Lung basement membranes are compositionally and structurally altered following resolution of influenza infection www.mucosalimmunology.org/article/S193...

(MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester on FindAPhD.com PhD Project - (MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester, listed on FindAPhD.com

📣 PhD project available 📣
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social

www.findaphd.com/phds/project...

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social

WE ARE HIRING! www.manchester.ac.uk/exposome-jobs

Vacancies inc. 3x PDRA positions, 2x data scientists and a Transition Fellowship in Air Pollution.

Join us as we embark on a 14 year journey to understand how the exposome impacts immune regulation and chronic inflammation.

#hiring #immunosky

Tony giving his Rooster Prize talk at HA2025

Congratulations Tony! 👏 @mcrcellmatrix.bsky.social

Finishing off a lovely few days with @dakinlabgroup.bsky.social in Oxford doing some tissue staining 💚 Thanks so much for hosting me Prof Dakin and Yao!

It was a pleasure to write this piece on HPV immunisation as part of our #CelebrateVaccines series 💙 Now more than ever, it is critical that we share evidence based resources on vaccination to help people make informed decisions about their health 🦠💉🌍

Congratulations to Dr Georgia for an amazing viva success and thank you to her enthusiastic examiners.

Still time to apply to join our lab in Aberdeen as a post-doc, in a well-funded position. If you're interested in immune-ECM cross talk and want to use cutting edge spatial technologies, apply now. www.abdnjobs.co.uk/vacancy/rese...

Please spread the word and sign up for our exciting spring meeting in Nottingham with amazing speakers on the topic of ECM, immunity and infection. An exciting and developing field! paacr4.wixsite.com/bsmb-spring2...

2024 has been a fantastic year of lung/imm/mac papers with some critical insights on host/pathogenesis. I'm highlighting some papers that I found in this thread, perhaps we can build more immune niches on sky app with help of @rodrahimi.bsky.social who initiated discovery imm stack. 🧵 x/n. Let's go.

Congratulations @hetompkins.bsky.social so very proud of you 💜💜💜

Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...

Super grateful 💚 for support from my supervisors @drtesutherland.bsky.social @profjudiallen.bsky.social and Tony Day. Excited that we can continue to answer questions about immuno-matrix interactions in lung health thanks to support from @wellcometrust.bsky.social watch this space....

Parasite models have taught us so much about how the immune response is regulated - we think they can also teach us a lot about immune-mediated matrix formation and it's roles in effective (or not!) tissue repair

Mice that lack #IL-13 have a reduced type-2 response and we found they have less #HA at day 7 post infection... But IL-13 deficient mice have more tissue damage - highlighting an important IL-13-HA-tissue repair pathway that were investigating further 👀

The peak of HA in the lung coincides with the peak of the #type2immune response - which we know to be essential for effective #repair of the tissue damage caused by the parasite 🪱

Injury From Nematode Lung Migration Induces an IL‐13‐Dependent Hyaluronan Matrix A consistent feature of lung injury is a rapid and sustained accumulation of hyaluronan (HA). The rodent gut-dwelling nematode Nippostrongylus brasiliensis (Nb) induces tissue damage as it migrates t....

🎉 the 1st paper from my post-doc is published 🎉 We found that #lunginjury caused by migration of N.brasiliensis induces an #IL-13 dependent #hyaluronan matrix. onlinelibrary.wiley.com/doi/full/10....

Really interesting angle, and one we don't yet have the answer too. Certainly a possibility - CD44 binding to HA is highly dependent on how the HA is 'presented' to it. We've got lots more questions to answer and are looking forward to what we can uncover using these models! thank you 🙂

Hyaluronan‐protein interactions: Lilliput revisited Hyaluronan (HA) is a huge linear polysaccharide composed entirely of a simple repeating disaccharide that has been preserved unchanged since the evolution of vertebrates ~520 million years ago. It is...

Time to read this comprehensive review by Tony Day, part of our IL-13-HA team. onlinelibrary.wiley.com/doi/full/10.... Watch this space for Becky’s paper on Il-13 and Hyaluronan in the lung after nematode migration. @becky-dodd.bsky.social @drtesutherland.bsky.social

Skipping over to blue sky with happy news - the new pre-print from @drtesutherland.bsky.social lab is online now. Immune cells, matrix (🩷) and more. So grateful to be involved - huge effort from the lead authors - especially @james-ep.bsky.social 👏