcomes.

I'm incredibly thankful to my amazing lab, collaborators, peers & ERC for their support!

We are also super happy with the collaboration Mauricio! Cheers to this excellent work!

Super interesting work on pDC to cDC transition regulated by TNF and type I IFN!

Would be curious to know how biological sex affects this, given our previous findings on masculinizing hormone therapy regulating pDC/IFN-I and TNF www.nature.com/articles/s41...

Decoding sex differences in immunity through systems immunology is an important direction to extend our understanding beyond binary (M vs W) and towards biological mechanisms of immune regulation, which can pave the way for tailored, sex- and gender-informed treatments.

Further studies will be key to answer such questions and improve care for trans people, who are currently underrepresented and underserved in medicine.

This work opens new questions, such as *how* can estrogen therapy shift immune function? Are these changes mediated by direct effects on immune cells or progenitors or via other intermediates? And could such immune shifts impact responses to infection and outcomes?

Very happy that our lab (w/ @resabut.bsky.social leading systems-level analyses) contributed to this important collaborative work!

- Yet, humoral and cellular vaccine responses remained unchanged by estrogen therapy

- RNAseq indicated a shift in immune function towards increased lymphocyte responses (T & NK cells) and decreased innate and myeloid responses (TLR, IFNs, monocytes and neutrophils) during FHT. Interestingly, this remained significant even after immune perturbation with an mRNA vaccine and boost

✨ Highlights
- Exogenous estrogen therapy induced many changes in blood cell counts and chemical profiles, including lower albumin and red blood cells and increased platelet counts

New publication from our collaborative work with @mamartins83.bsky.social!

How does feminizing hormone therapy #FHT impact the immune system?

Exogenous estrogen enhances T cell activation in male primates www.cell.com/cell-reports...

@cp-cellreports.bsky.social

Human monoclonal antibodies targeting A35 protect from death caused by mpox Three potent mAbs against the conserved MPXV A35 protein block viral spread, protect against lethal infection in mice, and align with protective antibody responses in convalescent humans, establishing...

🚨 New article! Our study "Human monoclonal antibodies protect against death caused by mpox" is now published:
👉 www.cell.com/cell/fulltex...
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Decoding sex differences in human immunity through systems immunology Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

‼️Our first review is out‼️

Decoding sex differences in human immunity through systems immunology shorturl.at/EsAkE

We discuss how #SystemsImmunology decodes #SexDifferences in #HumanImmunity, paving the way for tailored, sex-informed treatments.

Excellent work by @resabut.bsky.social & Tianze Cao!

Decoding sex differences in human immunity through systems immunology Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

I'm thrilled to share that my first co-authored review, "Decoding sex differences in human immunity through systems immunology," on Oxford Open Immunology! I'm so grateful for the opportunity to have worked with Tianze Cao and @consigliocr.bsky.social on this. doi.org/10.1093/oxfi...

Cell Line-Specific Estrogen Responses Uncover Functional Sex Differences in Murine Macrophages - PubMed Background RAW 264.7 (male-derived) and J774A.1 (female-derived), are widely used in immunology research, yet their responses to gonadal hormones remain poorly understood. Gonadal hormones, particular...

Even in cell lines, sex matters pubmed.ncbi.nlm.nih.gov/40630528/

A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics Nature Medicine - A large single-cell transcriptomic-based reference model for hematopoietic stem and progenitor cells from 148 age- and sex-diverse individuals identifies physiological and...

🧬🖥️ scAtlas of CD34+ cells from 148 people reveals how circulating hematopoietic stem/progenitor cells (cHSPCs) shift with age, sex & disease. Reference model enables myelodysplastic syndrome (MDS) diagnosis. From great Liran Shlush & Amos Tanay ‪@natmed.nature.com‬: doi.org/10.1038/s415... 🧪

Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections

Not just shingles vaccine, but also RSV vaccine reduces the risk of dementia, which highlights the benefit of revving up the immune system in older individuals
www.nature.com/articles/s41...

Join us for this exciting webinar tomorrow, 24th June 2025 at 14h00 CEST!

@resabut.bsky.social PhD student in my #SystemsImmunology will be speaking ;)

Congrats to Léa Chicosine, postdoc in our group, and @laura-rabanal.bsky.social from @cto-bourgine.bsky.social Lab for best grant submitted to the Wallenberg Center for Molecular Medicine Research School! Excellent work! 🎉

Tianze Cao, PhD student in my #SystemsImmunology lab, had an excellent presentation on how #Metabolic and #Reproductive factors impact the #ImmuneSystem in #PCOS at the #AE_PCOS_Update_Meeting at #ECE2025 @aepcossociety.bsky.social

Exciting collaborative work with @elisabetsv.bsky.social

Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer - Nature Immunology Sexual dimorphism is a feature of many cancers, but how this functions is often unclear. Here the authors show that in bladder cancer it is regulated by a microbiota–lurasidone–LCN2 circuit that contr...

Microbiota-shaped neutrophil senescence regulates sexual dimorphism in bladder cancer
www.nature.com/articles/s41...

Interesting work where Zhu et al demonstrate that gut microbiota regulates sexually dimorphic antitumor immunity and bladder cancer progression

Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation In this article, da Rocha and colleagues show that XCI erosion is frequent yet variable in female human iPSCs, leading to reactivation of some X-linked genes, including escapees. This reactivation is ...

Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation: Stem Cell Reports www.cell.com/stem-cell-re...

Sharing on behalf of my coauthors, delighted to have played a small role in this study

Today is the international day for transgender visibility! Important now than ever when there are significant polical forces limiting freedom for people to be who they are and live their life true to themselves.

@lundstem.bsky.social @lunduniversity.bsky.social @lunduniversity-med.bsky.social @infect-lu.bsky.social 📣Calling all local immunology enthusiasts to sign up for this IRL #LundImmunotalks symposium where we bring leading immunologists from around the world to Lund, Sweden! don't miss lit.blogg.lu.se

Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness Mammary intraepithelial lymphocytes enhance mammary gland differentiation during pregnancy, thereby promoting offspring fitness.

Now available online: our recent work showing that the maternal adaptive immune system promotes optimal lactogenesis. @dancrrl.bsky.social
www.cell.com/cell/fulltex...